NKX63.H12CORE.0.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	NKX63.H12CORE.0.SM.B
Gene (human)	NKX6-3 (GeneCards)
Gene synonyms (human)
Gene (mouse)	Nkx6-3
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	14
Consensus	nvWTTAATKASbbn
GC content	30.49%
Information content (bits; total / per base)	14.457 / 1.033
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	7231

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 2 experiments	median	0.99	0.983	0.982	0.972	0.964	0.949
Overall, 2 experiments	best	0.992	0.986	0.986	0.977	0.972	0.96
Methyl HT-SELEX, 1 experiments	median	0.987	0.979	0.979	0.967	0.955	0.938
Methyl HT-SELEX, 1 experiments	best	0.987	0.979	0.979	0.967	0.955	0.938
Non-Methyl HT-SELEX, 1 experiments	median	0.992	0.986	0.986	0.977	0.972	0.96
Non-Methyl HT-SELEX, 1 experiments	best	0.992	0.986	0.986	0.977	0.972	0.96

TF superclass	Helix-turn-helix domains {3} (TFClass)
TF class	Homeo domain factors {3.1} (TFClass)
TF family	NK-related {3.1.2} (TFClass)
TF subfamily	NK6 {3.1.2.19} (TFClass)
TFClass ID	TFClass: 3.1.2.19.3
HGNC	HGNC:26328
MGI	MGI:1921811
EntrezGene (human)	GeneID:157848 (SSTAR profile)
EntrezGene (mouse)	GeneID:74561 (SSTAR profile)
UniProt ID (human)	NKX63_HUMAN
UniProt ID (mouse)	NKX63_MOUSE
UniProt AC (human)	A6NJ46 (TFClass)
UniProt AC (mouse)	Q3UHX8 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 0 mouse
HT-SELEX	1
Methyl-HT-SELEX	1

PCM	NKX63.H12CORE.0.SM.B.pcm
PWM	NKX63.H12CORE.0.SM.B.pwm
PFM	NKX63.H12CORE.0.SM.B.pfm
Alignment	NKX63.H12CORE.0.SM.B.words.tsv
Threshold to P-value map	NKX63.H12CORE.0.SM.B.thr
Motif in other formats
JASPAR format	NKX63.H12CORE.0.SM.B_jaspar_format.txt
MEME format	NKX63.H12CORE.0.SM.B_meme_format.meme
Transfac format	NKX63.H12CORE.0.SM.B_transfac_format.txt
Homer format	NKX63.H12CORE.0.SM.B_homer_format_0.001.txt NKX63.H12CORE.0.SM.B_homer_format_0.0005.txt NKX63.H12CORE.0.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1670.0	2106.0	1170.0	2285.0
02	2986.75	1978.75	1141.75	1123.75
03	4849.0	585.0	716.0	1081.0
04	149.0	13.0	37.0	7032.0
05	0.0	2.0	0.0	7229.0
06	7231.0	0.0	0.0	0.0
07	7231.0	0.0	0.0	0.0
08	0.0	1.0	0.0	7230.0
09	0.0	26.0	3882.0	3323.0
10	6845.0	0.0	386.0	0.0
11	48.0	4366.0	2624.0	193.0
12	673.0	3173.0	2152.0	1233.0
13	919.0	2545.0	1080.0	2687.0
14	1893.5	1801.5	1076.5	2459.5

PFM

	A	C	G	T
01	0.231	0.291	0.162	0.316
02	0.413	0.274	0.158	0.155
03	0.671	0.081	0.099	0.149
04	0.021	0.002	0.005	0.972
05	0.0	0.0	0.0	1.0
06	1.0	0.0	0.0	0.0
07	1.0	0.0	0.0	0.0
08	0.0	0.0	0.0	1.0
09	0.0	0.004	0.537	0.46
10	0.947	0.0	0.053	0.0
11	0.007	0.604	0.363	0.027
12	0.093	0.439	0.298	0.171
13	0.127	0.352	0.149	0.372
14	0.262	0.249	0.149	0.34

PWM

	A	C	G	T
01	-0.079	0.153	-0.434	0.234
02	0.502	0.09	-0.459	-0.475
03	0.986	-1.126	-0.924	-0.513
04	-2.482	-4.778	-3.832	1.357
05	-6.703	-6.061	-6.703	1.385
06	1.385	-6.703	-6.703	-6.703
07	1.385	-6.703	-6.703	-6.703
08	-6.703	-6.331	-6.703	1.385
09	-6.703	-4.161	0.764	0.608
10	1.331	-6.703	-1.539	-6.703
11	-3.585	0.881	0.372	-2.227
12	-0.986	0.562	0.174	-0.382
13	-0.675	0.342	-0.514	0.396
14	0.046	-0.003	-0.518	0.308

Standard thresholds

P-value	Threshold
0.001	0.95701
0.0005	2.54656
0.0001	6.435615