P63.H12CORE.0.PS.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	P63.H12CORE.0.PS.A
Gene (human)	TP63 (GeneCards)
Gene synonyms (human)	KET, P63, P73H, P73L, TP73L
Gene (mouse)	Tp63
Gene synonyms (mouse)	P63, P73l, Tp73l, Trp63
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	19
Consensus	vdRCRWGYhShRRCWYGYh
GC content	54.05%
Information content (bits; total / per base)	14.638 / 0.77
Data sources	ChIP-Seq + HT-SELEX
Aligned words	1003

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	41 (268)	0.983	0.996	0.966	0.992	0.97	0.991	5.139	6.226	600.79	969.699
Mouse	3 (16)	0.932	0.97	0.898	0.938	0.916	0.955	4.232	4.53	356.543	433.456

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Non-Methyl HT-SELEX, 1 experiments	median	0.636	0.65	0.562	0.576	0.531	0.544
Non-Methyl HT-SELEX, 1 experiments	best	0.636	0.65	0.562	0.576	0.531	0.544

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	10.072	42.326	0.425	0.294

TF superclass	Immunoglobulin fold {6} (TFClass)
TF class	p53 domain factors {6.3} (TFClass)
TF family	p53-related {6.3.1} (TFClass)
TF subfamily	{6.3.1.0} (TFClass)
TFClass ID	TFClass: 6.3.1.0.2
HGNC	HGNC:15979
MGI	MGI:1330810
EntrezGene (human)	GeneID:8626 (SSTAR profile)
EntrezGene (mouse)	GeneID:22061 (SSTAR profile)
UniProt ID (human)	P63_HUMAN
UniProt ID (mouse)	P63_MOUSE
UniProt AC (human)	Q9H3D4 (TFClass)
UniProt AC (mouse)	O88898 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	41 human, 3 mouse
HT-SELEX	1
Methyl-HT-SELEX	0

PCM	P63.H12CORE.0.PS.A.pcm
PWM	P63.H12CORE.0.PS.A.pwm
PFM	P63.H12CORE.0.PS.A.pfm
Alignment	P63.H12CORE.0.PS.A.words.tsv
Threshold to P-value map	P63.H12CORE.0.PS.A.thr
Motif in other formats
JASPAR format	P63.H12CORE.0.PS.A_jaspar_format.txt
MEME format	P63.H12CORE.0.PS.A_meme_format.meme
Transfac format	P63.H12CORE.0.PS.A_transfac_format.txt
Homer format	P63.H12CORE.0.PS.A_homer_format_0.001.txt P63.H12CORE.0.PS.A_homer_format_0.0005.txt P63.H12CORE.0.PS.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	302.0	174.0	374.0	153.0
02	303.0	84.0	407.0	209.0
03	441.0	21.0	448.0	93.0
04	5.0	978.0	5.0	15.0
05	725.0	96.0	106.0	76.0
06	351.0	12.0	132.0	508.0
07	1.0	0.0	1002.0	0.0
08	108.0	384.0	3.0	508.0
09	139.0	429.0	130.0	305.0
10	16.0	734.0	186.0	67.0
11	510.0	201.0	43.0	249.0
12	236.0	56.0	593.0	118.0
13	466.0	5.0	405.0	127.0
14	0.0	1002.0	0.0	1.0
15	554.0	141.0	15.0	293.0
16	84.0	102.0	85.0	732.0
17	12.0	3.0	986.0	2.0
18	72.0	479.0	16.0	436.0
19	217.0	365.0	98.0	323.0

PFM

	A	C	G	T
01	0.301	0.173	0.373	0.153
02	0.302	0.084	0.406	0.208
03	0.44	0.021	0.447	0.093
04	0.005	0.975	0.005	0.015
05	0.723	0.096	0.106	0.076
06	0.35	0.012	0.132	0.506
07	0.001	0.0	0.999	0.0
08	0.108	0.383	0.003	0.506
09	0.139	0.428	0.13	0.304
10	0.016	0.732	0.185	0.067
11	0.508	0.2	0.043	0.248
12	0.235	0.056	0.591	0.118
13	0.465	0.005	0.404	0.127
14	0.0	0.999	0.0	0.001
15	0.552	0.141	0.015	0.292
16	0.084	0.102	0.085	0.73
17	0.012	0.003	0.983	0.002
18	0.072	0.478	0.016	0.435
19	0.216	0.364	0.098	0.322

PWM

	A	C	G	T
01	0.185	-0.362	0.398	-0.49
02	0.188	-1.08	0.482	-0.181
03	0.562	-2.408	0.577	-0.98
04	-3.625	1.356	-3.625	-2.714
05	1.057	-0.949	-0.852	-1.178
06	0.334	-2.912	-0.636	0.703
07	-4.528	-4.985	1.38	-4.985
08	-0.833	0.424	-3.978	0.703
09	-0.584	0.534	-0.651	0.195
10	-2.656	1.07	-0.296	-1.301
11	0.706	-0.219	-1.731	-0.007
12	-0.06	-1.476	0.857	-0.746
13	0.617	-3.625	0.477	-0.674
14	-4.985	1.38	-4.985	-4.528
15	0.789	-0.57	-2.714	0.155
16	-1.08	-0.89	-1.069	1.067
17	-2.912	-3.978	1.364	-4.216
18	-1.231	0.644	-2.656	0.55
19	-0.143	0.373	-0.929	0.252

Standard thresholds

P-value	Threshold
0.001	2.90566
0.0005	4.16396
0.0001	6.74046