MotifNKX25.H12INVITRO.0.PSM.A
Gene (human)NKX2-5
(GeneCards)
Gene synonyms (human)CSX, NKX2.5, NKX2E
Gene (mouse)Nkx2-5
Gene synonyms (mouse)Csx, Nkx-2.5, Nkx2e
LOGO
LOGO (reverse complement)
Motif subtype0
Quality
A
Motif length10
ConsensusbWYAAGTGSn
GC content46.49%
Information content (bits; total / per base)10.995 / 1.1
Data sourcesChIP-Seq + HT-SELEX + Methyl-HT-SELEX
Aligned words9953

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 2 (14) 0.754 0.763 0.6 0.618 0.706 0.716 1.802 1.86 90.651 104.215
Mouse 7 (29) 0.741 0.807 0.596 0.651 0.697 0.749 1.807 1.944 54.081 122.886

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 2 experiments median 0.983 0.971 0.961 0.946 0.883 0.87
best 0.992 0.985 0.985 0.977 0.917 0.91
Methyl HT-SELEX, 1 experiments median 0.992 0.985 0.985 0.977 0.917 0.91
best 0.992 0.985 0.985 0.977 0.917 0.91
Non-Methyl HT-SELEX, 1 experiments median 0.974 0.957 0.937 0.914 0.848 0.83
best 0.974 0.957 0.937 0.914 0.848 0.83
TF superclassHelix-turn-helix domains {3} (TFClass)
TF classHomeo domain factors {3.1} (TFClass)
TF familyNK-related {3.1.2} (TFClass)
TF subfamilyNK4 {3.1.2.17} (TFClass)
TFClass IDTFClass: 3.1.2.17.2
HGNCHGNC:2488
MGIMGI:97350
EntrezGene (human)GeneID:1482
(SSTAR profile)
EntrezGene (mouse)GeneID:18091
(SSTAR profile)
UniProt ID (human)NKX25_HUMAN
UniProt ID (mouse)NKX25_MOUSE
UniProt AC (human)P52952
(TFClass)
UniProt AC (mouse)P42582
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 2 human, 7 mouse
HT-SELEX 1
Methyl-HT-SELEX 1
PCM
ACGT
011331.753350.753286.751983.75
021575.51039.51159.56178.5
03280.03296.0859.05518.0
049673.00.0278.02.0
059953.00.00.00.0
060.00.09953.00.0
0781.01.017.09854.0
08595.04.09351.03.0
09302.03009.05521.01121.0
101932.52668.52477.52874.5
PFM
ACGT
010.1340.3370.330.199
020.1580.1040.1160.621
030.0280.3310.0860.554
040.9720.00.0280.0
051.00.00.00.0
060.00.01.00.0
070.0080.00.0020.99
080.060.00.940.0
090.030.3020.5550.113
100.1940.2680.2490.289
PWM
ACGT
01-0.6240.2970.278-0.226
02-0.456-0.872-0.7630.909
03-2.1770.281-1.0620.796
041.357-6.987-2.184-6.361
051.386-6.987-6.987-6.987
06-6.987-6.9871.386-6.987
07-3.398-6.626-4.861.376
08-1.428-5.9791.323-6.152
09-2.1020.190.796-0.796
10-0.2520.07-0.0040.144
Standard thresholds
P-value Threshold
0.001 4.345585
0.0005 5.67194
0.0001 7.72607