NR2F6.H12INVITRO.2.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	NR2F6.H12INVITRO.2.SM.B
Gene (human)	NR2F6 (GeneCards)
Gene synonyms (human)	EAR2, ERBAL2
Gene (mouse)	Nr2f6
Gene synonyms (mouse)	Ear-2, Ear2, Erbal2
LOGO
LOGO (reverse complement)
Motif subtype	2
Quality	B

Motif length	15
Consensus	nvRGGTCAWRRGKbv
GC content	50.19%
Information content (bits; total / per base)	14.676 / 0.978
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	2475

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	3 (21)	0.852	0.863	0.725	0.741	0.844	0.857	2.942	3.277	198.071	231.456

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 11 experiments	median	0.928	0.904	0.857	0.825	0.752	0.736
Overall, 11 experiments	best	1.0	0.999	0.997	0.995	0.98	0.972
Methyl HT-SELEX, 3 experiments	median	0.995	0.992	0.988	0.982	0.963	0.955
Methyl HT-SELEX, 3 experiments	best	0.999	0.999	0.991	0.988	0.974	0.963
Non-Methyl HT-SELEX, 8 experiments	median	0.787	0.783	0.656	0.664	0.581	0.598
Non-Methyl HT-SELEX, 8 experiments	best	1.0	0.999	0.997	0.995	0.98	0.972

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	Nuclear receptors with C4 zinc fingers {2.1} (TFClass)
TF family	RXR-related receptors {2.1.3} (TFClass)
TF subfamily	COUP (NR2F) {2.1.3.5} (TFClass)
TFClass ID	TFClass: 2.1.3.5.3
HGNC	HGNC:7977
MGI	MGI:1352453
EntrezGene (human)	GeneID:2063 (SSTAR profile)
EntrezGene (mouse)	GeneID:13864 (SSTAR profile)
UniProt ID (human)	NR2F6_HUMAN
UniProt ID (mouse)	NR2F6_MOUSE
UniProt AC (human)	P10588 (TFClass)
UniProt AC (mouse)	P43136 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	3 human, 0 mouse
HT-SELEX	8
Methyl-HT-SELEX	3

PCM	NR2F6.H12INVITRO.2.SM.B.pcm
PWM	NR2F6.H12INVITRO.2.SM.B.pwm
PFM	NR2F6.H12INVITRO.2.SM.B.pfm
Alignment	NR2F6.H12INVITRO.2.SM.B.words.tsv
Threshold to P-value map	NR2F6.H12INVITRO.2.SM.B.thr
Motif in other formats
JASPAR format	NR2F6.H12INVITRO.2.SM.B_jaspar_format.txt
MEME format	NR2F6.H12INVITRO.2.SM.B_meme_format.meme
Transfac format	NR2F6.H12INVITRO.2.SM.B_transfac_format.txt
Homer format	NR2F6.H12INVITRO.2.SM.B_homer_format_0.001.txt NR2F6.H12INVITRO.2.SM.B_homer_format_0.0005.txt NR2F6.H12INVITRO.2.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	947.5	560.5	404.5	562.5
02	917.0	274.0	1027.0	257.0
03	1774.0	52.0	620.0	29.0
04	5.0	28.0	2398.0	44.0
05	5.0	20.0	2439.0	11.0
06	2.0	3.0	18.0	2452.0
07	1.0	2383.0	7.0	84.0
08	2441.0	1.0	32.0	1.0
09	1456.0	229.0	192.0	598.0
10	1826.0	56.0	488.0	105.0
11	517.0	87.0	1791.0	80.0
12	175.0	194.0	2014.0	92.0
13	92.0	208.0	628.0	1547.0
14	202.75	1105.75	396.75	769.75
15	1101.5	505.5	471.5	396.5

PFM

	A	C	G	T
01	0.383	0.226	0.163	0.227
02	0.371	0.111	0.415	0.104
03	0.717	0.021	0.251	0.012
04	0.002	0.011	0.969	0.018
05	0.002	0.008	0.985	0.004
06	0.001	0.001	0.007	0.991
07	0.0	0.963	0.003	0.034
08	0.986	0.0	0.013	0.0
09	0.588	0.093	0.078	0.242
10	0.738	0.023	0.197	0.042
11	0.209	0.035	0.724	0.032
12	0.071	0.078	0.814	0.037
13	0.037	0.084	0.254	0.625
14	0.082	0.447	0.16	0.311
15	0.445	0.204	0.191	0.16

PWM

	A	C	G	T
01	0.425	-0.099	-0.423	-0.095
02	0.392	-0.811	0.505	-0.874
03	1.051	-2.443	0.002	-2.998
04	-4.492	-3.031	1.352	-2.603
05	-4.492	-3.342	1.369	-3.869
06	-5.056	-4.831	-3.437	1.375
07	-5.348	1.346	-4.239	-1.977
08	1.37	-5.348	-2.906	-5.348
09	0.854	-0.989	-1.163	-0.034
10	1.08	-2.371	-0.237	-1.758
11	-0.179	-1.943	1.061	-2.025
12	-1.255	-1.153	1.178	-1.888
13	-1.888	-1.084	0.015	0.914
14	-1.109	0.579	-0.443	0.218
15	0.575	-0.201	-0.271	-0.443

Standard thresholds

P-value	Threshold
0.001	2.74911
0.0005	4.01541
0.0001	6.63061