NRF1.H12INVITRO.0.PS.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	NRF1.H12INVITRO.0.PS.A
Gene (human)	NRF1 (GeneCards)
Gene synonyms (human)
Gene (mouse)	Nrf1
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	A

Motif length	16
Consensus	nbnbYGCGCAbGCKCv
GC content	68.31%
Information content (bits; total / per base)	15.524 / 0.97
Data sources	ChIP-Seq + HT-SELEX
Aligned words	1000

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	20 (135)	0.987	0.994	0.963	0.982	0.985	0.995	6.027	6.662	489.469	733.721
Mouse	14 (87)	0.987	0.996	0.967	0.992	0.985	0.992	5.994	6.404	513.62	828.161

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Non-Methyl HT-SELEX, 2 experiments	median	0.862	0.865	0.752	0.763	0.632	0.659
Non-Methyl HT-SELEX, 2 experiments	best	1.0	1.0	0.885	0.899	0.696	0.742

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	1.991	6.932	0.155	0.095

TF superclass	Yet undefined DNA-binding domains {0} (TFClass)
TF class	Uncharacterized {0.0} (TFClass)
TF family	NRF {0.0.6} (TFClass)
TF subfamily	{0.0.6.0} (TFClass)
TFClass ID	TFClass: 0.0.6.0.1
HGNC	HGNC:7996
MGI	MGI:1332235
EntrezGene (human)	GeneID:4899 (SSTAR profile)
EntrezGene (mouse)	GeneID:18181 (SSTAR profile)
UniProt ID (human)	NRF1_HUMAN
UniProt ID (mouse)	NRF1_MOUSE
UniProt AC (human)	Q16656 (TFClass)
UniProt AC (mouse)	Q9WU00 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	20 human, 14 mouse
HT-SELEX	2
Methyl-HT-SELEX	0

PCM	NRF1.H12INVITRO.0.PS.A.pcm
PWM	NRF1.H12INVITRO.0.PS.A.pwm
PFM	NRF1.H12INVITRO.0.PS.A.pfm
Alignment	NRF1.H12INVITRO.0.PS.A.words.tsv
Threshold to P-value map	NRF1.H12INVITRO.0.PS.A.thr
Motif in other formats
JASPAR format	NRF1.H12INVITRO.0.PS.A_jaspar_format.txt
MEME format	NRF1.H12INVITRO.0.PS.A_meme_format.meme
Transfac format	NRF1.H12INVITRO.0.PS.A_transfac_format.txt
Homer format	NRF1.H12INVITRO.0.PS.A_homer_format_0.001.txt NRF1.H12INVITRO.0.PS.A_homer_format_0.0005.txt NRF1.H12INVITRO.0.PS.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	190.0	311.0	279.0	220.0
02	159.0	394.0	208.0	239.0
03	232.0	312.0	264.0	192.0
04	103.0	495.0	238.0	164.0
05	54.0	161.0	36.0	749.0
06	83.0	3.0	914.0	0.0
07	7.0	987.0	6.0	0.0
08	7.0	2.0	988.0	3.0
09	0.0	1000.0	0.0	0.0
10	985.0	1.0	13.0	1.0
11	78.0	133.0	327.0	462.0
12	26.0	42.0	913.0	19.0
13	41.0	854.0	9.0	96.0
14	30.0	64.0	753.0	153.0
15	6.0	778.0	34.0	182.0
16	471.0	201.0	210.0	118.0

PFM

	A	C	G	T
01	0.19	0.311	0.279	0.22
02	0.159	0.394	0.208	0.239
03	0.232	0.312	0.264	0.192
04	0.103	0.495	0.238	0.164
05	0.054	0.161	0.036	0.749
06	0.083	0.003	0.914	0.0
07	0.007	0.987	0.006	0.0
08	0.007	0.002	0.988	0.003
09	0.0	1.0	0.0	0.0
10	0.985	0.001	0.013	0.001
11	0.078	0.133	0.327	0.462
12	0.026	0.042	0.913	0.019
13	0.041	0.854	0.009	0.096
14	0.03	0.064	0.753	0.153
15	0.006	0.778	0.034	0.182
16	0.471	0.201	0.21	0.118

PWM

	A	C	G	T
01	-0.272	0.217	0.109	-0.127
02	-0.449	0.452	-0.183	-0.045
03	-0.074	0.22	0.054	-0.262
04	-0.877	0.68	-0.049	-0.418
05	-1.508	-0.436	-1.898	1.093
06	-1.089	-3.975	1.291	-4.982
07	-3.362	1.368	-3.484	-4.982
08	-3.362	-4.213	1.369	-3.975
09	-4.982	1.381	-4.982	-4.982
10	1.366	-4.525	-2.839	-4.525
11	-1.15	-0.625	0.267	0.611
12	-2.206	-1.75	1.29	-2.497
13	-1.774	1.224	-3.156	-0.946
14	-2.071	-1.343	1.098	-0.487
15	-3.484	1.131	-1.952	-0.315
16	0.63	-0.216	-0.173	-0.743

Standard thresholds

P-value	Threshold
0.001	2.37146
0.0005	3.68056
0.0001	6.38696