NFAT5.H12INVITRO.1.PS.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	NFAT5.H12INVITRO.1.PS.A
Gene (human)	NFAT5 (GeneCards)
Gene synonyms (human)	KIAA0827, TONEBP
Gene (mouse)	Nfat5
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	A

Motif length	14
Consensus	nRTGGAAAWKTMCn
GC content	34.25%
Information content (bits; total / per base)	17.242 / 1.232
Data sources	ChIP-Seq + HT-SELEX
Aligned words	9854

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Mouse	1 (5)	0.579	0.972	0.455	0.965	0.573	0.958	1.589	5.265	6.201	57.0

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.953	0.932	0.865	0.844	0.728	0.732
Overall, 4 experiments	best	1.0	1.0	0.999	0.999	0.897	0.913
Methyl HT-SELEX, 1 experiments	median	0.967	0.95	0.89	0.871	0.748	0.753
Methyl HT-SELEX, 1 experiments	best	0.967	0.95	0.89	0.871	0.748	0.753
Non-Methyl HT-SELEX, 3 experiments	median	0.94	0.914	0.84	0.817	0.707	0.711
Non-Methyl HT-SELEX, 3 experiments	best	1.0	1.0	0.999	0.999	0.897	0.913

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.692	0.438	0.695	0.487

TF superclass	Immunoglobulin fold {6} (TFClass)
TF class	Rel homology region (RHR) factors {6.1} (TFClass)
TF family	NFAT-related {6.1.3} (TFClass)
TF subfamily	{6.1.3.0} (TFClass)
TFClass ID	TFClass: 6.1.3.0.5
HGNC	HGNC:7774
MGI	MGI:1859333
EntrezGene (human)	GeneID:10725 (SSTAR profile)
EntrezGene (mouse)	GeneID:54446 (SSTAR profile)
UniProt ID (human)	NFAT5_HUMAN
UniProt ID (mouse)	NFAT5_MOUSE
UniProt AC (human)	O94916 (TFClass)
UniProt AC (mouse)	Q9WV30 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 1 mouse
HT-SELEX	3
Methyl-HT-SELEX	1

PCM	NFAT5.H12INVITRO.1.PS.A.pcm
PWM	NFAT5.H12INVITRO.1.PS.A.pwm
PFM	NFAT5.H12INVITRO.1.PS.A.pfm
Alignment	NFAT5.H12INVITRO.1.PS.A.words.tsv
Threshold to P-value map	NFAT5.H12INVITRO.1.PS.A.thr
Motif in other formats
JASPAR format	NFAT5.H12INVITRO.1.PS.A_jaspar_format.txt
MEME format	NFAT5.H12INVITRO.1.PS.A_meme_format.meme
Transfac format	NFAT5.H12INVITRO.1.PS.A_transfac_format.txt
Homer format	NFAT5.H12INVITRO.1.PS.A_homer_format_0.001.txt NFAT5.H12INVITRO.1.PS.A_homer_format_0.0005.txt NFAT5.H12INVITRO.1.PS.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	3708.25	2254.25	1773.25	2118.25
02	4097.25	509.25	5200.25	47.25
03	20.0	572.0	2.0	9260.0
04	0.0	2.0	9851.0	1.0
05	0.0	1.0	9850.0	3.0
06	9833.0	1.0	17.0	3.0
07	9843.0	2.0	6.0	3.0
08	9519.0	5.0	11.0	319.0
09	6306.0	76.0	960.0	2512.0
10	795.0	224.0	989.0	7846.0
11	130.0	117.0	17.0	9590.0
12	4541.0	2903.0	19.0	2391.0
13	298.75	8000.75	268.75	1285.75
14	3484.5	1782.5	1835.5	2751.5

PFM

	A	C	G	T
01	0.376	0.229	0.18	0.215
02	0.416	0.052	0.528	0.005
03	0.002	0.058	0.0	0.94
04	0.0	0.0	1.0	0.0
05	0.0	0.0	1.0	0.0
06	0.998	0.0	0.002	0.0
07	0.999	0.0	0.001	0.0
08	0.966	0.001	0.001	0.032
09	0.64	0.008	0.097	0.255
10	0.081	0.023	0.1	0.796
11	0.013	0.012	0.002	0.973
12	0.461	0.295	0.002	0.243
13	0.03	0.812	0.027	0.13
14	0.354	0.181	0.186	0.279

PWM

	A	C	G	T
01	0.409	-0.089	-0.328	-0.151
02	0.508	-1.573	0.747	-3.907
03	-4.706	-1.457	-6.352	1.323
04	-6.978	-6.352	1.385	-6.617
05	-6.978	-6.617	1.385	-6.143
06	1.383	-6.617	-4.85	-6.143
07	1.384	-6.352	-5.694	-6.143
08	1.351	-5.823	-5.223	-2.038
09	0.939	-3.45	-0.941	0.019
10	-1.129	-2.388	-0.911	1.158
11	-2.925	-3.029	-4.85	1.358
12	0.611	0.164	-4.752	-0.03
13	-2.103	1.177	-2.208	-0.649
14	0.346	-0.323	-0.294	0.11

Standard thresholds

P-value	Threshold
0.001	-0.75034
0.0005	1.07501
0.0001	4.809015