ONEC2.H12INVIVO.1.PM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ONEC2.H12INVIVO.1.PM.A
Gene (human)	ONECUT2 (GeneCards)
Gene synonyms (human)	HNF6B
Gene (mouse)	Onecut2
Gene synonyms (mouse)	Oc2
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	A

Motif length	14
Consensus	ndTATTGATTdnhn
GC content	26.01%
Information content (bits; total / per base)	14.77 / 1.055
Data sources	ChIP-Seq + Methyl-HT-SELEX
Aligned words	9890

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	4 (22)	0.821	0.946	0.707	0.91	0.815	0.888	3.199	3.764	52.44	226.201
Mouse	2 (12)	0.966	0.98	0.936	0.958	0.928	0.947	4.221	4.461	545.618	653.347

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 8 experiments	median	0.989	0.983	0.944	0.932	0.893	0.874
Overall, 8 experiments	best	0.999	0.999	0.999	0.998	0.997	0.994
Methyl HT-SELEX, 3 experiments	median	0.998	0.996	0.997	0.995	0.996	0.994
Methyl HT-SELEX, 3 experiments	best	0.999	0.999	0.999	0.998	0.997	0.994
Non-Methyl HT-SELEX, 5 experiments	median	0.94	0.906	0.907	0.867	0.809	0.786
Non-Methyl HT-SELEX, 5 experiments	best	0.992	0.986	0.983	0.974	0.982	0.969

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	HD-CUT {3.1.9} (TFClass)
TF subfamily	ONECUT {3.1.9.1} (TFClass)
TFClass ID	TFClass: 3.1.9.1.2
HGNC	HGNC:8139
MGI	MGI:1891408
EntrezGene (human)	GeneID:9480 (SSTAR profile)
EntrezGene (mouse)	GeneID:225631 (SSTAR profile)
UniProt ID (human)	ONEC2_HUMAN
UniProt ID (mouse)	ONEC2_MOUSE
UniProt AC (human)	O95948 (TFClass)
UniProt AC (mouse)	Q6XBJ3 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	4 human, 2 mouse
HT-SELEX	5
Methyl-HT-SELEX	3

PCM	ONEC2.H12INVIVO.1.PM.A.pcm
PWM	ONEC2.H12INVIVO.1.PM.A.pwm
PFM	ONEC2.H12INVIVO.1.PM.A.pfm
Alignment	ONEC2.H12INVIVO.1.PM.A.words.tsv
Threshold to P-value map	ONEC2.H12INVIVO.1.PM.A.thr
Motif in other formats
JASPAR format	ONEC2.H12INVIVO.1.PM.A_jaspar_format.txt
MEME format	ONEC2.H12INVIVO.1.PM.A_meme_format.meme
Transfac format	ONEC2.H12INVIVO.1.PM.A_transfac_format.txt
Homer format	ONEC2.H12INVIVO.1.PM.A_homer_format_0.001.txt ONEC2.H12INVIVO.1.PM.A_homer_format_0.0005.txt ONEC2.H12INVIVO.1.PM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2985.25	1456.25	2406.25	3042.25
02	1768.0	1158.0	2499.0	4465.0
03	249.0	335.0	268.0	9038.0
04	9883.0	1.0	2.0	4.0
05	1.0	2.0	1.0	9886.0
06	0.0	88.0	0.0	9802.0
07	0.0	0.0	9890.0	0.0
08	9851.0	3.0	35.0	1.0
09	30.0	192.0	24.0	9644.0
10	52.0	2251.0	122.0	7465.0
11	2618.0	1038.0	2337.0	3897.0
12	2894.0	1678.0	2013.0	3305.0
13	1862.0	2549.0	1360.0	4119.0
14	2214.5	2109.5	2200.5	3365.5

PFM

	A	C	G	T
01	0.302	0.147	0.243	0.308
02	0.179	0.117	0.253	0.451
03	0.025	0.034	0.027	0.914
04	0.999	0.0	0.0	0.0
05	0.0	0.0	0.0	1.0
06	0.0	0.009	0.0	0.991
07	0.0	0.0	1.0	0.0
08	0.996	0.0	0.004	0.0
09	0.003	0.019	0.002	0.975
10	0.005	0.228	0.012	0.755
11	0.265	0.105	0.236	0.394
12	0.293	0.17	0.204	0.334
13	0.188	0.258	0.138	0.416
14	0.224	0.213	0.222	0.34

PWM

	A	C	G	T
01	0.188	-0.529	-0.027	0.207
02	-0.335	-0.757	0.011	0.591
03	-2.287	-1.993	-2.214	1.296
04	1.385	-6.62	-6.355	-5.973
05	-6.62	-6.355	-6.62	1.385
06	-6.981	-3.311	-6.981	1.377
07	-6.981	-6.981	1.386	-6.981
08	1.382	-6.146	-4.195	-6.62
09	-4.339	-2.545	-4.544	1.36
10	-3.819	-0.094	-2.991	1.104
11	0.057	-0.867	-0.056	0.455
12	0.157	-0.387	-0.205	0.29
13	-0.283	0.03	-0.597	0.51
14	-0.11	-0.159	-0.116	0.308

Standard thresholds

P-value	Threshold
0.001	0.99396
0.0005	2.53336
0.0001	6.25756