MotifNR4A1.H12INVITRO.0.PSM.A
Gene (human)NR4A1
(GeneCards)
Gene synonyms (human)GFRP1, HMR, NAK1
Gene (mouse)Nr4a1
Gene synonyms (mouse)Gfrp, Hmr, N10, Nur77
LOGO
LOGO (reverse complement)
Motif subtype0
Quality
A
Motif length8
ConsensusAAAGGTCA
GC content37.59%
Information content (bits; total / per base)13.108 / 1.639
Data sourcesChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words998

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 2 (14) 0.882 0.915 0.83 0.87 0.867 0.894 2.88 3.018 216.266 254.796
Mouse 1 (5) 0.902 0.925 0.832 0.862 0.89 0.911 2.955 3.097 318.678 333.481

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 4 experiments median 0.998 0.998 0.995 0.994 0.974 0.969
best 1.0 1.0 0.999 0.999 0.998 0.997
Methyl HT-SELEX, 2 experiments median 0.998 0.998 0.995 0.994 0.974 0.969
best 0.999 0.998 0.996 0.995 0.984 0.98
Non-Methyl HT-SELEX, 2 experiments median 0.998 0.997 0.991 0.988 0.966 0.96
best 1.0 1.0 0.999 0.999 0.998 0.997

rSNP benchmarking, SNP-SELEX auROC auPRC Pearson r Kendall tau
batch 2 0.614 0.081 0.53 0.324
TF superclassZinc-coordinating DNA-binding domains {2} (TFClass)
TF classNuclear receptors with C4 zinc fingers {2.1} (TFClass)
TF familyNGFI (NR4A) {2.1.4} (TFClass)
TF subfamily {2.1.4.0} (TFClass)
TFClass IDTFClass: 2.1.4.0.1
HGNCHGNC:7980
MGIMGI:1352454
EntrezGene (human)GeneID:3164
(SSTAR profile)
EntrezGene (mouse)GeneID:15370
(SSTAR profile)
UniProt ID (human)NR4A1_HUMAN
UniProt ID (mouse)NR4A1_MOUSE
UniProt AC (human)P22736
(TFClass)
UniProt AC (mouse)P12813
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 2 human, 1 mouse
HT-SELEX 2
Methyl-HT-SELEX 2
PCM
ACGT
01904.02.064.028.0
02968.01.017.012.0
03992.01.04.01.0
042.02.0806.0188.0
051.01.0984.012.0
067.060.072.0859.0
071.0963.00.034.0
08970.018.06.04.0
PFM
ACGT
010.9060.0020.0640.028
020.970.0010.0170.012
030.9940.0010.0040.001
040.0020.0020.8080.188
050.0010.0010.9860.012
060.0070.060.0720.861
070.0010.9650.00.034
080.9720.0180.0060.004
PWM
ACGT
011.282-4.211-1.341-2.134
021.351-4.523-2.596-2.907
031.375-4.523-3.781-4.523
04-4.211-4.2111.168-0.281
05-4.523-4.5231.367-2.907
06-3.36-1.404-1.2261.231
07-4.5231.345-4.98-1.95
081.353-2.544-3.482-3.781
Standard thresholds
P-value Threshold
0.001 3.17379
0.0005 4.59167
0.0001 6.84626