| Motif | NR1I3.H12RSNP.2.M.C |
| Gene (human) | NR1I3 (GeneCards) |
| Gene synonyms (human) | CAR |
| Gene (mouse) | Nr1i3 |
| Gene synonyms (mouse) | Car |
| LOGO |  |
| LOGO (reverse complement) |  |
| Motif subtype | 2 |
| Quality | C |
| Motif | NR1I3.H12RSNP.2.M.C |
| Gene (human) | NR1I3 (GeneCards) |
| Gene synonyms (human) | CAR |
| Gene (mouse) | Nr1i3 |
| Gene synonyms (mouse) | Car |
| LOGO | |
| LOGO (reverse complement) | |
| Motif subtype | 2 |
| Quality | C |
| Motif length | 20 |
| Consensus | nnWWAGTTCGYbnRRvYYbn |
| GC content | 42.38% |
| Information content (bits; total / per base) | 16.093 / 0.805 |
| Data sources | Methyl-HT-SELEX |
| Aligned words | 609 |
| ChIP-Seq benchmarking | Num. of experiments (peaksets) | auROC, median | auROC, best | auPRC, median | auPRC, best | pseudo-auROC, median | pseudo-auROC, best | pseudo-log-auROC, median | pseudo-log-auROC, best | Centrality, median | Centrality, best |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Mouse | 6 (6) | 0.663 | 0.679 | 0.556 | 0.571 | 0.612 | 0.646 | 1.6 | 1.696 | 55.886 | 72.959 |
| HT-SELEX benchmarking | auROC10 | auPRC10 | auROC25 | auPRC25 | auROC50 | auPRC50 | |
|---|---|---|---|---|---|---|---|
| Overall, 2 experiments | median | 0.949 | 0.937 | 0.818 | 0.816 | 0.682 | 0.702 |
| best | 0.963 | 0.947 | 0.892 | 0.873 | 0.744 | 0.751 | |
| Methyl HT-SELEX, 1 experiments | median | 0.935 | 0.927 | 0.743 | 0.759 | 0.621 | 0.653 |
| best | 0.935 | 0.927 | 0.743 | 0.759 | 0.621 | 0.653 | |
| Non-Methyl HT-SELEX, 1 experiments | median | 0.963 | 0.947 | 0.892 | 0.873 | 0.744 | 0.751 |
| best | 0.963 | 0.947 | 0.892 | 0.873 | 0.744 | 0.751 | |
| rSNP benchmarking, SNP-SELEX | auROC | auPRC | Pearson r | Kendall tau |
|---|---|---|---|---|
| batch 2 | 0.523 | 0.099 | 0.203 | 0.242 |
| TF superclass | Zinc-coordinating DNA-binding domains {2} (TFClass) |
| TF class | Nuclear receptors with C4 zinc fingers {2.1} (TFClass) |
| TF family | Thyroid hormone receptor-related {2.1.2} (TFClass) |
| TF subfamily | VDR (NR1I) {2.1.2.4} (TFClass) |
| TFClass ID | TFClass: 2.1.2.4.3 |
| HGNC | HGNC:7969 |
| MGI | MGI:1346307 |
| EntrezGene (human) | GeneID:9970 (SSTAR profile) |
| EntrezGene (mouse) | GeneID:12355 (SSTAR profile) |
| UniProt ID (human) | NR1I3_HUMAN |
| UniProt ID (mouse) | NR1I3_MOUSE |
| UniProt AC (human) | Q14994 (TFClass) |
| UniProt AC (mouse) | O35627 (TFClass) |
| GRECO-DB-TF | yes |
| ChIP-Seq | 0 human, 6 mouse |
| HT-SELEX | 1 |
| Methyl-HT-SELEX | 1 |
| PCM | NR1I3.H12RSNP.2.M.C.pcm |
| PWM | NR1I3.H12RSNP.2.M.C.pwm |
| PFM | NR1I3.H12RSNP.2.M.C.pfm |
| Alignment | NR1I3.H12RSNP.2.M.C.words.tsv |
| Threshold to P-value map | NR1I3.H12RSNP.2.M.C.thr |
| Motif in other formats | |
