MotifNR2F6.H12CORE.1.PSM.A
Gene (human)NR2F6
(GeneCards)
Gene synonyms (human)EAR2, ERBAL2
Gene (mouse)Nr2f6
Gene synonyms (mouse)Ear-2, Ear2, Erbal2
LOGO
LOGO (reverse complement)
Motif subtype1
Quality
A
Motif length12
ConsensusnddRGGTCRnnn
GC content50.31%
Information content (bits; total / per base)8.787 / 0.732
Data sourcesChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words9816

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 3 (21) 0.89 0.905 0.793 0.812 0.866 0.885 3.005 3.155 253.046 308.959

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 11 experiments median 0.957 0.935 0.899 0.871 0.78 0.77
best 0.999 0.998 0.993 0.99 0.982 0.973
Methyl HT-SELEX, 3 experiments median 0.99 0.984 0.985 0.976 0.975 0.962
best 0.996 0.995 0.992 0.988 0.98 0.973
Non-Methyl HT-SELEX, 8 experiments median 0.812 0.813 0.667 0.682 0.591 0.61
best 0.999 0.998 0.993 0.99 0.982 0.973
TF superclassZinc-coordinating DNA-binding domains {2} (TFClass)
TF classNuclear receptors with C4 zinc fingers {2.1} (TFClass)
TF familyRXR-related receptors {2.1.3} (TFClass)
TF subfamilyCOUP (NR2F) {2.1.3.5} (TFClass)
TFClass IDTFClass: 2.1.3.5.3
HGNCHGNC:7977
MGIMGI:1352453
EntrezGene (human)GeneID:2063
(SSTAR profile)
EntrezGene (mouse)GeneID:13864
(SSTAR profile)
UniProt ID (human)NR2F6_HUMAN
UniProt ID (mouse)NR2F6_MOUSE
UniProt AC (human)P10588
(TFClass)
UniProt AC (mouse)P43136
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 3 human, 0 mouse
HT-SELEX 8
Methyl-HT-SELEX 3
PCM
ACGT
012137.03421.02309.01949.0
024713.751546.751931.751623.75
034691.0867.03250.01008.0
046766.0288.02309.0453.0
0529.047.09617.0123.0
0657.059.09568.0132.0
0750.083.0190.09493.0
08233.08137.0873.0573.0
097140.0529.01590.0557.0
103339.01580.01758.03139.0
113233.251255.252927.252400.25
122339.751484.753641.752349.75
PFM
ACGT
010.2180.3490.2350.199
020.480.1580.1970.165
030.4780.0880.3310.103
040.6890.0290.2350.046
050.0030.0050.980.013
060.0060.0060.9750.013
070.0050.0080.0190.967
080.0240.8290.0890.058
090.7270.0540.1620.057
100.340.1610.1790.32
110.3290.1280.2980.245
120.2380.1510.3710.239
PWM
ACGT
01-0.1380.332-0.061-0.23
020.652-0.461-0.239-0.413
030.647-1.0390.281-0.888
041.014-2.136-0.061-1.685
05-4.363-3.9091.365-2.976
06-3.724-3.6911.36-2.906
07-3.849-3.36-2.5471.352
08-2.3461.198-1.032-1.452
091.067-1.531-0.433-1.48
100.308-0.44-0.3330.246
110.276-0.6690.176-0.022
12-0.048-0.5020.394-0.043
Standard thresholds
P-value Threshold
0.001 5.06346
0.0005 5.84567
0.0001 7.35383