P63.H12INVITRO.0.PS.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	P63.H12INVITRO.0.PS.A
Gene (human)	TP63 (GeneCards)
Gene synonyms (human)	KET, P63, P73H, P73L, TP73L
Gene (mouse)	Tp63
Gene synonyms (mouse)	P63, P73l, Tp73l, Trp63
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	20
Consensus	dCRWGYhnnRACATGThnnn
GC content	43.73%
Information content (bits; total / per base)	16.839 / 0.842
Data sources	ChIP-Seq + HT-SELEX
Aligned words	1311

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	41 (268)	0.902	0.96	0.824	0.924	0.865	0.951	3.347	4.896	425.918	811.367
Mouse	3 (16)	0.83	0.862	0.717	0.739	0.782	0.819	2.455	3.091	147.27	201.745

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Non-Methyl HT-SELEX, 1 experiments	median	0.68	0.68	0.606	0.604	0.563	0.565
Non-Methyl HT-SELEX, 1 experiments	best	0.68	0.68	0.606	0.604	0.563	0.565

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	5.921	28.756	0.36	0.27

TF superclass	Immunoglobulin fold {6} (TFClass)
TF class	p53 domain factors {6.3} (TFClass)
TF family	p53-related {6.3.1} (TFClass)
TF subfamily	{6.3.1.0} (TFClass)
TFClass ID	TFClass: 6.3.1.0.2
HGNC	HGNC:15979
MGI	MGI:1330810
EntrezGene (human)	GeneID:8626 (SSTAR profile)
EntrezGene (mouse)	GeneID:22061 (SSTAR profile)
UniProt ID (human)	P63_HUMAN
UniProt ID (mouse)	P63_MOUSE
UniProt AC (human)	Q9H3D4 (TFClass)
UniProt AC (mouse)	O88898 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	41 human, 3 mouse
HT-SELEX	1
Methyl-HT-SELEX	0

PCM	P63.H12INVITRO.0.PS.A.pcm
PWM	P63.H12INVITRO.0.PS.A.pwm
PFM	P63.H12INVITRO.0.PS.A.pfm
Alignment	P63.H12INVITRO.0.PS.A.words.tsv
Threshold to P-value map	P63.H12INVITRO.0.PS.A.thr
Motif in other formats
JASPAR format	P63.H12INVITRO.0.PS.A_jaspar_format.txt
MEME format	P63.H12INVITRO.0.PS.A_meme_format.meme
Transfac format	P63.H12INVITRO.0.PS.A_transfac_format.txt
Homer format	P63.H12INVITRO.0.PS.A_homer_format_0.001.txt P63.H12INVITRO.0.PS.A_homer_format_0.0005.txt P63.H12INVITRO.0.PS.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	730.0	98.0	303.0	180.0
02	46.5	1145.5	42.5	76.5
03	878.0	84.0	204.0	145.0
04	324.0	90.0	60.0	837.0
05	67.0	56.0	1129.0	59.0
06	85.0	181.0	51.0	994.0
07	155.0	633.0	76.0	447.0
08	302.0	494.0	288.0	227.0
09	186.0	448.0	384.0	293.0
10	705.0	43.0	424.0	139.0
11	1199.0	8.0	87.0	17.0
12	1.0	1306.0	1.0	3.0
13	1285.0	4.0	4.0	18.0
14	4.0	4.0	1.0	1302.0
15	4.0	2.0	1298.0	7.0
16	37.0	144.0	11.0	1119.0
17	210.0	476.0	48.0	577.0
18	439.0	238.0	304.0	330.0
19	556.75	215.75	322.75	215.75
20	304.25	246.25	511.25	249.25

PFM

	A	C	G	T
01	0.557	0.075	0.231	0.137
02	0.035	0.874	0.032	0.058
03	0.67	0.064	0.156	0.111
04	0.247	0.069	0.046	0.638
05	0.051	0.043	0.861	0.045
06	0.065	0.138	0.039	0.758
07	0.118	0.483	0.058	0.341
08	0.23	0.377	0.22	0.173
09	0.142	0.342	0.293	0.223
10	0.538	0.033	0.323	0.106
11	0.915	0.006	0.066	0.013
12	0.001	0.996	0.001	0.002
13	0.98	0.003	0.003	0.014
14	0.003	0.003	0.001	0.993
15	0.003	0.002	0.99	0.005
16	0.028	0.11	0.008	0.854
17	0.16	0.363	0.037	0.44
18	0.335	0.182	0.232	0.252
19	0.425	0.165	0.246	0.165
20	0.232	0.188	0.39	0.19

PWM

	A	C	G	T
01	0.798	-1.195	-0.078	-0.595
02	-1.92	1.247	-2.007	-1.437
03	0.982	-1.346	-0.471	-0.809
04	-0.011	-1.278	-1.674	0.934
05	-1.567	-1.741	1.233	-1.69
06	-1.334	-0.589	-1.831	1.106
07	-0.743	0.656	-1.444	0.309
08	-0.081	0.408	-0.129	-0.365
09	-0.562	0.311	0.158	-0.111
10	0.763	-1.996	0.256	-0.85
11	1.293	-3.516	-1.311	-2.864
12	-4.77	1.378	-4.77	-4.23
13	1.362	-4.041	-4.041	-2.812
14	-4.041	-4.041	-4.77	1.375
15	-4.041	-4.464	1.372	-3.624
16	-2.139	-0.816	-3.249	1.224
17	-0.442	0.371	-1.89	0.563
18	0.291	-0.318	-0.075	0.007
19	0.528	-0.415	-0.015	-0.415
20	-0.074	-0.284	0.443	-0.272

Standard thresholds

P-value	Threshold
0.001	1.92661
0.0005	3.24261
0.0001	5.98756