NR2C2.H12INVITRO.1.PS.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	NR2C2.H12INVITRO.1.PS.A
Gene (human)	NR2C2 (GeneCards)
Gene synonyms (human)	TAK1, TR4
Gene (mouse)	Nr2c2
Gene synonyms (mouse)	Mtr2r1, Tak1, Tr4
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	A

Motif length	15
Consensus	ddKdYhWRAGGTYRn
GC content	48.76%
Information content (bits; total / per base)	9.945 / 0.663
Data sources	ChIP-Seq + HT-SELEX
Aligned words	9839

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	4 (27)	0.636	0.82	0.586	0.767	0.639	0.822	2.751	3.758	43.638	117.237

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.967	0.96	0.883	0.856	0.739	0.747
Overall, 4 experiments	best	1.0	1.0	0.945	0.947	0.871	0.851
Methyl HT-SELEX, 1 experiments	median	0.979	0.969	0.945	0.927	0.871	0.851
Methyl HT-SELEX, 1 experiments	best	0.979	0.969	0.945	0.927	0.871	0.851
Non-Methyl HT-SELEX, 3 experiments	median	0.955	0.952	0.821	0.785	0.717	0.701
Non-Methyl HT-SELEX, 3 experiments	best	1.0	1.0	0.945	0.947	0.761	0.792

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	Nuclear receptors with C4 zinc fingers {2.1} (TFClass)
TF family	RXR-related receptors {2.1.3} (TFClass)
TF subfamily	TR (NR2C) {2.1.3.4} (TFClass)
TFClass ID	TFClass: 2.1.3.4.2
HGNC	HGNC:7972
MGI	MGI:1352466
EntrezGene (human)	GeneID:7182 (SSTAR profile)
EntrezGene (mouse)	GeneID:22026 (SSTAR profile)
UniProt ID (human)	NR2C2_HUMAN
UniProt ID (mouse)	NR2C2_MOUSE
UniProt AC (human)	P49116 (TFClass)
UniProt AC (mouse)	P49117 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	4 human, 0 mouse
HT-SELEX	3
Methyl-HT-SELEX	1

PCM	NR2C2.H12INVITRO.1.PS.A.pcm
PWM	NR2C2.H12INVITRO.1.PS.A.pwm
PFM	NR2C2.H12INVITRO.1.PS.A.pfm
Alignment	NR2C2.H12INVITRO.1.PS.A.words.tsv
Threshold to P-value map	NR2C2.H12INVITRO.1.PS.A.thr
Motif in other formats
JASPAR format	NR2C2.H12INVITRO.1.PS.A_jaspar_format.txt
MEME format	NR2C2.H12INVITRO.1.PS.A_meme_format.meme
Transfac format	NR2C2.H12INVITRO.1.PS.A_transfac_format.txt
Homer format	NR2C2.H12INVITRO.1.PS.A_homer_format_0.001.txt NR2C2.H12INVITRO.1.PS.A_homer_format_0.0005.txt NR2C2.H12INVITRO.1.PS.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2826.75	1482.75	3642.75	1886.75
02	3647.25	975.25	3998.25	1218.25
03	1100.0	858.0	6474.0	1407.0
04	1150.0	989.0	5304.0	2396.0
05	1056.0	1521.0	1228.0	6034.0
06	1445.0	5296.0	1217.0	1881.0
07	7184.0	743.0	948.0	964.0
08	6015.0	479.0	2119.0	1226.0
09	7744.0	121.0	1827.0	147.0
10	145.0	105.0	9351.0	238.0
11	194.0	134.0	8002.0	1509.0
12	200.0	223.0	531.0	8885.0
13	365.0	7478.0	639.0	1357.0
14	6650.25	858.25	1485.25	845.25
15	3040.75	2321.75	1614.75	2861.75

PFM

	A	C	G	T
01	0.287	0.151	0.37	0.192
02	0.371	0.099	0.406	0.124
03	0.112	0.087	0.658	0.143
04	0.117	0.101	0.539	0.244
05	0.107	0.155	0.125	0.613
06	0.147	0.538	0.124	0.191
07	0.73	0.076	0.096	0.098
08	0.611	0.049	0.215	0.125
09	0.787	0.012	0.186	0.015
10	0.015	0.011	0.95	0.024
11	0.02	0.014	0.813	0.153
12	0.02	0.023	0.054	0.903
13	0.037	0.76	0.065	0.138
14	0.676	0.087	0.151	0.086
15	0.309	0.236	0.164	0.291

PWM

	A	C	G	T
01	0.139	-0.506	0.392	-0.265
02	0.394	-0.924	0.485	-0.702
03	-0.804	-1.051	0.967	-0.558
04	-0.759	-0.91	0.768	-0.026
05	-0.844	-0.48	-0.694	0.897
06	-0.531	0.766	-0.703	-0.268
07	1.071	-1.195	-0.952	-0.935
08	0.894	-1.632	-0.149	-0.695
09	1.146	-2.994	-0.297	-2.803
10	-2.816	-3.133	1.335	-2.327
11	-2.529	-2.894	1.179	-0.488
12	-2.499	-2.391	-1.53	1.284
13	-1.903	1.111	-1.345	-0.594
14	0.994	-1.051	-0.504	-1.066
15	0.212	-0.058	-0.42	0.151

Standard thresholds

P-value	Threshold
0.001	4.68821
0.0005	5.49231
0.0001	7.15671