P63.H12CORE.1.PS.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	P63.H12CORE.1.PS.A
Gene (human)	TP63 (GeneCards)
Gene synonyms (human)	KET, P63, P73H, P73L, TP73L
Gene (mouse)	Tp63
Gene synonyms (mouse)	P63, P73l, Tp73l, Trp63
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	A

Motif length	12
Consensus	hbRRRCWTGYhb
GC content	51.26%
Information content (bits; total / per base)	10.481 / 0.873
Data sources	ChIP-Seq + HT-SELEX
Aligned words	1000

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	41 (268)	0.863	0.903	0.728	0.838	0.763	0.821	2.172	2.777	267.436	495.509
Mouse	3 (16)	0.798	0.828	0.643	0.659	0.705	0.738	1.86	1.982	115.732	148.056

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Non-Methyl HT-SELEX, 1 experiments	median	0.647	0.625	0.582	0.574	0.545	0.546
Non-Methyl HT-SELEX, 1 experiments	best	0.647	0.625	0.582	0.574	0.545	0.546

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	5.668	28.667	0.323	0.248

TF superclass	Immunoglobulin fold {6} (TFClass)
TF class	p53 domain factors {6.3} (TFClass)
TF family	p53-related {6.3.1} (TFClass)
TF subfamily	{6.3.1.0} (TFClass)
TFClass ID	TFClass: 6.3.1.0.2
HGNC	HGNC:15979
MGI	MGI:1330810
EntrezGene (human)	GeneID:8626 (SSTAR profile)
EntrezGene (mouse)	GeneID:22061 (SSTAR profile)
UniProt ID (human)	P63_HUMAN
UniProt ID (mouse)	P63_MOUSE
UniProt AC (human)	Q9H3D4 (TFClass)
UniProt AC (mouse)	O88898 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	41 human, 3 mouse
HT-SELEX	1
Methyl-HT-SELEX	0

PCM	P63.H12CORE.1.PS.A.pcm
PWM	P63.H12CORE.1.PS.A.pwm
PFM	P63.H12CORE.1.PS.A.pfm
Alignment	P63.H12CORE.1.PS.A.words.tsv
Threshold to P-value map	P63.H12CORE.1.PS.A.thr
Motif in other formats
JASPAR format	P63.H12CORE.1.PS.A_jaspar_format.txt
MEME format	P63.H12CORE.1.PS.A_meme_format.meme
Transfac format	P63.H12CORE.1.PS.A_transfac_format.txt
Homer format	P63.H12CORE.1.PS.A_homer_format_0.001.txt P63.H12CORE.1.PS.A_homer_format_0.0005.txt P63.H12CORE.1.PS.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	158.0	469.0	88.0	285.0
02	65.0	528.0	177.0	230.0
03	542.0	30.0	221.0	207.0
04	198.0	23.0	743.0	36.0
05	517.0	2.0	440.0	41.0
06	0.0	999.0	1.0	0.0
07	544.0	59.0	5.0	392.0
08	7.0	20.0	9.0	964.0
09	0.0	0.0	1000.0	0.0
10	27.0	378.0	2.0	593.0
11	154.0	241.0	65.0	540.0
12	102.0	416.0	235.0	247.0

PFM

	A	C	G	T
01	0.158	0.469	0.088	0.285
02	0.065	0.528	0.177	0.23
03	0.542	0.03	0.221	0.207
04	0.198	0.023	0.743	0.036
05	0.517	0.002	0.44	0.041
06	0.0	0.999	0.001	0.0
07	0.544	0.059	0.005	0.392
08	0.007	0.02	0.009	0.964
09	0.0	0.0	1.0	0.0
10	0.027	0.378	0.002	0.593
11	0.154	0.241	0.065	0.54
12	0.102	0.416	0.235	0.247

PWM

	A	C	G	T
01	-0.455	0.626	-1.032	0.13
02	-1.328	0.744	-0.342	-0.083
03	0.77	-2.071	-0.122	-0.187
04	-0.231	-2.32	1.085	-1.898
05	0.723	-4.213	0.562	-1.774
06	-4.982	1.38	-4.525	-4.982
07	0.774	-1.422	-3.622	0.447
08	-3.362	-2.45	-3.156	1.345
09	-4.982	-4.982	1.381	-4.982
10	-2.171	0.411	-4.213	0.86
11	-0.48	-0.036	-1.328	0.766
12	-0.887	0.506	-0.061	-0.012

Standard thresholds

P-value	Threshold
0.001	4.70986
0.0005	5.728165
0.0001	7.536985