NFAT5.H12RSNP.0.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	NFAT5.H12RSNP.0.SM.B
Gene (human)	NFAT5 (GeneCards)
Gene synonyms (human)	KIAA0827, TONEBP
Gene (mouse)	Nfat5
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	12
Consensus	nvYGGAAAdWYh
GC content	35.8%
Information content (bits; total / per base)	11.535 / 0.961
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	7305

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Mouse	1 (5)	0.577	0.962	0.43	0.941	0.585	0.943	1.471	4.041	8.337	56.796

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.942	0.912	0.871	0.84	0.737	0.736
Overall, 4 experiments	best	0.999	0.998	0.997	0.996	0.9	0.913
Methyl HT-SELEX, 1 experiments	median	0.952	0.926	0.892	0.862	0.753	0.753
Methyl HT-SELEX, 1 experiments	best	0.952	0.926	0.892	0.862	0.753	0.753
Non-Methyl HT-SELEX, 3 experiments	median	0.932	0.898	0.851	0.819	0.722	0.719
Non-Methyl HT-SELEX, 3 experiments	best	0.999	0.998	0.997	0.996	0.9	0.913

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.706	0.44	0.7	0.499

TF superclass	Immunoglobulin fold {6} (TFClass)
TF class	Rel homology region (RHR) factors {6.1} (TFClass)
TF family	NFAT-related {6.1.3} (TFClass)
TF subfamily	{6.1.3.0} (TFClass)
TFClass ID	TFClass: 6.1.3.0.5
HGNC	HGNC:7774
MGI	MGI:1859333
EntrezGene (human)	GeneID:10725 (SSTAR profile)
EntrezGene (mouse)	GeneID:54446 (SSTAR profile)
UniProt ID (human)	NFAT5_HUMAN
UniProt ID (mouse)	NFAT5_MOUSE
UniProt AC (human)	O94916 (TFClass)
UniProt AC (mouse)	Q9WV30 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 1 mouse
HT-SELEX	3
Methyl-HT-SELEX	1

PCM	NFAT5.H12RSNP.0.SM.B.pcm
PWM	NFAT5.H12RSNP.0.SM.B.pwm
PFM	NFAT5.H12RSNP.0.SM.B.pfm
Alignment	NFAT5.H12RSNP.0.SM.B.words.tsv
Threshold to P-value map	NFAT5.H12RSNP.0.SM.B.thr
Motif in other formats
JASPAR format	NFAT5.H12RSNP.0.SM.B_jaspar_format.txt
MEME format	NFAT5.H12RSNP.0.SM.B_meme_format.meme
Transfac format	NFAT5.H12RSNP.0.SM.B_transfac_format.txt
Homer format	NFAT5.H12RSNP.0.SM.B_homer_format_0.001.txt NFAT5.H12RSNP.0.SM.B_homer_format_0.0005.txt NFAT5.H12RSNP.0.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2441.5	1589.5	1627.5	1646.5
02	2826.25	786.25	3101.25	591.25
03	396.0	1173.0	281.0	5455.0
04	2.0	2.0	7299.0	2.0
05	0.0	0.0	7305.0	0.0
06	7280.0	0.0	25.0	0.0
07	7302.0	1.0	2.0	0.0
08	5781.0	69.0	483.0	972.0
09	3442.0	541.0	1406.0	1916.0
10	1132.0	643.0	985.0	4545.0
11	798.0	911.0	716.0	4880.0
12	2577.5	1643.5	796.5	2287.5

PFM

	A	C	G	T
01	0.334	0.218	0.223	0.225
02	0.387	0.108	0.425	0.081
03	0.054	0.161	0.038	0.747
04	0.0	0.0	0.999	0.0
05	0.0	0.0	1.0	0.0
06	0.997	0.0	0.003	0.0
07	1.0	0.0	0.0	0.0
08	0.791	0.009	0.066	0.133
09	0.471	0.074	0.192	0.262
10	0.155	0.088	0.135	0.622
11	0.109	0.125	0.098	0.668
12	0.353	0.225	0.109	0.313

PWM

	A	C	G	T
01	0.29	-0.139	-0.115	-0.103
02	0.436	-0.841	0.529	-1.125
03	-1.524	-0.442	-1.865	1.093
04	-6.07	-6.07	1.385	-6.07
05	-6.712	-6.712	1.385	-6.712
06	1.382	-6.712	-4.207	-6.712
07	1.385	-6.341	-6.07	-6.712
08	1.151	-3.245	-1.327	-0.63
09	0.633	-1.214	-0.261	0.048
10	-0.478	-1.042	-0.616	0.911
11	-0.826	-0.694	-0.934	0.982
12	0.344	-0.105	-0.828	0.225

Standard thresholds

P-value	Threshold
0.001	4.28856
0.0005	5.505515
0.0001	7.49862