NR2F6.H12CORE.3.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	NR2F6.H12CORE.3.SM.B
Gene (human)	NR2F6 (GeneCards)
Gene synonyms (human)	EAR2, ERBAL2
Gene (mouse)	Nr2f6
Gene synonyms (mouse)	Ear-2, Ear2, Erbal2
LOGO
LOGO (reverse complement)
Motif subtype	3
Quality	B

Motif length	16
Consensus	hRAGGTCAdhGRYYhn
GC content	49.88%
Information content (bits; total / per base)	14.871 / 0.929
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	2468

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	3 (21)	0.871	0.879	0.746	0.76	0.832	0.847	2.577	2.691	195.367	217.367

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 11 experiments	median	0.958	0.95	0.874	0.853	0.717	0.731
Overall, 11 experiments	best	1.0	1.0	1.0	0.999	0.997	0.997
Methyl HT-SELEX, 3 experiments	median	0.995	0.992	0.988	0.983	0.975	0.965
Methyl HT-SELEX, 3 experiments	best	1.0	1.0	1.0	0.999	0.997	0.997
Non-Methyl HT-SELEX, 8 experiments	median	0.819	0.813	0.661	0.68	0.579	0.605
Non-Methyl HT-SELEX, 8 experiments	best	0.997	0.996	0.994	0.991	0.984	0.978

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	Nuclear receptors with C4 zinc fingers {2.1} (TFClass)
TF family	RXR-related receptors {2.1.3} (TFClass)
TF subfamily	COUP (NR2F) {2.1.3.5} (TFClass)
TFClass ID	TFClass: 2.1.3.5.3
HGNC	HGNC:7977
MGI	MGI:1352453
EntrezGene (human)	GeneID:2063 (SSTAR profile)
EntrezGene (mouse)	GeneID:13864 (SSTAR profile)
UniProt ID (human)	NR2F6_HUMAN
UniProt ID (mouse)	NR2F6_MOUSE
UniProt AC (human)	P10588 (TFClass)
UniProt AC (mouse)	P43136 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	3 human, 0 mouse
HT-SELEX	8
Methyl-HT-SELEX	3

PCM	NR2F6.H12CORE.3.SM.B.pcm
PWM	NR2F6.H12CORE.3.SM.B.pwm
PFM	NR2F6.H12CORE.3.SM.B.pfm
Alignment	NR2F6.H12CORE.3.SM.B.words.tsv
Threshold to P-value map	NR2F6.H12CORE.3.SM.B.thr
Motif in other formats
JASPAR format	NR2F6.H12CORE.3.SM.B_jaspar_format.txt
MEME format	NR2F6.H12CORE.3.SM.B_meme_format.meme
Transfac format	NR2F6.H12CORE.3.SM.B_transfac_format.txt
Homer format	NR2F6.H12CORE.3.SM.B_homer_format_0.001.txt NR2F6.H12CORE.3.SM.B_homer_format_0.0005.txt NR2F6.H12CORE.3.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1061.75	465.75	386.75	553.75
02	1695.75	100.75	459.75	211.75
03	2261.0	1.0	205.0	1.0
04	0.0	0.0	2468.0	0.0
05	1.0	0.0	2467.0	0.0
06	0.0	0.0	4.0	2464.0
07	0.0	2405.0	9.0	54.0
08	2050.0	2.0	414.0	2.0
09	1121.0	411.0	443.0	493.0
10	664.0	527.0	281.0	996.0
11	251.0	155.0	1985.0	77.0
12	1390.0	191.0	753.0	134.0
13	141.0	1453.0	176.0	698.0
14	181.0	1896.0	156.0	235.0
15	542.5	484.5	295.5	1145.5
16	559.25	660.25	443.25	805.25

PFM

	A	C	G	T
01	0.43	0.189	0.157	0.224
02	0.687	0.041	0.186	0.086
03	0.916	0.0	0.083	0.0
04	0.0	0.0	1.0	0.0
05	0.0	0.0	1.0	0.0
06	0.0	0.0	0.002	0.998
07	0.0	0.974	0.004	0.022
08	0.831	0.001	0.168	0.001
09	0.454	0.167	0.179	0.2
10	0.269	0.214	0.114	0.404
11	0.102	0.063	0.804	0.031
12	0.563	0.077	0.305	0.054
13	0.057	0.589	0.071	0.283
14	0.073	0.768	0.063	0.095
15	0.22	0.196	0.12	0.464
16	0.227	0.268	0.18	0.326

PWM

	A	C	G	T
01	0.541	-0.28	-0.465	-0.108
02	1.009	-1.796	-0.293	-1.063
03	1.296	-5.345	-1.096	-5.345
04	-5.759	-5.759	1.384	-5.759
05	-5.345	-5.759	1.384	-5.759
06	-5.759	-5.759	-4.644	1.382
07	-5.759	1.358	-4.034	-2.404
08	1.199	-5.054	-0.397	-5.054
09	0.596	-0.405	-0.33	-0.224
10	0.073	-0.157	-0.783	0.478
11	-0.895	-1.372	1.166	-2.059
12	0.81	-1.166	0.199	-1.516
13	-1.466	0.855	-1.247	0.123
14	-1.219	1.121	-1.366	-0.96
15	-0.128	-0.241	-0.733	0.617
16	-0.098	0.068	-0.329	0.266

Standard thresholds

P-value	Threshold
0.001	2.17971
0.0005	3.67646
0.0001	6.64861