ONEC2.H12INVITRO.0.S.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ONEC2.H12INVITRO.0.S.B
Gene (human)	ONECUT2 (GeneCards)
Gene synonyms (human)	HNF6B
Gene (mouse)	Onecut2
Gene synonyms (mouse)	Oc2
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	12
Consensus	ndTATCGATYdn
GC content	33.35%
Information content (bits; total / per base)	13.387 / 1.116
Data sources	HT-SELEX
Aligned words	8132

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	4 (22)	0.83	0.941	0.743	0.913	0.826	0.908	2.706	3.37	60.293	182.602
Mouse	2 (12)	0.984	0.99	0.956	0.967	0.948	0.952	3.489	3.546	587.733	671.18

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 8 experiments	median	0.986	0.974	0.978	0.964	0.915	0.911
Overall, 8 experiments	best	0.998	0.997	0.998	0.997	0.998	0.996
Methyl HT-SELEX, 3 experiments	median	0.99	0.98	0.991	0.981	0.992	0.983
Methyl HT-SELEX, 3 experiments	best	0.993	0.986	0.994	0.988	0.994	0.988
Non-Methyl HT-SELEX, 5 experiments	median	0.983	0.968	0.964	0.947	0.838	0.839
Non-Methyl HT-SELEX, 5 experiments	best	0.998	0.997	0.998	0.997	0.998	0.996

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	HD-CUT {3.1.9} (TFClass)
TF subfamily	ONECUT {3.1.9.1} (TFClass)
TFClass ID	TFClass: 3.1.9.1.2
HGNC	HGNC:8139
MGI	MGI:1891408
EntrezGene (human)	GeneID:9480 (SSTAR profile)
EntrezGene (mouse)	GeneID:225631 (SSTAR profile)
UniProt ID (human)	ONEC2_HUMAN
UniProt ID (mouse)	ONEC2_MOUSE
UniProt AC (human)	O95948 (TFClass)
UniProt AC (mouse)	Q6XBJ3 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	4 human, 2 mouse
HT-SELEX	5
Methyl-HT-SELEX	3

PCM	ONEC2.H12INVITRO.0.S.B.pcm
PWM	ONEC2.H12INVITRO.0.S.B.pwm
PFM	ONEC2.H12INVITRO.0.S.B.pfm
Alignment	ONEC2.H12INVITRO.0.S.B.words.tsv
Threshold to P-value map	ONEC2.H12INVITRO.0.S.B.thr
Motif in other formats
JASPAR format	ONEC2.H12INVITRO.0.S.B_jaspar_format.txt
MEME format	ONEC2.H12INVITRO.0.S.B_meme_format.meme
Transfac format	ONEC2.H12INVITRO.0.S.B_transfac_format.txt
Homer format	ONEC2.H12INVITRO.0.S.B_homer_format_0.001.txt ONEC2.H12INVITRO.0.S.B_homer_format_0.0005.txt ONEC2.H12INVITRO.0.S.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2953.5	1093.5	2096.5	1988.5
02	1917.25	752.25	1627.25	3835.25
03	599.0	502.0	440.0	6591.0
04	7974.0	48.0	26.0	84.0
05	1.0	4.0	5.0	8122.0
06	0.0	7441.0	0.0	691.0
07	4.0	2.0	8126.0	0.0
08	8116.0	10.0	5.0	1.0
09	107.0	199.0	65.0	7761.0
10	55.0	3411.0	107.0	4559.0
11	1428.5	1192.5	2133.5	3377.5
12	1765.0	1552.0	1707.0	3108.0

PFM

	A	C	G	T
01	0.363	0.134	0.258	0.245
02	0.236	0.093	0.2	0.472
03	0.074	0.062	0.054	0.811
04	0.981	0.006	0.003	0.01
05	0.0	0.0	0.001	0.999
06	0.0	0.915	0.0	0.085
07	0.0	0.0	0.999	0.0
08	0.998	0.001	0.001	0.0
09	0.013	0.024	0.008	0.954
10	0.007	0.419	0.013	0.561
11	0.176	0.147	0.262	0.415
12	0.217	0.191	0.21	0.382

PWM

	A	C	G	T
01	0.373	-0.619	0.031	-0.022
02	-0.059	-0.992	-0.222	0.634
03	-1.219	-1.395	-1.526	1.175
04	1.366	-3.701	-4.277	-3.161
05	-6.439	-5.786	-5.637	1.384
06	-6.807	1.297	-6.807	-1.077
07	-5.786	-6.171	1.385	-6.807
08	1.383	-5.113	-5.637	-6.439
09	-2.925	-2.314	-3.41	1.339
10	-3.571	0.517	-2.925	0.807
11	-0.352	-0.533	0.048	0.507
12	-0.141	-0.27	-0.175	0.424

Standard thresholds

P-value	Threshold
0.001	2.650615
0.0005	3.99846
0.0001	7.094075