ONEC2.H12RSNP.3.P.D motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ONEC2.H12RSNP.3.P.D
Gene (human)	ONECUT2 (GeneCards)
Gene synonyms (human)	HNF6B
Gene (mouse)	Onecut2
Gene synonyms (mouse)	Oc2
LOGO
LOGO (reverse complement)
Motif subtype	3
Quality	D

Motif length	22
Consensus	ATKKWTTKATTGATTKWTTKWT
GC content	22.34%
Information content (bits; total / per base)	28.307 / 1.287
Data sources	ChIP-Seq
Aligned words	257

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	4 (22)	0.762	0.89	0.676	0.846	0.684	0.769	2.388	2.9	20.194	62.921
Mouse	2 (12)	0.962	0.978	0.934	0.959	0.742	0.793	5.064	6.505	245.37	325.959

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 8 experiments	median	0.967	0.95	0.885	0.867	0.783	0.765
Overall, 8 experiments	best	0.994	0.991	0.99	0.984	0.981	0.972
Methyl HT-SELEX, 3 experiments	median	0.993	0.988	0.99	0.983	0.967	0.958
Methyl HT-SELEX, 3 experiments	best	0.994	0.991	0.99	0.984	0.981	0.972
Non-Methyl HT-SELEX, 5 experiments	median	0.905	0.858	0.839	0.794	0.729	0.711
Non-Methyl HT-SELEX, 5 experiments	best	0.983	0.969	0.977	0.96	0.963	0.943

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	HD-CUT {3.1.9} (TFClass)
TF subfamily	ONECUT {3.1.9.1} (TFClass)
TFClass ID	TFClass: 3.1.9.1.2
HGNC	HGNC:8139
MGI	MGI:1891408
EntrezGene (human)	GeneID:9480 (SSTAR profile)
EntrezGene (mouse)	GeneID:225631 (SSTAR profile)
UniProt ID (human)	ONEC2_HUMAN
UniProt ID (mouse)	ONEC2_MOUSE
UniProt AC (human)	O95948 (TFClass)
UniProt AC (mouse)	Q6XBJ3 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	4 human, 2 mouse
HT-SELEX	5
Methyl-HT-SELEX	3

PCM	ONEC2.H12RSNP.3.P.D.pcm
PWM	ONEC2.H12RSNP.3.P.D.pwm
PFM	ONEC2.H12RSNP.3.P.D.pfm
Alignment	ONEC2.H12RSNP.3.P.D.words.tsv
Threshold to P-value map	ONEC2.H12RSNP.3.P.D.thr
Motif in other formats
JASPAR format	ONEC2.H12RSNP.3.P.D_jaspar_format.txt
MEME format	ONEC2.H12RSNP.3.P.D_meme_format.meme
Transfac format	ONEC2.H12RSNP.3.P.D_transfac_format.txt
Homer format	ONEC2.H12RSNP.3.P.D_homer_format_0.001.txt ONEC2.H12RSNP.3.P.D_homer_format_0.0005.txt ONEC2.H12RSNP.3.P.D_homer_format_0.0001.txt

PCM

	A	C	G	T
01	203.0	7.0	7.0	40.0
02	22.0	11.0	9.0	215.0
03	19.0	12.0	20.0	206.0
04	21.0	14.0	191.0	31.0
05	191.0	24.0	10.0	32.0
06	13.0	15.0	7.0	222.0
07	7.0	8.0	13.0	229.0
08	4.0	10.0	127.0	116.0
09	257.0	0.0	0.0	0.0
10	0.0	0.0	0.0	257.0
11	0.0	1.0	0.0	256.0
12	0.0	0.0	257.0	0.0
13	257.0	0.0	0.0	0.0
14	0.0	0.0	0.0	257.0
15	0.0	4.0	0.0	253.0
16	11.0	7.0	154.0	85.0
17	179.0	13.0	20.0	45.0
18	6.0	20.0	4.0	227.0
19	6.0	7.0	13.0	231.0
20	12.0	16.0	185.0	44.0
21	176.0	23.0	17.0	41.0
22	13.0	22.0	15.0	207.0

PFM

	A	C	G	T
01	0.79	0.027	0.027	0.156
02	0.086	0.043	0.035	0.837
03	0.074	0.047	0.078	0.802
04	0.082	0.054	0.743	0.121
05	0.743	0.093	0.039	0.125
06	0.051	0.058	0.027	0.864
07	0.027	0.031	0.051	0.891
08	0.016	0.039	0.494	0.451
09	1.0	0.0	0.0	0.0
10	0.0	0.0	0.0	1.0
11	0.0	0.004	0.0	0.996
12	0.0	0.0	1.0	0.0
13	1.0	0.0	0.0	0.0
14	0.0	0.0	0.0	1.0
15	0.0	0.016	0.0	0.984
16	0.043	0.027	0.599	0.331
17	0.696	0.051	0.078	0.175
18	0.023	0.078	0.016	0.883
19	0.023	0.027	0.051	0.899
20	0.047	0.062	0.72	0.171
21	0.685	0.089	0.066	0.16
22	0.051	0.086	0.058	0.805

PWM

	A	C	G	T
01	1.136	-2.057	-2.057	-0.461
02	-1.032	-1.667	-1.844	1.193
03	-1.169	-1.59	-1.121	1.15
04	-1.076	-1.451	1.075	-0.706
05	1.075	-0.95	-1.752	-0.676
06	-1.518	-1.388	-2.057	1.225
07	-2.057	-1.945	-1.518	1.256
08	-2.5	-1.752	0.671	0.581
09	1.37	-3.857	-3.857	-3.857
10	-3.857	-3.857	-3.857	1.37
11	-3.857	-3.314	-3.857	1.366
12	-3.857	-3.857	1.37	-3.857
13	1.37	-3.857	-3.857	-3.857
14	-3.857	-3.857	-3.857	1.37
15	-3.857	-2.5	-3.857	1.355
16	-1.667	-2.057	0.862	0.275
17	1.011	-1.518	-1.121	-0.347
18	-2.184	-1.121	-2.5	1.247
19	-2.184	-2.057	-1.518	1.264
20	-1.59	-1.328	1.044	-0.369
21	0.994	-0.99	-1.272	-0.437
22	-1.518	-1.032	-1.388	1.155

Standard thresholds

P-value	Threshold
0.001	-3.64719
0.0005	-1.99139
0.0001	1.55491