MotifNKX31.H12INVITRO.0.PSM.A
Gene (human)NKX3-1
(GeneCards)
Gene synonyms (human)NKX3.1, NKX3A
Gene (mouse)Nkx3-1
Gene synonyms (mouse)Nkx-3.1, Nkx3a
LOGO
LOGO (reverse complement)
Motif subtype0
Quality
A
Motif length14
ConsensusnYTAAGTGSbhhhh
GC content41.87%
Information content (bits; total / per base)13.218 / 0.944
Data sourcesChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words9937

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 3 (20) 0.695 0.772 0.513 0.62 0.614 0.687 1.404 1.718 39.689 101.886
Mouse 1 (5) 0.671 0.688 0.481 0.497 0.556 0.572 1.194 1.248 43.523 63.585

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 6 experiments median 0.97 0.957 0.909 0.895 0.812 0.815
best 0.998 0.996 0.989 0.986 0.977 0.967
Methyl HT-SELEX, 1 experiments median 0.992 0.987 0.988 0.981 0.977 0.967
best 0.992 0.987 0.988 0.981 0.977 0.967
Non-Methyl HT-SELEX, 5 experiments median 0.953 0.938 0.841 0.826 0.71 0.717
best 0.998 0.996 0.989 0.986 0.954 0.935
TF superclassHelix-turn-helix domains {3} (TFClass)
TF classHomeo domain factors {3.1} (TFClass)
TF familyNK-related {3.1.2} (TFClass)
TF subfamilyNK3 {3.1.2.16} (TFClass)
TFClass IDTFClass: 3.1.2.16.1
HGNCHGNC:7838
MGIMGI:97352
EntrezGene (human)GeneID:4824
(SSTAR profile)
EntrezGene (mouse)GeneID:18095
(SSTAR profile)
UniProt ID (human)NKX31_HUMAN
UniProt ID (mouse)NKX31_MOUSE
UniProt AC (human)Q99801
(TFClass)
UniProt AC (mouse)P97436
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 3 human, 1 mouse
HT-SELEX 5
Methyl-HT-SELEX 1
PCM
ACGT
011944.03192.02469.02332.0
021310.251373.25949.256304.25
03161.0139.0266.09371.0
049769.00.0159.09.0
059933.03.00.01.0
068.00.09912.017.0
0721.018.015.09883.0
08899.06.09017.015.0
09173.02681.06556.0527.0
101094.03655.01472.03716.0
113554.02453.0896.03034.0
122511.05075.0872.01479.0
131623.03082.0979.04253.0
141894.251821.251190.255031.25
PFM
ACGT
010.1960.3210.2480.235
020.1320.1380.0960.634
030.0160.0140.0270.943
040.9830.00.0160.001
051.00.00.00.0
060.0010.00.9970.002
070.0020.0020.0020.995
080.090.0010.9070.002
090.0170.270.660.053
100.110.3680.1480.374
110.3580.2470.090.305
120.2530.5110.0880.149
130.1630.310.0990.428
140.1910.1830.120.506
PWM
ACGT
01-0.2450.25-0.006-0.063
02-0.639-0.592-0.9610.931
03-2.723-2.868-2.2271.327
041.369-6.985-2.735-5.394
051.385-6.151-6.985-6.624
06-5.486-6.9851.383-4.858
07-4.67-4.808-4.9681.38
08-1.015-5.7021.288-4.968
09-2.6520.0760.97-1.547
10-0.8190.386-0.5230.402
110.358-0.013-1.0180.2
120.0110.714-1.045-0.518
13-0.4250.215-0.930.537
14-0.271-0.31-0.7350.705
Standard thresholds
P-value Threshold
0.001 2.91571
0.0005 4.33296
0.0001 7.19646