NFAT5.H12RSNP.1.PS.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	NFAT5.H12RSNP.1.PS.A
Gene (human)	NFAT5 (GeneCards)
Gene synonyms (human)	KIAA0827, TONEBP
Gene (mouse)	Nfat5
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	A

Motif length	18
Consensus	nnnRTGGAAAWTTMCdnn
GC content	40.0%
Information content (bits; total / per base)	18.264 / 1.015
Data sources	ChIP-Seq + HT-SELEX
Aligned words	9247

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Mouse	1 (5)	0.584	0.972	0.456	0.966	0.571	0.958	1.608	5.455	9.456	56.602

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.947	0.925	0.852	0.831	0.722	0.724
Overall, 4 experiments	best	1.0	1.0	0.999	0.999	0.876	0.897
Methyl HT-SELEX, 1 experiments	median	0.962	0.945	0.877	0.858	0.741	0.744
Methyl HT-SELEX, 1 experiments	best	0.962	0.945	0.877	0.858	0.741	0.744
Non-Methyl HT-SELEX, 3 experiments	median	0.931	0.904	0.827	0.803	0.702	0.703
Non-Methyl HT-SELEX, 3 experiments	best	1.0	1.0	0.999	0.999	0.876	0.897

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.731	0.472	0.682	0.471

TF superclass	Immunoglobulin fold {6} (TFClass)
TF class	Rel homology region (RHR) factors {6.1} (TFClass)
TF family	NFAT-related {6.1.3} (TFClass)
TF subfamily	{6.1.3.0} (TFClass)
TFClass ID	TFClass: 6.1.3.0.5
HGNC	HGNC:7774
MGI	MGI:1859333
EntrezGene (human)	GeneID:10725 (SSTAR profile)
EntrezGene (mouse)	GeneID:54446 (SSTAR profile)
UniProt ID (human)	NFAT5_HUMAN
UniProt ID (mouse)	NFAT5_MOUSE
UniProt AC (human)	O94916 (TFClass)
UniProt AC (mouse)	Q9WV30 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 1 mouse
HT-SELEX	3
Methyl-HT-SELEX	1

PCM	NFAT5.H12RSNP.1.PS.A.pcm
PWM	NFAT5.H12RSNP.1.PS.A.pwm
PFM	NFAT5.H12RSNP.1.PS.A.pfm
Alignment	NFAT5.H12RSNP.1.PS.A.words.tsv
Threshold to P-value map	NFAT5.H12RSNP.1.PS.A.thr
Motif in other formats
JASPAR format	NFAT5.H12RSNP.1.PS.A_jaspar_format.txt
MEME format	NFAT5.H12RSNP.1.PS.A_meme_format.meme
Transfac format	NFAT5.H12RSNP.1.PS.A_transfac_format.txt
Homer format	NFAT5.H12RSNP.1.PS.A_homer_format_0.001.txt NFAT5.H12RSNP.1.PS.A_homer_format_0.0005.txt NFAT5.H12RSNP.1.PS.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2210.0	2628.0	2624.0	1785.0
02	1496.5	2856.5	2838.5	2055.5
03	3530.0	2216.0	1642.0	1859.0
04	3301.0	412.0	5483.0	51.0
05	32.0	418.0	9.0	8788.0
06	1.0	0.0	9246.0	0.0
07	1.0	0.0	9142.0	104.0
08	9223.0	0.0	2.0	22.0
09	9231.0	6.0	9.0	1.0
10	8588.0	10.0	3.0	646.0
11	5806.0	45.0	530.0	2866.0
12	510.0	128.0	1152.0	7457.0
13	93.0	54.0	10.0	9090.0
14	4829.0	3542.0	10.0	866.0
15	89.0	8632.0	38.0	488.0
16	4047.0	1371.0	1447.0	2382.0
17	1685.0	1653.0	3390.0	2519.0
18	1533.5	2153.5	2877.5	2682.5

PFM

	A	C	G	T
01	0.239	0.284	0.284	0.193
02	0.162	0.309	0.307	0.222
03	0.382	0.24	0.178	0.201
04	0.357	0.045	0.593	0.006
05	0.003	0.045	0.001	0.95
06	0.0	0.0	1.0	0.0
07	0.0	0.0	0.989	0.011
08	0.997	0.0	0.0	0.002
09	0.998	0.001	0.001	0.0
10	0.929	0.001	0.0	0.07
11	0.628	0.005	0.057	0.31
12	0.055	0.014	0.125	0.806
13	0.01	0.006	0.001	0.983
14	0.522	0.383	0.001	0.094
15	0.01	0.933	0.004	0.053
16	0.438	0.148	0.156	0.258
17	0.182	0.179	0.367	0.272
18	0.166	0.233	0.311	0.29

PWM

	A	C	G	T
01	-0.045	0.128	0.127	-0.258
02	-0.434	0.211	0.205	-0.117
03	0.423	-0.042	-0.342	-0.218
04	0.356	-1.72	0.863	-3.771
05	-4.212	-1.706	-5.323	1.335
06	-6.558	-6.921	1.385	-6.921
07	-6.558	-6.921	1.374	-3.081
08	1.383	-6.921	-6.292	-4.557
09	1.384	-5.633	-5.323	-6.558
10	1.312	-5.239	-6.082	-1.272
11	0.92	-3.891	-1.47	0.215
12	-1.508	-2.877	-0.696	1.17
13	-3.19	-3.716	-5.239	1.368
14	0.736	0.426	-5.239	-0.98
15	-3.233	1.317	-4.051	-1.552
16	0.56	-0.522	-0.468	0.03
17	-0.316	-0.335	0.383	0.086
18	-0.41	-0.071	0.219	0.149

Standard thresholds

P-value	Threshold
0.001	-1.33949
0.0005	0.48336
0.0001	4.27031