OTX1.H12INVIVO.1.S.D motif - HOmo sapiens COmprehensive MOdel COllection

Motif	OTX1.H12INVIVO.1.S.D
Gene (human)	OTX1 (GeneCards)
Gene synonyms (human)
Gene (mouse)	Otx1
Gene synonyms (mouse)	Otx-1
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	D

Motif length	14
Consensus	WWAKCGGATTAdnn
GC content	37.88%
Information content (bits; total / per base)	15.757 / 1.126
Data sources	HT-SELEX
Aligned words	1661

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 10 experiments	median	0.931	0.887	0.912	0.864	0.846	0.811
Overall, 10 experiments	best	0.992	0.989	0.975	0.962	0.951	0.932
Methyl HT-SELEX, 3 experiments	median	0.925	0.877	0.907	0.855	0.86	0.812
Methyl HT-SELEX, 3 experiments	best	0.985	0.977	0.972	0.958	0.934	0.916
Non-Methyl HT-SELEX, 7 experiments	median	0.936	0.897	0.917	0.872	0.832	0.81
Non-Methyl HT-SELEX, 7 experiments	best	0.992	0.989	0.975	0.962	0.951	0.932

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.982	0.808	0.957	0.525
batch 2	0.822	0.652	0.866	0.655

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	Paired-related HD {3.1.3} (TFClass)
TF subfamily	OTX {3.1.3.17} (TFClass)
TFClass ID	TFClass: 3.1.3.17.1
HGNC	HGNC:8521
MGI	MGI:97450
EntrezGene (human)	GeneID:5013 (SSTAR profile)
EntrezGene (mouse)	GeneID:18423 (SSTAR profile)
UniProt ID (human)	OTX1_HUMAN
UniProt ID (mouse)	OTX1_MOUSE
UniProt AC (human)	P32242 (TFClass)
UniProt AC (mouse)	P80205 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 0 mouse
HT-SELEX	7
Methyl-HT-SELEX	3

PCM	OTX1.H12INVIVO.1.S.D.pcm
PWM	OTX1.H12INVIVO.1.S.D.pwm
PFM	OTX1.H12INVIVO.1.S.D.pfm
Alignment	OTX1.H12INVIVO.1.S.D.words.tsv
Threshold to P-value map	OTX1.H12INVIVO.1.S.D.thr
Motif in other formats
JASPAR format	OTX1.H12INVIVO.1.S.D_jaspar_format.txt
MEME format	OTX1.H12INVIVO.1.S.D_meme_format.meme
Transfac format	OTX1.H12INVIVO.1.S.D_transfac_format.txt
Homer format	OTX1.H12INVIVO.1.S.D_homer_format_0.001.txt OTX1.H12INVIVO.1.S.D_homer_format_0.0005.txt OTX1.H12INVIVO.1.S.D_homer_format_0.0001.txt

PCM

	A	C	G	T
01	321.25	159.25	131.25	1049.25
02	1232.5	151.5	114.5	162.5
03	1368.0	67.0	93.0	133.0
04	68.0	176.0	631.0	786.0
05	48.0	1548.0	36.0	29.0
06	16.0	258.0	1379.0	8.0
07	0.0	0.0	1661.0	0.0
08	1607.0	54.0	0.0	0.0
09	0.0	0.0	0.0	1661.0
10	0.0	0.0	0.0	1661.0
11	1660.0	0.0	0.0	1.0
12	920.0	175.0	348.0	218.0
13	230.5	357.5	568.5	504.5
14	353.5	458.5	440.5	408.5

PFM

	A	C	G	T
01	0.193	0.096	0.079	0.632
02	0.742	0.091	0.069	0.098
03	0.824	0.04	0.056	0.08
04	0.041	0.106	0.38	0.473
05	0.029	0.932	0.022	0.017
06	0.01	0.155	0.83	0.005
07	0.0	0.0	1.0	0.0
08	0.967	0.033	0.0	0.0
09	0.0	0.0	0.0	1.0
10	0.0	0.0	0.0	1.0
11	0.999	0.0	0.0	0.001
12	0.554	0.105	0.21	0.131
13	0.139	0.215	0.342	0.304
14	0.213	0.276	0.265	0.246

PWM

	A	C	G	T
01	-0.255	-0.951	-1.142	0.924
02	1.085	-1.001	-1.277	-0.931
03	1.189	-1.801	-1.481	-1.129
04	-1.787	-0.852	0.417	0.636
05	-2.124	1.313	-2.4	-2.604
06	-3.151	-0.473	1.197	-3.745
07	-5.416	-5.416	1.383	-5.416
08	1.35	-2.011	-5.416	-5.416
09	-5.416	-5.416	-5.416	1.383
10	-5.416	-5.416	-5.416	1.383
11	1.382	-5.416	-5.416	-4.985
12	0.793	-0.858	-0.176	-0.64
13	-0.585	-0.149	0.313	0.194
14	-0.16	0.099	0.059	-0.016

Standard thresholds

P-value	Threshold
0.001	1.54041
0.0005	3.05361
0.0001	6.18371