P53.H12INVIVO.0.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	P53.H12INVIVO.0.P.B
Gene (human)	TP53 (GeneCards)
Gene synonyms (human)	P53
Gene (mouse)	Tp53
Gene synonyms (mouse)	P53, Trp53
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	21
Consensus	bdRdCWTGYCYdRRCATGYYY
GC content	53.78%
Information content (bits; total / per base)	18.73 / 0.892
Data sources	ChIP-Seq
Aligned words	1022

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	97 (581)	0.922	0.998	0.918	0.997	0.91	0.998	7.372	10.238	330.409	964.409
Mouse	15 (101)	0.966	0.997	0.951	0.995	0.958	0.996	7.415	10.969	443.824	878.678

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Non-Methyl HT-SELEX, 1 experiments	median	0.653	0.632	0.594	0.581	0.557	0.553
Non-Methyl HT-SELEX, 1 experiments	best	0.653	0.632	0.594	0.581	0.557	0.553

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	4.65	1.897	0.012	-0.001

TF superclass	Immunoglobulin fold {6} (TFClass)
TF class	p53 domain factors {6.3} (TFClass)
TF family	p53-related {6.3.1} (TFClass)
TF subfamily	{6.3.1.0} (TFClass)
TFClass ID	TFClass: 6.3.1.0.1
HGNC	HGNC:11998
MGI	MGI:98834
EntrezGene (human)	GeneID:7157 (SSTAR profile)
EntrezGene (mouse)	GeneID:22059 (SSTAR profile)
UniProt ID (human)	P53_HUMAN
UniProt ID (mouse)	P53_MOUSE
UniProt AC (human)	P04637 (TFClass)
UniProt AC (mouse)	P02340 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	97 human, 15 mouse
HT-SELEX	1
Methyl-HT-SELEX	0

PCM	P53.H12INVIVO.0.P.B.pcm
PWM	P53.H12INVIVO.0.P.B.pwm
PFM	P53.H12INVIVO.0.P.B.pfm
Alignment	P53.H12INVIVO.0.P.B.words.tsv
Threshold to P-value map	P53.H12INVIVO.0.P.B.thr
Motif in other formats
JASPAR format	P53.H12INVIVO.0.P.B_jaspar_format.txt
MEME format	P53.H12INVIVO.0.P.B_meme_format.meme
Transfac format	P53.H12INVIVO.0.P.B_transfac_format.txt
Homer format	P53.H12INVIVO.0.P.B_homer_format_0.001.txt P53.H12INVIVO.0.P.B_homer_format_0.0005.txt P53.H12INVIVO.0.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	163.0	190.0	461.0	208.0
02	335.0	71.0	406.0	210.0
03	184.0	52.0	630.0	156.0
04	551.0	83.0	279.0	109.0
05	20.0	807.0	32.0	163.0
06	519.0	67.0	50.0	386.0
07	152.0	18.0	28.0	824.0
08	10.0	5.0	990.0	17.0
09	18.0	584.0	3.0	417.0
10	34.0	860.0	27.0	101.0
11	66.0	486.0	10.0	460.0
12	376.0	109.0	401.0	136.0
13	193.0	31.0	670.0	128.0
14	548.0	2.0	428.0	44.0
15	0.0	1020.0	1.0	1.0
16	859.0	14.0	12.0	137.0
17	22.0	8.0	7.0	985.0
18	7.0	6.0	1009.0	0.0
19	21.0	411.0	4.0	586.0
20	46.0	617.0	37.0	322.0
21	86.0	560.0	56.0	320.0

PFM

	A	C	G	T
01	0.159	0.186	0.451	0.204
02	0.328	0.069	0.397	0.205
03	0.18	0.051	0.616	0.153
04	0.539	0.081	0.273	0.107
05	0.02	0.79	0.031	0.159
06	0.508	0.066	0.049	0.378
07	0.149	0.018	0.027	0.806
08	0.01	0.005	0.969	0.017
09	0.018	0.571	0.003	0.408
10	0.033	0.841	0.026	0.099
11	0.065	0.476	0.01	0.45
12	0.368	0.107	0.392	0.133
13	0.189	0.03	0.656	0.125
14	0.536	0.002	0.419	0.043
15	0.0	0.998	0.001	0.001
16	0.841	0.014	0.012	0.134
17	0.022	0.008	0.007	0.964
18	0.007	0.006	0.987	0.0
19	0.021	0.402	0.004	0.573
20	0.045	0.604	0.036	0.315
21	0.084	0.548	0.055	0.313

PWM

	A	C	G	T
01	-0.446	-0.294	0.587	-0.204
02	0.269	-1.263	0.461	-0.195
03	-0.326	-1.566	0.898	-0.489
04	0.765	-1.11	0.087	-0.843
05	-2.471	1.145	-2.032	-0.446
06	0.705	-1.32	-1.604	0.41
07	-0.515	-2.568	-2.158	1.166
08	-3.088	-3.643	1.349	-2.62
09	-2.568	0.823	-3.996	0.487
10	-1.974	1.209	-2.192	-0.918
11	-1.334	0.64	-3.088	0.585
12	0.384	-0.843	0.448	-0.625
13	-0.278	-2.062	0.96	-0.685
14	0.759	-4.233	0.513	-1.727
15	-5.0	1.379	-4.545	-4.545
16	1.208	-2.794	-2.93	-0.617
17	-2.383	-3.275	-3.383	1.344
18	-3.383	-3.505	1.368	-5.0
19	-2.426	0.473	-3.804	0.826
20	-1.684	0.878	-1.893	0.23
21	-1.076	0.781	-1.494	0.224

Standard thresholds

P-value	Threshold
0.001	1.01961
0.0005	2.40611
0.0001	5.31691