NFAT5.H12INVIVO.0.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	NFAT5.H12INVIVO.0.SM.B
Gene (human)	NFAT5 (GeneCards)
Gene synonyms (human)	KIAA0827, TONEBP
Gene (mouse)	Nfat5
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	13
Consensus	nRYGGAAAddYhY
GC content	41.5%
Information content (bits; total / per base)	12.61 / 0.97
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	6656

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Mouse	1 (5)	0.581	0.969	0.451	0.948	0.592	0.959	1.582	4.839	4.796	52.886

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.954	0.934	0.884	0.86	0.749	0.75
Overall, 4 experiments	best	1.0	0.999	0.998	0.998	0.899	0.914
Methyl HT-SELEX, 1 experiments	median	0.974	0.962	0.914	0.895	0.77	0.776
Methyl HT-SELEX, 1 experiments	best	0.974	0.962	0.914	0.895	0.77	0.776
Non-Methyl HT-SELEX, 3 experiments	median	0.935	0.907	0.854	0.824	0.728	0.724
Non-Methyl HT-SELEX, 3 experiments	best	1.0	0.999	0.998	0.998	0.899	0.914

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.672	0.409	0.671	0.483

TF superclass	Immunoglobulin fold {6} (TFClass)
TF class	Rel homology region (RHR) factors {6.1} (TFClass)
TF family	NFAT-related {6.1.3} (TFClass)
TF subfamily	{6.1.3.0} (TFClass)
TFClass ID	TFClass: 6.1.3.0.5
HGNC	HGNC:7774
MGI	MGI:1859333
EntrezGene (human)	GeneID:10725 (SSTAR profile)
EntrezGene (mouse)	GeneID:54446 (SSTAR profile)
UniProt ID (human)	NFAT5_HUMAN
UniProt ID (mouse)	NFAT5_MOUSE
UniProt AC (human)	O94916 (TFClass)
UniProt AC (mouse)	Q9WV30 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 1 mouse
HT-SELEX	3
Methyl-HT-SELEX	1

PCM	NFAT5.H12INVIVO.0.SM.B.pcm
PWM	NFAT5.H12INVIVO.0.SM.B.pwm
PFM	NFAT5.H12INVIVO.0.SM.B.pfm
Alignment	NFAT5.H12INVIVO.0.SM.B.words.tsv
Threshold to P-value map	NFAT5.H12INVIVO.0.SM.B.thr
Motif in other formats
JASPAR format	NFAT5.H12INVIVO.0.SM.B_jaspar_format.txt
MEME format	NFAT5.H12INVIVO.0.SM.B_meme_format.meme
Transfac format	NFAT5.H12INVIVO.0.SM.B_transfac_format.txt
Homer format	NFAT5.H12INVIVO.0.SM.B_homer_format_0.001.txt NFAT5.H12INVIVO.0.SM.B_homer_format_0.0005.txt NFAT5.H12INVIVO.0.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2400.75	1600.75	1126.75	1527.75
02	4362.25	223.25	1806.25	264.25
03	107.0	3905.0	40.0	2604.0
04	0.0	0.0	6656.0	0.0
05	0.0	0.0	6656.0	0.0
06	6656.0	0.0	0.0	0.0
07	6656.0	0.0	0.0	0.0
08	5967.0	36.0	295.0	358.0
09	3124.0	664.0	1704.0	1164.0
10	1295.0	873.0	1495.0	2993.0
11	968.0	1198.0	515.0	3975.0
12	3373.0	1534.0	579.0	1170.0
13	753.0	4264.0	738.0	901.0

PFM

	A	C	G	T
01	0.361	0.24	0.169	0.23
02	0.655	0.034	0.271	0.04
03	0.016	0.587	0.006	0.391
04	0.0	0.0	1.0	0.0
05	0.0	0.0	1.0	0.0
06	1.0	0.0	0.0	0.0
07	1.0	0.0	0.0	0.0
08	0.896	0.005	0.044	0.054
09	0.469	0.1	0.256	0.175
10	0.195	0.131	0.225	0.45
11	0.145	0.18	0.077	0.597
12	0.507	0.23	0.087	0.176
13	0.113	0.641	0.111	0.135

PWM

	A	C	G	T
01	0.366	-0.039	-0.389	-0.085
02	0.963	-2.0	0.082	-1.833
03	-2.725	0.852	-3.676	0.447
04	-6.629	-6.629	1.385	-6.629
05	-6.629	-6.629	1.385	-6.629
06	1.385	-6.629	-6.629	-6.629
07	1.385	-6.629	-6.629	-6.629
08	1.276	-3.775	-1.724	-1.532
09	0.629	-0.917	0.024	-0.357
10	-0.25	-0.644	-0.107	0.586
11	-0.541	-0.328	-1.17	0.87
12	0.706	-0.081	-1.053	-0.352
13	-0.791	0.94	-0.811	-0.612

Standard thresholds

P-value	Threshold
0.001	3.28621
0.0005	4.84991
0.0001	7.43761