NR1H2.H12INVITRO.1.P.D motif - HOmo sapiens COmprehensive MOdel COllection

Motif	NR1H2.H12INVITRO.1.P.D
Gene (human)	NR1H2 (GeneCards)
Gene synonyms (human)	LXRB, NER, UNR
Gene (mouse)	Nr1h2
Gene synonyms (mouse)	Lxrb, Rip15, Unr, Unr2
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	D

Motif length	19
Consensus	bhvRGGTYAYhnnvSKbYR
GC content	52.47%
Information content (bits; total / per base)	12.062 / 0.635
Data sources	ChIP-Seq
Aligned words	992

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Mouse	1 (7)	0.891	0.897	0.83	0.843	0.853	0.863	4.029	4.204	159.959	175.959

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	Nuclear receptors with C4 zinc fingers {2.1} (TFClass)
TF family	Thyroid hormone receptor-related {2.1.2} (TFClass)
TF subfamily	LXR (NR1H) {2.1.2.7} (TFClass)
TFClass ID	TFClass: 2.1.2.7.2
HGNC	HGNC:7965
MGI	MGI:1352463
EntrezGene (human)	GeneID:7376 (SSTAR profile)
EntrezGene (mouse)	GeneID:22260 (SSTAR profile)
UniProt ID (human)	NR1H2_HUMAN
UniProt ID (mouse)	NR1H2_MOUSE
UniProt AC (human)	P55055 (TFClass)
UniProt AC (mouse)	Q60644 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 1 mouse
HT-SELEX	0
Methyl-HT-SELEX	0

PCM	NR1H2.H12INVITRO.1.P.D.pcm
PWM	NR1H2.H12INVITRO.1.P.D.pwm
PFM	NR1H2.H12INVITRO.1.P.D.pfm
Alignment	NR1H2.H12INVITRO.1.P.D.words.tsv
Threshold to P-value map	NR1H2.H12INVITRO.1.P.D.thr
Motif in other formats
JASPAR format	NR1H2.H12INVITRO.1.P.D_jaspar_format.txt
MEME format	NR1H2.H12INVITRO.1.P.D_meme_format.meme
Transfac format	NR1H2.H12INVITRO.1.P.D_transfac_format.txt
Homer format	NR1H2.H12INVITRO.1.P.D_homer_format_0.001.txt NR1H2.H12INVITRO.1.P.D_homer_format_0.0005.txt NR1H2.H12INVITRO.1.P.D_homer_format_0.0001.txt

PCM

	A	C	G	T
01	178.0	396.0	228.0	190.0
02	395.0	226.0	139.0	232.0
03	286.0	97.0	529.0	80.0
04	547.0	7.0	429.0	9.0
05	43.0	2.0	907.0	40.0
06	14.0	10.0	870.0	98.0
07	24.0	63.0	70.0	835.0
08	72.0	574.0	34.0	312.0
09	920.0	9.0	25.0	38.0
10	111.0	568.0	52.0	261.0
11	135.0	221.0	91.0	545.0
12	255.0	216.0	293.0	228.0
13	285.0	222.0	316.0	169.0
14	553.0	166.0	221.0	52.0
15	75.0	126.0	745.0	46.0
16	45.0	76.0	648.0	223.0
17	110.0	155.0	173.0	554.0
18	75.0	739.0	66.0	112.0
19	730.0	84.0	96.0	82.0

PFM

	A	C	G	T
01	0.179	0.399	0.23	0.192
02	0.398	0.228	0.14	0.234
03	0.288	0.098	0.533	0.081
04	0.551	0.007	0.432	0.009
05	0.043	0.002	0.914	0.04
06	0.014	0.01	0.877	0.099
07	0.024	0.064	0.071	0.842
08	0.073	0.579	0.034	0.315
09	0.927	0.009	0.025	0.038
10	0.112	0.573	0.052	0.263
11	0.136	0.223	0.092	0.549
12	0.257	0.218	0.295	0.23
13	0.287	0.224	0.319	0.17
14	0.557	0.167	0.223	0.052
15	0.076	0.127	0.751	0.046
16	0.045	0.077	0.653	0.225
17	0.111	0.156	0.174	0.558
18	0.076	0.745	0.067	0.113
19	0.736	0.085	0.097	0.083

PWM

	A	C	G	T
01	-0.329	0.465	-0.083	-0.264
02	0.463	-0.092	-0.574	-0.066
03	0.142	-0.928	0.754	-1.117
04	0.787	-3.354	0.545	-3.148
05	-1.72	-4.205	1.292	-1.789
06	-2.765	-3.059	1.25	-0.918
07	-2.273	-1.35	-1.248	1.209
08	-1.22	0.835	-1.945	0.228
09	1.306	-3.148	-2.235	-1.838
10	-0.795	0.825	-1.536	0.051
11	-0.602	-0.114	-0.991	0.784
12	0.028	-0.137	0.166	-0.083
13	0.138	-0.11	0.241	-0.38
14	0.798	-0.398	-0.114	-1.536
15	-1.18	-0.67	1.095	-1.655
16	-1.676	-1.167	0.956	-0.105
17	-0.804	-0.466	-0.357	0.8
18	-1.18	1.087	-1.305	-0.787
19	1.075	-1.069	-0.938	-1.093

Standard thresholds

P-value	Threshold
0.001	4.24391
0.0005	5.15296
0.0001	7.05516