NFAT5.H12INVIVO.1.PS.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	NFAT5.H12INVIVO.1.PS.A
Gene (human)	NFAT5 (GeneCards)
Gene synonyms (human)	KIAA0827, TONEBP
Gene (mouse)	Nfat5
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	A

Motif length	14
Consensus	ndvTGGAAAWWTMC
GC content	39.77%
Information content (bits; total / per base)	15.585 / 1.113
Data sources	ChIP-Seq + HT-SELEX
Aligned words	132

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Mouse	1 (5)	0.59	0.983	0.467	0.98	0.582	0.97	1.648	5.791	8.569	57.276

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.939	0.915	0.837	0.816	0.698	0.707
Overall, 4 experiments	best	1.0	1.0	0.999	0.999	0.89	0.907
Methyl HT-SELEX, 1 experiments	median	0.953	0.933	0.859	0.838	0.713	0.723
Methyl HT-SELEX, 1 experiments	best	0.953	0.933	0.859	0.838	0.713	0.723
Non-Methyl HT-SELEX, 3 experiments	median	0.926	0.897	0.816	0.794	0.684	0.691
Non-Methyl HT-SELEX, 3 experiments	best	1.0	1.0	0.999	0.999	0.89	0.907

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.679	0.42	0.688	0.475

TF superclass	Immunoglobulin fold {6} (TFClass)
TF class	Rel homology region (RHR) factors {6.1} (TFClass)
TF family	NFAT-related {6.1.3} (TFClass)
TF subfamily	{6.1.3.0} (TFClass)
TFClass ID	TFClass: 6.1.3.0.5
HGNC	HGNC:7774
MGI	MGI:1859333
EntrezGene (human)	GeneID:10725 (SSTAR profile)
EntrezGene (mouse)	GeneID:54446 (SSTAR profile)
UniProt ID (human)	NFAT5_HUMAN
UniProt ID (mouse)	NFAT5_MOUSE
UniProt AC (human)	O94916 (TFClass)
UniProt AC (mouse)	Q9WV30 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 1 mouse
HT-SELEX	3
Methyl-HT-SELEX	1

PCM	NFAT5.H12INVIVO.1.PS.A.pcm
PWM	NFAT5.H12INVIVO.1.PS.A.pwm
PFM	NFAT5.H12INVIVO.1.PS.A.pfm
Alignment	NFAT5.H12INVIVO.1.PS.A.words.tsv
Threshold to P-value map	NFAT5.H12INVIVO.1.PS.A.thr
Motif in other formats
JASPAR format	NFAT5.H12INVIVO.1.PS.A_jaspar_format.txt
MEME format	NFAT5.H12INVIVO.1.PS.A_meme_format.meme
Transfac format	NFAT5.H12INVIVO.1.PS.A_transfac_format.txt
Homer format	NFAT5.H12INVIVO.1.PS.A_homer_format_0.001.txt NFAT5.H12INVIVO.1.PS.A_homer_format_0.0005.txt NFAT5.H12INVIVO.1.PS.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	29.0	41.0	43.0	19.0
02	63.0	20.0	24.0	25.0
03	53.0	26.0	51.0	2.0
04	10.0	2.0	0.0	120.0
05	1.0	0.0	131.0	0.0
06	1.0	0.0	131.0	0.0
07	132.0	0.0	0.0	0.0
08	132.0	0.0	0.0	0.0
09	122.0	0.0	6.0	4.0
10	74.0	6.0	23.0	29.0
11	29.0	5.0	15.0	83.0
12	5.0	22.0	3.0	102.0
13	55.0	62.0	2.0	13.0
14	0.0	121.0	1.0	10.0

PFM

	A	C	G	T
01	0.22	0.311	0.326	0.144
02	0.477	0.152	0.182	0.189
03	0.402	0.197	0.386	0.015
04	0.076	0.015	0.0	0.909
05	0.008	0.0	0.992	0.0
06	0.008	0.0	0.992	0.0
07	1.0	0.0	0.0	0.0
08	1.0	0.0	0.0	0.0
09	0.924	0.0	0.045	0.03
10	0.561	0.045	0.174	0.22
11	0.22	0.038	0.114	0.629
12	0.038	0.167	0.023	0.773
13	0.417	0.47	0.015	0.098
14	0.0	0.917	0.008	0.076

PWM

	A	C	G	T
01	-0.124	0.21	0.256	-0.526
02	0.629	-0.478	-0.305	-0.266
03	0.46	-0.229	0.423	-2.363
04	-1.115	-2.363	-3.333	1.265
05	-2.735	-3.333	1.352	-3.333
06	-2.735	-3.333	1.352	-3.333
07	1.359	-3.333	-3.333	-3.333
08	1.359	-3.333	-3.333	-3.333
09	1.281	-3.333	-1.556	-1.88
10	0.788	-1.556	-0.346	-0.124
11	-0.124	-1.705	-0.747	0.901
12	-1.705	-0.388	-2.093	1.104
13	0.496	0.614	-2.363	-0.878
14	-3.333	1.273	-2.735	-1.115

Standard thresholds

P-value	Threshold
0.001	3.17391
0.0005	4.32126
0.0001	6.73046