P53.H12INVITRO.0.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	P53.H12INVITRO.0.P.B
Gene (human)	TP53 (GeneCards)
Gene synonyms (human)	P53
Gene (mouse)	Tp53
Gene synonyms (mouse)	P53, Trp53
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	20
Consensus	dYWWGYhhvRRCWTGYYYdv
GC content	51.86%
Information content (bits; total / per base)	13.24 / 0.662
Data sources	ChIP-Seq
Aligned words	907

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	97 (581)	0.918	0.998	0.915	0.996	0.907	0.998	6.979	9.804	300.921	986.745
Mouse	15 (101)	0.962	0.997	0.94	0.995	0.955	0.996	6.927	10.087	442.469	869.796

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Non-Methyl HT-SELEX, 1 experiments	median	0.681	0.653	0.617	0.598	0.573	0.565
Non-Methyl HT-SELEX, 1 experiments	best	0.681	0.653	0.617	0.598	0.573	0.565

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	2.393	0.844	0.008	-0.001

TF superclass	Immunoglobulin fold {6} (TFClass)
TF class	p53 domain factors {6.3} (TFClass)
TF family	p53-related {6.3.1} (TFClass)
TF subfamily	{6.3.1.0} (TFClass)
TFClass ID	TFClass: 6.3.1.0.1
HGNC	HGNC:11998
MGI	MGI:98834
EntrezGene (human)	GeneID:7157 (SSTAR profile)
EntrezGene (mouse)	GeneID:22059 (SSTAR profile)
UniProt ID (human)	P53_HUMAN
UniProt ID (mouse)	P53_MOUSE
UniProt AC (human)	P04637 (TFClass)
UniProt AC (mouse)	P02340 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	97 human, 15 mouse
HT-SELEX	1
Methyl-HT-SELEX	0

PCM	P53.H12INVITRO.0.P.B.pcm
PWM	P53.H12INVITRO.0.P.B.pwm
PFM	P53.H12INVITRO.0.P.B.pfm
Alignment	P53.H12INVITRO.0.P.B.words.tsv
Threshold to P-value map	P53.H12INVITRO.0.P.B.thr
Motif in other formats
JASPAR format	P53.H12INVITRO.0.P.B_jaspar_format.txt
MEME format	P53.H12INVITRO.0.P.B_meme_format.meme
Transfac format	P53.H12INVITRO.0.P.B_transfac_format.txt
Homer format	P53.H12INVITRO.0.P.B_homer_format_0.001.txt P53.H12INVITRO.0.P.B_homer_format_0.0005.txt P53.H12INVITRO.0.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	389.0	75.0	295.0	148.0
02	41.0	706.0	58.0	102.0
03	545.0	108.0	67.0	187.0
04	166.0	50.0	77.0	614.0
05	59.0	58.0	748.0	42.0
06	73.0	418.0	44.0	372.0
07	157.0	499.0	78.0	173.0
08	115.0	423.0	101.0	268.0
09	369.0	136.0	276.0	126.0
10	247.0	65.0	504.0	91.0
11	557.0	18.0	277.0	55.0
12	11.0	877.0	14.0	5.0
13	704.0	41.0	15.0	147.0
14	59.0	26.0	28.0	794.0
15	22.0	12.0	854.0	19.0
16	24.0	413.0	18.0	452.0
17	92.0	613.0	12.0	190.0
18	96.0	417.0	38.0	356.0
19	319.0	96.0	247.0	245.0
20	152.0	213.0	392.0	150.0

PFM

	A	C	G	T
01	0.429	0.083	0.325	0.163
02	0.045	0.778	0.064	0.112
03	0.601	0.119	0.074	0.206
04	0.183	0.055	0.085	0.677
05	0.065	0.064	0.825	0.046
06	0.08	0.461	0.049	0.41
07	0.173	0.55	0.086	0.191
08	0.127	0.466	0.111	0.295
09	0.407	0.15	0.304	0.139
10	0.272	0.072	0.556	0.1
11	0.614	0.02	0.305	0.061
12	0.012	0.967	0.015	0.006
13	0.776	0.045	0.017	0.162
14	0.065	0.029	0.031	0.875
15	0.024	0.013	0.942	0.021
16	0.026	0.455	0.02	0.498
17	0.101	0.676	0.013	0.209
18	0.106	0.46	0.042	0.393
19	0.352	0.106	0.272	0.27
20	0.168	0.235	0.432	0.165

PWM

	A	C	G	T
01	0.537	-1.091	0.261	-0.423
02	-1.677	1.131	-1.342	-0.79
03	0.873	-0.734	-1.202	-0.191
04	-0.309	-1.486	-1.066	0.991
05	-1.325	-1.342	1.188	-1.654
06	-1.118	0.608	-1.609	0.492
07	-0.364	0.785	-1.053	-0.268
08	-0.672	0.62	-0.799	0.166
09	0.484	-0.506	0.195	-0.582
10	0.085	-1.231	0.795	-0.902
11	0.894	-2.451	0.199	-1.394
12	-2.89	1.347	-2.678	-3.529
13	1.128	-1.677	-2.616	-0.429
14	-1.325	-2.11	-2.04	1.248
15	-2.266	-2.814	1.321	-2.401
16	-2.185	0.596	-2.451	0.686
17	-0.891	0.99	-2.814	-0.175
18	-0.849	0.606	-1.75	0.448
19	0.339	-0.849	0.085	0.077
20	-0.396	-0.062	0.544	-0.409

Standard thresholds

P-value	Threshold
0.001	3.90411
0.0005	4.87671
0.0001	6.91916