| JASPAR format | NR1I3.H12RSNP.2.M.C_jaspar_format.txt |
| MEME format | NR1I3.H12RSNP.2.M.C_meme_format.meme |
| Transfac format | NR1I3.H12RSNP.2.M.C_transfac_format.txt |
| Homer format | |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 115.25 | 171.25 | 167.25 | 155.25 |
| 02 | 78.5 | 188.5 | 154.5 | 187.5 |
| 03 | 416.0 | 33.0 | 58.0 | 102.0 |
| 04 | 373.0 | 13.0 | 101.0 | 122.0 |
| 05 | 609.0 | 0.0 | 0.0 | 0.0 |
| 06 | 0.0 | 0.0 | 609.0 | 0.0 |
| 07 | 0.0 | 0.0 | 0.0 | 609.0 |
| 08 | 0.0 | 0.0 | 0.0 | 609.0 |
| 09 | 0.0 | 609.0 | 0.0 | 0.0 |
| 10 | 156.0 | 0.0 | 453.0 | 0.0 |
| 11 | 69.0 | 248.0 | 18.0 | 274.0 |
| 12 | 77.0 | 128.0 | 196.0 | 208.0 |
| 13 | 138.0 | 146.0 | 228.0 | 97.0 |
| 14 | 370.0 | 27.0 | 158.0 | 54.0 |
| 15 | 470.0 | 47.0 | 71.0 | 21.0 |
| 16 | 188.0 | 186.0 | 182.0 | 53.0 |
| 17 | 42.0 | 110.0 | 88.0 | 369.0 |
| 18 | 44.0 | 72.0 | 45.0 | 448.0 |
| 19 | 69.25 | 222.25 | 72.25 | 245.25 |
| 20 | 127.0 | 173.0 | 187.0 | 122.0 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 0.189 | 0.281 | 0.275 | 0.255 |
| 02 | 0.129 | 0.31 | 0.254 | 0.308 |
| 03 | 0.683 | 0.054 | 0.095 | 0.167 |
| 04 | 0.612 | 0.021 | 0.166 | 0.2 |
| 05 | 1.0 | 0.0 | 0.0 | 0.0 |
| 06 | 0.0 | 0.0 | 1.0 | 0.0 |
| 07 | 0.0 | 0.0 | 0.0 | 1.0 |
| 08 | 0.0 | 0.0 | 0.0 | 1.0 |
| 09 | 0.0 | 1.0 | 0.0 | 0.0 |
| 10 | 0.256 | 0.0 | 0.744 | 0.0 |
| 11 | 0.113 | 0.407 | 0.03 | 0.45 |
| 12 | 0.126 | 0.21 | 0.322 | 0.342 |
| 13 | 0.227 | 0.24 | 0.374 | 0.159 |
| 14 | 0.608 | 0.044 | 0.259 | 0.089 |
| 15 | 0.772 | 0.077 | 0.117 | 0.034 |
| 16 | 0.309 | 0.305 | 0.299 | 0.087 |
| 17 | 0.069 | 0.181 | 0.144 | 0.606 |
| 18 | 0.072 | 0.118 | 0.074 | 0.736 |
| 19 | 0.114 | 0.365 | 0.119 | 0.403 |
| 20 | 0.209 | 0.284 | 0.307 | 0.2 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | -0.275 | 0.116 | 0.093 | 0.019 |
| 02 | -0.653 | 0.212 | 0.015 | 0.206 |
| 03 | 0.999 | -1.492 | -0.948 | -0.395 |
| 04 | 0.89 | -2.355 | -0.405 | -0.219 |
| 05 | 1.378 | -4.564 | -4.564 | -4.564 |
| 06 | -4.564 | -4.564 | 1.378 | -4.564 |
| 07 | -4.564 | -4.564 | -4.564 | 1.378 |
| 08 | -4.564 | -4.564 | -4.564 | 1.378 |
| 09 | -4.564 | 1.378 | -4.564 | -4.564 |
| 10 | 0.024 | -4.564 | 1.083 | -4.564 |
| 11 | -0.779 | 0.484 | -2.06 | 0.583 |
| 12 | -0.672 | -0.172 | 0.25 | 0.309 |
| 13 | -0.097 | -0.041 | 0.4 | -0.445 |
| 14 | 0.882 | -1.682 | 0.037 | -1.018 |
| 15 | 1.12 | -1.152 | -0.751 | -1.918 |
| 16 | 0.209 | 0.198 | 0.177 | -1.036 |
| 17 | -1.261 | -0.321 | -0.541 | 0.879 |
| 18 | -1.216 | -0.737 | -1.194 | 1.072 |
| 19 | -0.775 | 0.375 | -0.734 | 0.473 |
| 20 | -0.179 | 0.127 | 0.204 | -0.219 |
| P-value | Threshold |
|---|---|
| 0.001 | 1.80551 |
| 0.0005 | 3.20796 |
| 0.0001 | 6.24411 |