NR2F6.H12CORE.0.P.C motif - HOmo sapiens COmprehensive MOdel COllection

Motif	NR2F6.H12CORE.0.P.C
Gene (human)	NR2F6 (GeneCards)
Gene synonyms (human)	EAR2, ERBAL2
Gene (mouse)	Nr2f6
Gene synonyms (mouse)	Ear-2, Ear2, Erbal2
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	C

Motif length	14
Consensus	dddvbvWRAGGTCA
GC content	52.66%
Information content (bits; total / per base)	11.966 / 0.855
Data sources	ChIP-Seq
Aligned words	1000

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	3 (21)	0.894	0.907	0.808	0.83	0.877	0.891	3.418	3.687	218.495	291.796

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 11 experiments	median	0.927	0.9	0.844	0.813	0.73	0.72
Overall, 11 experiments	best	0.999	0.999	0.992	0.991	0.977	0.968
Methyl HT-SELEX, 3 experiments	median	0.992	0.988	0.985	0.977	0.965	0.956
Methyl HT-SELEX, 3 experiments	best	0.997	0.997	0.99	0.986	0.97	0.957
Non-Methyl HT-SELEX, 8 experiments	median	0.795	0.796	0.656	0.67	0.574	0.599
Non-Methyl HT-SELEX, 8 experiments	best	0.999	0.999	0.992	0.991	0.977	0.968

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	Nuclear receptors with C4 zinc fingers {2.1} (TFClass)
TF family	RXR-related receptors {2.1.3} (TFClass)
TF subfamily	COUP (NR2F) {2.1.3.5} (TFClass)
TFClass ID	TFClass: 2.1.3.5.3
HGNC	HGNC:7977
MGI	MGI:1352453
EntrezGene (human)	GeneID:2063 (SSTAR profile)
EntrezGene (mouse)	GeneID:13864 (SSTAR profile)
UniProt ID (human)	NR2F6_HUMAN
UniProt ID (mouse)	NR2F6_MOUSE
UniProt AC (human)	P10588 (TFClass)
UniProt AC (mouse)	P43136 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	3 human, 0 mouse
HT-SELEX	8
Methyl-HT-SELEX	3

PCM	NR2F6.H12CORE.0.P.C.pcm
PWM	NR2F6.H12CORE.0.P.C.pwm
PFM	NR2F6.H12CORE.0.P.C.pfm
Alignment	NR2F6.H12CORE.0.P.C.words.tsv
Threshold to P-value map	NR2F6.H12CORE.0.P.C.thr
Motif in other formats
JASPAR format	NR2F6.H12CORE.0.P.C_jaspar_format.txt
MEME format	NR2F6.H12CORE.0.P.C_meme_format.meme
Transfac format	NR2F6.H12CORE.0.P.C_transfac_format.txt
Homer format	NR2F6.H12CORE.0.P.C_homer_format_0.001.txt NR2F6.H12CORE.0.P.C_homer_format_0.0005.txt NR2F6.H12CORE.0.P.C_homer_format_0.0001.txt

PCM

	A	C	G	T
01	271.0	140.0	424.0	165.0
02	430.0	98.0	336.0	136.0
03	176.0	131.0	536.0	157.0
04	162.0	197.0	492.0	149.0
05	139.0	252.0	192.0	417.0
06	153.0	573.0	145.0	129.0
07	716.0	95.0	83.0	106.0
08	472.0	52.0	436.0	40.0
09	819.0	1.0	179.0	1.0
10	6.0	0.0	988.0	6.0
11	17.0	6.0	961.0	16.0
12	1.0	34.0	54.0	911.0
13	3.0	900.0	30.0	67.0
14	947.0	17.0	21.0	15.0

PFM

	A	C	G	T
01	0.271	0.14	0.424	0.165
02	0.43	0.098	0.336	0.136
03	0.176	0.131	0.536	0.157
04	0.162	0.197	0.492	0.149
05	0.139	0.252	0.192	0.417
06	0.153	0.573	0.145	0.129
07	0.716	0.095	0.083	0.106
08	0.472	0.052	0.436	0.04
09	0.819	0.001	0.179	0.001
10	0.006	0.0	0.988	0.006
11	0.017	0.006	0.961	0.016
12	0.001	0.034	0.054	0.911
13	0.003	0.9	0.03	0.067
14	0.947	0.017	0.021	0.015

PWM

	A	C	G	T
01	0.08	-0.574	0.525	-0.412
02	0.539	-0.926	0.294	-0.603
03	-0.348	-0.64	0.759	-0.461
04	-0.43	-0.236	0.674	-0.513
05	-0.582	0.008	-0.262	0.509
06	-0.487	0.826	-0.54	-0.655
07	1.048	-0.956	-1.089	-0.849
08	0.632	-1.544	0.553	-1.797
09	1.182	-4.525	-0.331	-4.525
10	-3.484	-4.982	1.369	-3.484
11	-2.598	-3.484	1.341	-2.653
12	-4.525	-1.952	-1.508	1.288
13	-3.975	1.276	-2.071	-1.298
14	1.327	-2.598	-2.405	-2.711

Standard thresholds

P-value	Threshold
0.001	4.16621
0.0005	5.17386
0.0001	7.23996