ONEC2.H12CORE.2.S.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	ONEC2.H12CORE.2.S.B
Gene (human)	ONECUT2 (GeneCards)
Gene synonyms (human)	HNF6B
Gene (mouse)	Onecut2
Gene synonyms (mouse)	Oc2
LOGO
LOGO (reverse complement)
Motif subtype	2
Quality	B

Motif length	13
Consensus	nbTATCGATCGvb
GC content	43.97%
Information content (bits; total / per base)	16.095 / 1.238
Data sources	HT-SELEX
Aligned words	9457

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	4 (22)	0.804	0.929	0.726	0.901	0.746	0.842	2.039	2.682	18.516	54.444
Mouse	2 (12)	0.981	0.99	0.951	0.971	0.911	0.917	3.09	3.234	359.208	405.155

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 8 experiments	median	0.99	0.982	0.98	0.97	0.928	0.922
Overall, 8 experiments	best	1.0	0.999	0.999	0.999	0.999	0.998
Methyl HT-SELEX, 3 experiments	median	0.993	0.989	0.991	0.984	0.99	0.982
Methyl HT-SELEX, 3 experiments	best	0.996	0.994	0.993	0.989	0.991	0.986
Non-Methyl HT-SELEX, 5 experiments	median	0.986	0.976	0.97	0.956	0.867	0.861
Non-Methyl HT-SELEX, 5 experiments	best	1.0	0.999	0.999	0.999	0.999	0.998

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	HD-CUT {3.1.9} (TFClass)
TF subfamily	ONECUT {3.1.9.1} (TFClass)
TFClass ID	TFClass: 3.1.9.1.2
HGNC	HGNC:8139
MGI	MGI:1891408
EntrezGene (human)	GeneID:9480 (SSTAR profile)
EntrezGene (mouse)	GeneID:225631 (SSTAR profile)
UniProt ID (human)	ONEC2_HUMAN
UniProt ID (mouse)	ONEC2_MOUSE
UniProt AC (human)	O95948 (TFClass)
UniProt AC (mouse)	Q6XBJ3 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	4 human, 2 mouse
HT-SELEX	5
Methyl-HT-SELEX	3

PCM	ONEC2.H12CORE.2.S.B.pcm
PWM	ONEC2.H12CORE.2.S.B.pwm
PFM	ONEC2.H12CORE.2.S.B.pfm
Alignment	ONEC2.H12CORE.2.S.B.words.tsv
Threshold to P-value map	ONEC2.H12CORE.2.S.B.thr
Motif in other formats
JASPAR format	ONEC2.H12CORE.2.S.B_jaspar_format.txt
MEME format	ONEC2.H12CORE.2.S.B_meme_format.meme
Transfac format	ONEC2.H12CORE.2.S.B_transfac_format.txt
Homer format	ONEC2.H12CORE.2.S.B_homer_format_0.001.txt ONEC2.H12CORE.2.S.B_homer_format_0.0005.txt ONEC2.H12CORE.2.S.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2268.5	2317.5	2856.5	2014.5
02	1133.25	1585.25	3033.25	3705.25
03	823.0	191.0	751.0	7692.0
04	9457.0	0.0	0.0	0.0
05	0.0	0.0	0.0	9457.0
06	0.0	9415.0	0.0	42.0
07	0.0	0.0	9457.0	0.0
08	9457.0	0.0	0.0	0.0
09	0.0	4.0	0.0	9453.0
10	10.0	8166.0	4.0	1277.0
11	481.0	612.0	7898.0	466.0
12	4267.0	1083.0	3106.0	1001.0
13	1374.5	1826.5	1753.5	4502.5

PFM

	A	C	G	T
01	0.24	0.245	0.302	0.213
02	0.12	0.168	0.321	0.392
03	0.087	0.02	0.079	0.813
04	1.0	0.0	0.0	0.0
05	0.0	0.0	0.0	1.0
06	0.0	0.996	0.0	0.004
07	0.0	0.0	1.0	0.0
08	1.0	0.0	0.0	0.0
09	0.0	0.0	0.0	1.0
10	0.001	0.863	0.0	0.135
11	0.051	0.065	0.835	0.049
12	0.451	0.115	0.328	0.106
13	0.145	0.193	0.185	0.476

PWM

	A	C	G	T
01	-0.041	-0.02	0.189	-0.16
02	-0.734	-0.399	0.249	0.449
03	-1.053	-2.505	-1.145	1.179
04	1.386	-6.941	-6.941	-6.941
05	-6.941	-6.941	-6.941	1.386
06	-6.941	1.381	-6.941	-3.978
07	-6.941	-6.941	1.386	-6.941
08	1.386	-6.941	-6.941	-6.941
09	-6.941	-5.93	-6.941	1.385
10	-5.261	1.239	-5.93	-0.615
11	-1.589	-1.349	1.205	-1.62
12	0.59	-0.78	0.273	-0.858
13	-0.542	-0.258	-0.299	0.644

Standard thresholds

P-value	Threshold
0.001	-0.85723
0.0005	0.86357
0.0001	5.00828