OLIG2.H12INVITRO.1.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	OLIG2.H12INVITRO.1.P.B
Gene (human)	OLIG2 (GeneCards)
Gene synonyms (human)	BHLHB1, BHLHE19, PRKCBP2, RACK17
Gene (mouse)	Olig2
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	B

Motif length	10
Consensus	MCAKCTGbYb
GC content	52.26%
Information content (bits; total / per base)	10.37 / 1.037
Data sources	ChIP-Seq
Aligned words	1000

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	8 (40)	0.715	0.788	0.572	0.642	0.646	0.735	1.668	2.032	45.243	102.745
Mouse	9 (60)	0.836	0.879	0.7	0.759	0.793	0.848	2.369	2.63	124.496	210.854

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 8 experiments	median	0.848	0.792	0.743	0.708	0.652	0.641
Overall, 8 experiments	best	0.963	0.924	0.946	0.912	0.845	0.827
Methyl HT-SELEX, 2 experiments	median	0.947	0.902	0.919	0.879	0.828	0.801
Methyl HT-SELEX, 2 experiments	best	0.963	0.924	0.946	0.912	0.845	0.827
Non-Methyl HT-SELEX, 6 experiments	median	0.75	0.695	0.678	0.641	0.604	0.6
Non-Methyl HT-SELEX, 6 experiments	best	0.943	0.893	0.9	0.857	0.805	0.777

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	3.107	1.972	0.358	0.169

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.857	0.184	0.896	0.625
batch 2	0.608	0.364	0.634	0.454

TF superclass	Basic domains {1} (TFClass)
TF class	Basic helix-loop-helix factors (bHLH) {1.2} (TFClass)
TF family	Tal-related {1.2.3} (TFClass)
TF subfamily	Neurogenin-ATO {1.2.3.4} (TFClass)
TFClass ID	TFClass: 1.2.3.4.14
HGNC	HGNC:9398
MGI	MGI:1355331
EntrezGene (human)	GeneID:10215 (SSTAR profile)
EntrezGene (mouse)	GeneID:50913 (SSTAR profile)
UniProt ID (human)	OLIG2_HUMAN
UniProt ID (mouse)	OLIG2_MOUSE
UniProt AC (human)	Q13516 (TFClass)
UniProt AC (mouse)	Q9EQW6 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	8 human, 9 mouse
HT-SELEX	6
Methyl-HT-SELEX	2

PCM	OLIG2.H12INVITRO.1.P.B.pcm
PWM	OLIG2.H12INVITRO.1.P.B.pwm
PFM	OLIG2.H12INVITRO.1.P.B.pfm
Alignment	OLIG2.H12INVITRO.1.P.B.words.tsv
Threshold to P-value map	OLIG2.H12INVITRO.1.P.B.thr
Motif in other formats
JASPAR format	OLIG2.H12INVITRO.1.P.B_jaspar_format.txt
MEME format	OLIG2.H12INVITRO.1.P.B_meme_format.meme
Transfac format	OLIG2.H12INVITRO.1.P.B_transfac_format.txt
Homer format	OLIG2.H12INVITRO.1.P.B_homer_format_0.001.txt OLIG2.H12INVITRO.1.P.B_homer_format_0.0005.txt OLIG2.H12INVITRO.1.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	203.0	684.0	89.0	24.0
02	139.0	854.0	2.0	5.0
03	873.0	22.0	17.0	88.0
04	12.0	16.0	399.0	573.0
05	154.0	811.0	22.0	13.0
06	5.0	2.0	2.0	991.0
07	3.0	8.0	964.0	25.0
08	12.0	396.0	189.0	403.0
09	43.0	209.0	36.0	712.0
10	100.0	305.0	199.0	396.0

PFM

	A	C	G	T
01	0.203	0.684	0.089	0.024
02	0.139	0.854	0.002	0.005
03	0.873	0.022	0.017	0.088
04	0.012	0.016	0.399	0.573
05	0.154	0.811	0.022	0.013
06	0.005	0.002	0.002	0.991
07	0.003	0.008	0.964	0.025
08	0.012	0.396	0.189	0.403
09	0.043	0.209	0.036	0.712
10	0.1	0.305	0.199	0.396

PWM

	A	C	G	T
01	-0.207	1.002	-1.02	-2.281
02	-0.582	1.224	-4.213	-3.622
03	1.246	-2.362	-2.598	-1.032
04	-2.909	-2.653	0.465	0.826
05	-0.48	1.172	-2.362	-2.839
06	-3.622	-4.213	-4.213	1.372
07	-3.975	-3.253	1.345	-2.243
08	-2.909	0.457	-0.278	0.475
09	-1.728	-0.178	-1.898	1.042
10	-0.906	0.198	-0.226	0.457

Standard thresholds

P-value	Threshold
0.001	4.67597
0.0005	5.56404
0.0001	7.45076