NFE2.H12RSNP.0.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	NFE2.H12RSNP.0.P.B
Gene (human)	NFE2 (GeneCards)
Gene synonyms (human)
Gene (mouse)	Nfe2
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	13
Consensus	vnATGASTMWGCA
GC content	47.32%
Information content (bits; total / per base)	14.699 / 1.131
Data sources	ChIP-Seq
Aligned words	825

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	5 (34)	0.892	0.983	0.862	0.972	0.885	0.984	5.556	7.091	633.827	1052.0
Mouse	4 (26)	0.958	0.994	0.948	0.988	0.958	0.996	6.617	7.435	408.538	726.328

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.759	0.764	0.742	0.748	0.736	0.737
Overall, 4 experiments	best	0.994	0.989	0.991	0.985	0.983	0.975
Methyl HT-SELEX, 1 experiments	median	0.994	0.988	0.99	0.983	0.98	0.97
Methyl HT-SELEX, 1 experiments	best	0.994	0.988	0.99	0.983	0.98	0.97
Non-Methyl HT-SELEX, 3 experiments	median	0.524	0.539	0.495	0.513	0.492	0.504
Non-Methyl HT-SELEX, 3 experiments	best	0.994	0.989	0.991	0.985	0.983	0.975

rSNP benchmarking, ADASTRA	odds-ratio	-log-Fisher's P	Pearson r	Kendall tau
#	12.78	6.654	0.272	0.247

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 1	0.657	0.37	0.612	0.433
batch 2	0.765	0.208	0.653	0.345

TF superclass	Basic domains {1} (TFClass)
TF class	Basic leucine zipper factors (bZIP) {1.1} (TFClass)
TF family	Jun-related {1.1.1} (TFClass)
TF subfamily	NFE2 {1.1.1.2} (TFClass)
TFClass ID	TFClass: 1.1.1.2.1
HGNC	HGNC:7780
MGI	MGI:97308
EntrezGene (human)	GeneID:4778 (SSTAR profile)
EntrezGene (mouse)	GeneID:18022 (SSTAR profile)
UniProt ID (human)	NFE2_HUMAN
UniProt ID (mouse)	NFE2_MOUSE
UniProt AC (human)	Q16621 (TFClass)
UniProt AC (mouse)	Q07279 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	5 human, 4 mouse
HT-SELEX	3
Methyl-HT-SELEX	1

PCM	NFE2.H12RSNP.0.P.B.pcm
PWM	NFE2.H12RSNP.0.P.B.pwm
PFM	NFE2.H12RSNP.0.P.B.pfm
Alignment	NFE2.H12RSNP.0.P.B.words.tsv
Threshold to P-value map	NFE2.H12RSNP.0.P.B.thr
Motif in other formats
JASPAR format	NFE2.H12RSNP.0.P.B_jaspar_format.txt
MEME format	NFE2.H12RSNP.0.P.B_meme_format.meme
Transfac format	NFE2.H12RSNP.0.P.B_transfac_format.txt
Homer format	NFE2.H12RSNP.0.P.B_homer_format_0.001.txt NFE2.H12RSNP.0.P.B_homer_format_0.0005.txt NFE2.H12RSNP.0.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	196.0	208.0	309.0	112.0
02	271.0	203.0	239.0	112.0
03	604.0	25.0	195.0	1.0
04	2.0	0.0	1.0	822.0
05	0.0	2.0	814.0	9.0
06	822.0	1.0	1.0	1.0
07	15.0	643.0	119.0	48.0
08	134.0	7.0	19.0	665.0
09	108.0	573.0	47.0	97.0
10	628.0	6.0	89.0	102.0
11	34.0	5.0	709.0	77.0
12	6.0	791.0	17.0	11.0
13	673.0	19.0	33.0	100.0

PFM

	A	C	G	T
01	0.238	0.252	0.375	0.136
02	0.328	0.246	0.29	0.136
03	0.732	0.03	0.236	0.001
04	0.002	0.0	0.001	0.996
05	0.0	0.002	0.987	0.011
06	0.996	0.001	0.001	0.001
07	0.018	0.779	0.144	0.058
08	0.162	0.008	0.023	0.806
09	0.131	0.695	0.057	0.118
10	0.761	0.007	0.108	0.124
11	0.041	0.006	0.859	0.093
12	0.007	0.959	0.021	0.013
13	0.816	0.023	0.04	0.121

PWM

	A	C	G	T
01	-0.051	0.008	0.402	-0.604
02	0.271	-0.016	0.146	-0.604
03	1.069	-2.053	-0.056	-4.352
04	-4.035	-4.819	-4.352	1.377
05	-4.819	-4.035	1.367	-2.969
06	1.377	-4.352	-4.352	-4.352
07	-2.523	1.132	-0.544	-1.432
08	-0.427	-3.176	-2.308	1.165
09	-0.64	1.017	-1.452	-0.745
10	1.108	-3.299	-0.83	-0.696
11	-1.763	-3.438	1.229	-0.972
12	-3.299	1.338	-2.41	-2.797
13	1.177	-2.308	-1.791	-0.715

Standard thresholds

P-value	Threshold
0.001	2.92171
0.0005	4.15796
0.0001	6.67572