P53.H12RSNP.0.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	P53.H12RSNP.0.P.B
Gene (human)	TP53 (GeneCards)
Gene synonyms (human)	P53
Gene (mouse)	Tp53
Gene synonyms (mouse)	P53, Trp53
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	19
Consensus	ddYWKGYCYRGRCWTGYYY
GC content	56.11%
Information content (bits; total / per base)	16.592 / 0.873
Data sources	ChIP-Seq
Aligned words	926

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	97 (581)	0.919	0.998	0.914	0.995	0.906	0.998	6.641	9.363	314.854	941.585
Mouse	15 (101)	0.972	0.997	0.955	0.99	0.962	0.997	7.482	10.928	444.658	887.62

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Non-Methyl HT-SELEX, 1 experiments	median	0.642	0.622	0.584	0.574	0.55	0.547
Non-Methyl HT-SELEX, 1 experiments	best	0.642	0.622	0.584	0.574	0.55	0.547

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	4.667	1.897	0.015	0.003

TF superclass	Immunoglobulin fold {6} (TFClass)
TF class	p53 domain factors {6.3} (TFClass)
TF family	p53-related {6.3.1} (TFClass)
TF subfamily	{6.3.1.0} (TFClass)
TFClass ID	TFClass: 6.3.1.0.1
HGNC	HGNC:11998
MGI	MGI:98834
EntrezGene (human)	GeneID:7157 (SSTAR profile)
EntrezGene (mouse)	GeneID:22059 (SSTAR profile)
UniProt ID (human)	P53_HUMAN
UniProt ID (mouse)	P53_MOUSE
UniProt AC (human)	P04637 (TFClass)
UniProt AC (mouse)	P02340 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	97 human, 15 mouse
HT-SELEX	1
Methyl-HT-SELEX	0

PCM	P53.H12RSNP.0.P.B.pcm
PWM	P53.H12RSNP.0.P.B.pwm
PFM	P53.H12RSNP.0.P.B.pfm
Alignment	P53.H12RSNP.0.P.B.words.tsv
Threshold to P-value map	P53.H12RSNP.0.P.B.thr
Motif in other formats
JASPAR format	P53.H12RSNP.0.P.B_jaspar_format.txt
MEME format	P53.H12RSNP.0.P.B_meme_format.meme
Transfac format	P53.H12RSNP.0.P.B_transfac_format.txt
Homer format	P53.H12RSNP.0.P.B_homer_format_0.001.txt P53.H12RSNP.0.P.B_homer_format_0.0005.txt P53.H12RSNP.0.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	220.0	73.0	499.0	134.0
02	433.0	116.0	251.0	126.0
03	65.0	722.0	32.0	107.0
04	418.0	78.0	46.0	384.0
05	82.0	20.0	96.0	728.0
06	16.0	47.0	811.0	52.0
07	27.0	596.0	9.0	294.0
08	37.0	764.0	18.0	107.0
09	68.0	250.0	43.0	565.0
10	151.0	32.0	630.0	113.0
11	92.0	25.0	743.0	66.0
12	410.0	7.0	462.0	47.0
13	8.0	906.0	6.0	6.0
14	520.0	16.0	5.0	385.0
15	85.0	7.0	52.0	782.0
16	14.0	13.0	885.0	14.0
17	31.0	425.0	13.0	457.0
18	60.0	650.0	33.0	183.0
19	66.0	456.0	35.0	369.0

PFM

	A	C	G	T
01	0.238	0.079	0.539	0.145
02	0.468	0.125	0.271	0.136
03	0.07	0.78	0.035	0.116
04	0.451	0.084	0.05	0.415
05	0.089	0.022	0.104	0.786
06	0.017	0.051	0.876	0.056
07	0.029	0.644	0.01	0.317
08	0.04	0.825	0.019	0.116
09	0.073	0.27	0.046	0.61
10	0.163	0.035	0.68	0.122
11	0.099	0.027	0.802	0.071
12	0.443	0.008	0.499	0.051
13	0.009	0.978	0.006	0.006
14	0.562	0.017	0.005	0.416
15	0.092	0.008	0.056	0.844
16	0.015	0.014	0.956	0.015
17	0.033	0.459	0.014	0.494
18	0.065	0.702	0.036	0.198
19	0.071	0.492	0.038	0.398

PWM

	A	C	G	T
01	-0.051	-1.138	0.764	-0.541
02	0.623	-0.684	0.08	-0.602
03	-1.252	1.132	-1.934	-0.763
04	0.588	-1.074	-1.587	0.503
05	-1.025	-2.374	-0.87	1.141
06	-2.578	-1.566	1.248	-1.468
07	-2.095	0.941	-3.081	0.237
08	-1.796	1.189	-2.471	-0.763
09	-1.208	0.076	-1.652	0.888
10	-0.423	-1.934	0.996	-0.71
11	-0.912	-2.167	1.161	-1.237
12	0.568	-3.288	0.687	-1.566
13	-3.179	1.359	-3.41	-3.41
14	0.805	-2.578	-3.549	0.506
15	-0.989	-3.288	-1.468	1.212
16	-2.698	-2.764	1.336	-2.698
17	-1.964	0.604	-2.764	0.676
18	-1.33	1.028	-1.905	-0.233
19	-1.237	0.674	-1.849	0.463

Standard thresholds

P-value	Threshold
0.001	2.61886
0.0005	3.77526
0.0001	6.21491