NR1H2.H12INVITRO.0.P.D motif - HOmo sapiens COmprehensive MOdel COllection

Motif	NR1H2.H12INVITRO.0.P.D
Gene (human)	NR1H2 (GeneCards)
Gene synonyms (human)	LXRB, NER, UNR
Gene (mouse)	Nr1h2
Gene synonyms (mouse)	Lxrb, Rip15, Unr, Unr2
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	D

Motif length	18
Consensus	nnnnhRAGGTCAhhdnvv
GC content	52.21%
Information content (bits; total / per base)	11.057 / 0.614
Data sources	ChIP-Seq
Aligned words	992

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Mouse	1 (7)	0.9	0.905	0.799	0.807	0.871	0.878	2.985	3.077	152.638	180.824

TF superclass	Zinc-coordinating DNA-binding domains {2} (TFClass)
TF class	Nuclear receptors with C4 zinc fingers {2.1} (TFClass)
TF family	Thyroid hormone receptor-related {2.1.2} (TFClass)
TF subfamily	LXR (NR1H) {2.1.2.7} (TFClass)
TFClass ID	TFClass: 2.1.2.7.2
HGNC	HGNC:7965
MGI	MGI:1352463
EntrezGene (human)	GeneID:7376 (SSTAR profile)
EntrezGene (mouse)	GeneID:22260 (SSTAR profile)
UniProt ID (human)	NR1H2_HUMAN
UniProt ID (mouse)	NR1H2_MOUSE
UniProt AC (human)	P55055 (TFClass)
UniProt AC (mouse)	Q60644 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 1 mouse
HT-SELEX	0
Methyl-HT-SELEX	0

PCM	NR1H2.H12INVITRO.0.P.D.pcm
PWM	NR1H2.H12INVITRO.0.P.D.pwm
PFM	NR1H2.H12INVITRO.0.P.D.pfm
Alignment	NR1H2.H12INVITRO.0.P.D.words.tsv
Threshold to P-value map	NR1H2.H12INVITRO.0.P.D.thr
Motif in other formats
JASPAR format	NR1H2.H12INVITRO.0.P.D_jaspar_format.txt
MEME format	NR1H2.H12INVITRO.0.P.D_meme_format.meme
Transfac format	NR1H2.H12INVITRO.0.P.D_transfac_format.txt
Homer format	NR1H2.H12INVITRO.0.P.D_homer_format_0.001.txt NR1H2.H12INVITRO.0.P.D_homer_format_0.0005.txt NR1H2.H12INVITRO.0.P.D_homer_format_0.0001.txt

PCM

	A	C	G	T
01	252.0	225.0	243.0	272.0
02	315.0	207.0	291.0	179.0
03	202.0	332.0	205.0	253.0
04	177.0	364.0	186.0	265.0
05	436.0	197.0	113.0	246.0
06	317.0	68.0	560.0	47.0
07	683.0	2.0	304.0	3.0
08	14.0	1.0	973.0	4.0
09	3.0	3.0	958.0	28.0
10	6.0	13.0	41.0	932.0
11	23.0	782.0	10.0	177.0
12	986.0	1.0	1.0	4.0
13	177.0	476.0	91.0	248.0
14	196.0	194.0	140.0	462.0
15	236.0	177.0	401.0	178.0
16	291.0	259.0	250.0	192.0
17	390.0	256.0	231.0	115.0
18	126.0	239.0	529.0	98.0

PFM

	A	C	G	T
01	0.254	0.227	0.245	0.274
02	0.318	0.209	0.293	0.18
03	0.204	0.335	0.207	0.255
04	0.178	0.367	0.188	0.267
05	0.44	0.199	0.114	0.248
06	0.32	0.069	0.565	0.047
07	0.689	0.002	0.306	0.003
08	0.014	0.001	0.981	0.004
09	0.003	0.003	0.966	0.028
10	0.006	0.013	0.041	0.94
11	0.023	0.788	0.01	0.178
12	0.994	0.001	0.001	0.004
13	0.178	0.48	0.092	0.25
14	0.198	0.196	0.141	0.466
15	0.238	0.178	0.404	0.179
16	0.293	0.261	0.252	0.194
17	0.393	0.258	0.233	0.116
18	0.127	0.241	0.533	0.099

PWM

	A	C	G	T
01	0.016	-0.097	-0.02	0.092
02	0.238	-0.179	0.159	-0.323
03	-0.204	0.29	-0.189	0.02
04	-0.335	0.382	-0.285	0.066
05	0.561	-0.228	-0.778	-0.008
06	0.244	-1.276	0.811	-1.634
07	1.009	-4.205	0.202	-3.968
08	-2.765	-4.518	1.362	-3.776
09	-3.968	-3.968	1.346	-2.128
10	-3.476	-2.831	-1.766	1.319
11	-2.313	1.144	-3.059	-0.335
12	1.375	-4.518	-4.518	-3.776
13	-0.335	0.649	-0.991	0.0
14	-0.233	-0.244	-0.566	0.619
15	-0.049	-0.335	0.478	-0.329
16	0.159	0.043	0.008	-0.254
17	0.45	0.032	-0.071	-0.761
18	-0.67	-0.037	0.754	-0.918

Standard thresholds

P-value	Threshold
0.001	4.39791
0.0005	5.46346
0.0001	7.50781