NR2F6.H12CORE.2.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	NR2F6.H12CORE.2.SM.B
Gene (human)	NR2F6 (GeneCards)
Gene synonyms (human)	EAR2, ERBAL2
Gene (mouse)	Nr2f6
Gene synonyms (mouse)	Ear-2, Ear2, Erbal2
LOGO
LOGO (reverse complement)
Motif subtype	2
Quality	B

Motif length	18
Consensus	nvKKKYMWAGGTCAhdvn
GC content	51.58%
Information content (bits; total / per base)	15.475 / 0.86
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	1485

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	3 (21)	0.874	0.895	0.788	0.814	0.842	0.871	3.197	3.384	201.444	250.102

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 11 experiments	median	0.929	0.909	0.816	0.798	0.68	0.691
Overall, 11 experiments	best	1.0	0.999	0.995	0.994	0.98	0.973
Methyl HT-SELEX, 3 experiments	median	0.997	0.995	0.991	0.987	0.973	0.967
Methyl HT-SELEX, 3 experiments	best	1.0	0.999	0.995	0.994	0.976	0.968
Non-Methyl HT-SELEX, 8 experiments	median	0.796	0.796	0.671	0.677	0.595	0.609
Non-Methyl HT-SELEX, 8 experiments	best	0.998	0.997	0.993	0.99	0.98	0.973

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	Nuclear receptors with C4 zinc fingers {2.1} (TFClass)
TF family	RXR-related receptors {2.1.3} (TFClass)
TF subfamily	COUP (NR2F) {2.1.3.5} (TFClass)
TFClass ID	TFClass: 2.1.3.5.3
HGNC	HGNC:7977
MGI	MGI:1352453
EntrezGene (human)	GeneID:2063 (SSTAR profile)
EntrezGene (mouse)	GeneID:13864 (SSTAR profile)
UniProt ID (human)	NR2F6_HUMAN
UniProt ID (mouse)	NR2F6_MOUSE
UniProt AC (human)	P10588 (TFClass)
UniProt AC (mouse)	P43136 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	3 human, 0 mouse
HT-SELEX	8
Methyl-HT-SELEX	3

PCM	NR2F6.H12CORE.2.SM.B.pcm
PWM	NR2F6.H12CORE.2.SM.B.pwm
PFM	NR2F6.H12CORE.2.SM.B.pfm
Alignment	NR2F6.H12CORE.2.SM.B.words.tsv
Threshold to P-value map	NR2F6.H12CORE.2.SM.B.thr
Motif in other formats
JASPAR format	NR2F6.H12CORE.2.SM.B_jaspar_format.txt
MEME format	NR2F6.H12CORE.2.SM.B_meme_format.meme
Transfac format	NR2F6.H12CORE.2.SM.B_transfac_format.txt
Homer format	NR2F6.H12CORE.2.SM.B_homer_format_0.001.txt NR2F6.H12CORE.2.SM.B_homer_format_0.0005.txt NR2F6.H12CORE.2.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	482.0	273.0	476.0	254.0
02	684.5	174.5	527.5	98.5
03	130.0	131.0	1085.0	139.0
04	77.0	134.0	1108.0	166.0
05	60.0	180.0	275.0	970.0
06	79.0	974.0	145.0	287.0
07	1149.0	124.0	103.0	109.0
08	1165.0	12.0	149.0	159.0
09	1407.0	3.0	73.0	2.0
10	0.0	0.0	1483.0	2.0
11	1.0	0.0	1480.0	4.0
12	0.0	11.0	24.0	1450.0
13	4.0	1334.0	49.0	98.0
14	1195.0	10.0	258.0	22.0
15	440.0	331.0	196.0	518.0
16	290.0	216.0	648.0	331.0
17	347.5	211.5	715.5	210.5
18	365.75	337.75	535.75	245.75

PFM

	A	C	G	T
01	0.325	0.184	0.321	0.171
02	0.461	0.118	0.355	0.066
03	0.088	0.088	0.731	0.094
04	0.052	0.09	0.746	0.112
05	0.04	0.121	0.185	0.653
06	0.053	0.656	0.098	0.193
07	0.774	0.084	0.069	0.073
08	0.785	0.008	0.1	0.107
09	0.947	0.002	0.049	0.001
10	0.0	0.0	0.999	0.001
11	0.001	0.0	0.997	0.003
12	0.0	0.007	0.016	0.976
13	0.003	0.898	0.033	0.066
14	0.805	0.007	0.174	0.015
15	0.296	0.223	0.132	0.349
16	0.195	0.145	0.436	0.223
17	0.234	0.142	0.482	0.142
18	0.246	0.227	0.361	0.165

PWM

	A	C	G	T
01	0.26	-0.306	0.247	-0.377
02	0.61	-0.749	0.35	-1.313
03	-1.04	-1.033	1.069	-0.974
04	-1.555	-1.01	1.09	-0.799
05	-1.797	-0.719	-0.298	0.957
06	-1.529	0.962	-0.933	-0.256
07	1.126	-1.087	-1.269	-1.214
08	1.14	-3.295	-0.906	-0.841
09	1.329	-4.348	-1.607	-4.58
10	-5.32	-5.32	1.381	-4.58
11	-4.883	-5.32	1.379	-4.159
12	-5.32	-3.37	-2.67	1.359
13	-4.159	1.276	-1.993	-1.318
14	1.166	-3.451	-0.362	-2.751
15	0.169	-0.114	-0.634	0.332
16	-0.246	-0.538	0.555	-0.114
17	-0.066	-0.559	0.654	-0.564
18	-0.015	-0.094	0.365	-0.41

Standard thresholds

P-value	Threshold
0.001	2.61551
0.0005	3.88496
0.0001	6.48086