ONEC2.H12INVITRO.1.PM.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ONEC2.H12INVITRO.1.PM.A
Gene (human)	ONECUT2 (GeneCards)
Gene synonyms (human)	HNF6B
Gene (mouse)	Onecut2
Gene synonyms (mouse)	Oc2
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	A

Motif length	13
Consensus	nbTATTGATYddb
GC content	28.63%
Information content (bits; total / per base)	15.55 / 1.196
Data sources	ChIP-Seq + Methyl-HT-SELEX
Aligned words	2353

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	4 (22)	0.811	0.931	0.704	0.894	0.798	0.863	2.746	3.215	51.255	220.013
Mouse	2 (12)	0.977	0.988	0.95	0.971	0.924	0.949	4.086	4.338	536.594	622.678

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 8 experiments	median	0.987	0.977	0.961	0.938	0.908	0.893
Overall, 8 experiments	best	0.998	0.997	0.998	0.996	0.997	0.994
Methyl HT-SELEX, 3 experiments	median	0.998	0.996	0.997	0.995	0.996	0.994
Methyl HT-SELEX, 3 experiments	best	0.998	0.997	0.998	0.996	0.997	0.994
Non-Methyl HT-SELEX, 5 experiments	median	0.96	0.932	0.937	0.905	0.831	0.815
Non-Methyl HT-SELEX, 5 experiments	best	0.993	0.988	0.992	0.986	0.992	0.985

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	HD-CUT {3.1.9} (TFClass)
TF subfamily	ONECUT {3.1.9.1} (TFClass)
TFClass ID	TFClass: 3.1.9.1.2
HGNC	HGNC:8139
MGI	MGI:1891408
EntrezGene (human)	GeneID:9480 (SSTAR profile)
EntrezGene (mouse)	GeneID:225631 (SSTAR profile)
UniProt ID (human)	ONEC2_HUMAN
UniProt ID (mouse)	ONEC2_MOUSE
UniProt AC (human)	O95948 (TFClass)
UniProt AC (mouse)	Q6XBJ3 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	4 human, 2 mouse
HT-SELEX	5
Methyl-HT-SELEX	3

PCM	ONEC2.H12INVITRO.1.PM.A.pcm
PWM	ONEC2.H12INVITRO.1.PM.A.pwm
PFM	ONEC2.H12INVITRO.1.PM.A.pfm
Alignment	ONEC2.H12INVITRO.1.PM.A.words.tsv
Threshold to P-value map	ONEC2.H12INVITRO.1.PM.A.thr
Motif in other formats
JASPAR format	ONEC2.H12INVITRO.1.PM.A_jaspar_format.txt
MEME format	ONEC2.H12INVITRO.1.PM.A_meme_format.meme
Transfac format	ONEC2.H12INVITRO.1.PM.A_transfac_format.txt
Homer format	ONEC2.H12INVITRO.1.PM.A_homer_format_0.001.txt ONEC2.H12INVITRO.1.PM.A_homer_format_0.0005.txt ONEC2.H12INVITRO.1.PM.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	693.25	488.25	646.25	525.25
02	254.0	262.0	867.0	970.0
03	26.0	47.0	66.0	2214.0
04	2353.0	0.0	0.0	0.0
05	0.0	0.0	0.0	2353.0
06	0.0	31.0	0.0	2322.0
07	0.0	0.0	2353.0	0.0
08	2353.0	0.0	0.0	0.0
09	0.0	8.0	1.0	2344.0
10	5.0	949.0	3.0	1396.0
11	590.0	143.0	1269.0	351.0
12	1215.25	256.25	515.25	366.25
13	311.75	456.75	396.75	1187.75

PFM

	A	C	G	T
01	0.295	0.208	0.275	0.223
02	0.108	0.111	0.368	0.412
03	0.011	0.02	0.028	0.941
04	1.0	0.0	0.0	0.0
05	0.0	0.0	0.0	1.0
06	0.0	0.013	0.0	0.987
07	0.0	0.0	1.0	0.0
08	1.0	0.0	0.0	0.0
09	0.0	0.003	0.0	0.996
10	0.002	0.403	0.001	0.593
11	0.251	0.061	0.539	0.149
12	0.516	0.109	0.219	0.156
13	0.132	0.194	0.169	0.505

PWM

	A	C	G	T
01	0.164	-0.186	0.094	-0.113
02	-0.835	-0.805	0.387	0.499
03	-3.05	-2.49	-2.162	1.323
04	1.384	-5.717	-5.717	-5.717
05	-5.717	-5.717	-5.717	1.384
06	-5.717	-2.886	-5.717	1.371
07	-5.717	-5.717	1.384	-5.717
08	1.384	-5.717	-5.717	-5.717
09	-5.717	-4.084	-5.302	1.38
10	-4.443	0.477	-4.783	0.862
11	0.003	-1.404	0.767	-0.514
12	0.724	-0.827	-0.132	-0.472
13	-0.632	-0.252	-0.392	0.701

Standard thresholds

P-value	Threshold
0.001	0.38366
0.0005	2.31353
0.0001	5.559125