OLIG2.H12INVIVO.1.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	OLIG2.H12INVIVO.1.P.B
Gene (human)	OLIG2 (GeneCards)
Gene synonyms (human)	BHLHB1, BHLHE19, PRKCBP2, RACK17
Gene (mouse)	Olig2
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	9
Consensus	MMWKCTGbY
GC content	55.29%
Information content (bits; total / per base)	8.475 / 0.942
Data sources	ChIP-Seq
Aligned words	998

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	8 (40)	0.728	0.8	0.609	0.68	0.653	0.724	1.742	2.008	45.7	101.143
Mouse	9 (60)	0.852	0.898	0.728	0.795	0.776	0.837	2.119	2.472	121.351	220.602

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 8 experiments	median	0.822	0.753	0.733	0.689	0.649	0.631
Overall, 8 experiments	best	0.928	0.863	0.919	0.863	0.831	0.796
Methyl HT-SELEX, 2 experiments	median	0.916	0.854	0.895	0.838	0.816	0.776
Methyl HT-SELEX, 2 experiments	best	0.928	0.863	0.919	0.863	0.831	0.796
Non-Methyl HT-SELEX, 6 experiments	median	0.732	0.672	0.67	0.629	0.6	0.594
Non-Methyl HT-SELEX, 6 experiments	best	0.899	0.829	0.878	0.815	0.8	0.756

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	2.182	1.104	0.372	0.177

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.809	0.139	0.859	0.601
batch 2	0.613	0.349	0.615	0.431

TF superclass	Basic domains {1} (TFClass)
TF class	Basic helix-loop-helix factors (bHLH) {1.2} (TFClass)
TF family	Tal-related {1.2.3} (TFClass)
TF subfamily	Neurogenin-ATO {1.2.3.4} (TFClass)
TFClass ID	TFClass: 1.2.3.4.14
HGNC	HGNC:9398
MGI	MGI:1355331
EntrezGene (human)	GeneID:10215 (SSTAR profile)
EntrezGene (mouse)	GeneID:50913 (SSTAR profile)
UniProt ID (human)	OLIG2_HUMAN
UniProt ID (mouse)	OLIG2_MOUSE
UniProt AC (human)	Q13516 (TFClass)
UniProt AC (mouse)	Q9EQW6 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	8 human, 9 mouse
HT-SELEX	6
Methyl-HT-SELEX	2

PCM	OLIG2.H12INVIVO.1.P.B.pcm
PWM	OLIG2.H12INVIVO.1.P.B.pwm
PFM	OLIG2.H12INVIVO.1.P.B.pfm
Alignment	OLIG2.H12INVIVO.1.P.B.words.tsv
Threshold to P-value map	OLIG2.H12INVIVO.1.P.B.thr
Motif in other formats
JASPAR format	OLIG2.H12INVIVO.1.P.B_jaspar_format.txt
MEME format	OLIG2.H12INVIVO.1.P.B_meme_format.meme
Transfac format	OLIG2.H12INVIVO.1.P.B_transfac_format.txt
Homer format	OLIG2.H12INVIVO.1.P.B_homer_format_0.001.txt OLIG2.H12INVIVO.1.P.B_homer_format_0.0005.txt OLIG2.H12INVIVO.1.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	231.0	622.0	92.0	53.0
02	221.0	735.0	27.0	15.0
03	747.0	29.0	106.0	116.0
04	24.0	15.0	583.0	376.0
05	132.0	795.0	57.0	14.0
06	4.0	2.0	5.0	987.0
07	6.0	23.0	937.0	32.0
08	14.0	363.0	245.0	376.0
09	80.0	253.0	77.0	588.0

PFM

	A	C	G	T
01	0.231	0.623	0.092	0.053
02	0.221	0.736	0.027	0.015
03	0.748	0.029	0.106	0.116
04	0.024	0.015	0.584	0.377
05	0.132	0.797	0.057	0.014
06	0.004	0.002	0.005	0.989
07	0.006	0.023	0.939	0.032
08	0.014	0.364	0.245	0.377
09	0.08	0.254	0.077	0.589

PWM

	A	C	G	T
01	-0.076	0.909	-0.986	-1.524
02	-0.12	1.076	-2.169	-2.709
03	1.092	-2.101	-0.847	-0.758
04	-2.279	-2.709	0.845	0.408
05	-0.631	1.154	-1.453	-2.771
06	-3.781	-4.211	-3.62	1.37
07	-3.482	-2.318	1.318	-2.008
08	-2.771	0.373	-0.018	0.408
09	-1.123	0.014	-1.16	0.853

Standard thresholds

P-value	Threshold
0.001	5.062775
0.0005	5.82062
0.0001	7.17139