MotifNKX25.H12CORE.1.P.B
Gene (human)NKX2-5
(GeneCards)
Gene synonyms (human)CSX, NKX2.5, NKX2E
Gene (mouse)Nkx2-5
Gene synonyms (mouse)Csx, Nkx-2.5, Nkx2e
LOGO
LOGO (reverse complement)
Motif subtype1
Quality
B
Motif length13
ConsensusddSTGhTGASARv
GC content51.4%
Information content (bits; total / per base)10.787 / 0.83
Data sourcesChIP-Seq
Aligned words1002

ChIP-Seq benchmarking Num. of experiments (peaksets) auROC, median auROC, best auPRC, median auPRC, best pseudo-auROC, median pseudo-auROC, best pseudo-log-auROC, median pseudo-log-auROC, best Centrality, median Centrality, best
Human 2 (14) 0.844 0.855 0.746 0.766 0.806 0.812 2.724 2.777 109.008 124.77
Mouse 7 (29) 0.653 0.821 0.53 0.732 0.619 0.795 1.666 2.671 15.208 79.301

HT-SELEX benchmarking auROC10 auPRC10 auROC25 auPRC25 auROC50 auPRC50
Overall, 2 experiments median 0.529 0.515 0.53 0.516 0.526 0.514
best 0.545 0.524 0.541 0.522 0.533 0.519
Methyl HT-SELEX, 1 experiments median 0.513 0.507 0.518 0.509 0.518 0.509
best 0.513 0.507 0.518 0.509 0.518 0.509
Non-Methyl HT-SELEX, 1 experiments median 0.545 0.524 0.541 0.522 0.533 0.519
best 0.545 0.524 0.541 0.522 0.533 0.519
TF superclassHelix-turn-helix domains {3} (TFClass)
TF classHomeo domain factors {3.1} (TFClass)
TF familyNK-related {3.1.2} (TFClass)
TF subfamilyNK4 {3.1.2.17} (TFClass)
TFClass IDTFClass: 3.1.2.17.2
HGNCHGNC:2488
MGIMGI:97350
EntrezGene (human)GeneID:1482
(SSTAR profile)
EntrezGene (mouse)GeneID:18091
(SSTAR profile)
UniProt ID (human)NKX25_HUMAN
UniProt ID (mouse)NKX25_MOUSE
UniProt AC (human)P52952
(TFClass)
UniProt AC (mouse)P42582
(TFClass)
GRECO-DB-TF
yes
ChIP-Seq 2 human, 7 mouse
HT-SELEX 1
Methyl-HT-SELEX 1
PCM
ACGT
01444.098.0334.0126.0
02320.091.0439.0152.0
0385.0265.0584.068.0
0483.032.050.0837.0
0521.041.0933.07.0
06239.0333.0124.0306.0
0755.010.067.0870.0
0831.07.0963.01.0
09943.017.020.022.0
10173.0547.0252.030.0
11819.04.038.0141.0
12145.024.0730.0103.0
13195.0295.0398.0114.0
PFM
ACGT
010.4430.0980.3330.126
020.3190.0910.4380.152
030.0850.2640.5830.068
040.0830.0320.050.835
050.0210.0410.9310.007
060.2390.3320.1240.305
070.0550.010.0670.868
080.0310.0070.9610.001
090.9410.0170.020.022
100.1730.5460.2510.03
110.8170.0040.0380.141
120.1450.0240.7290.103
130.1950.2940.3970.114
PWM
ACGT
010.569-0.9280.286-0.68
020.243-1.0010.558-0.495
03-1.0680.0560.843-1.286
04-1.091-2.012-1.5841.202
05-2.407-1.7751.31-3.364
06-0.0470.283-0.6960.199
07-1.492-3.068-1.31.24
08-2.042-3.3641.342-4.527
091.321-2.6-2.452-2.364
10-0.3670.7770.006-2.073
111.18-3.785-1.848-0.569
12-0.542-2.2831.065-0.879
13-0.2490.1620.46-0.779
Standard thresholds
P-value Threshold
0.001 4.53411
0.0005 5.42071
0.0001 7.24336