NFAT5.H12INVITRO.0.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	NFAT5.H12INVITRO.0.SM.B
Gene (human)	NFAT5 (GeneCards)
Gene synonyms (human)	KIAA0827, TONEBP
Gene (mouse)	Nfat5
Gene synonyms (mouse)
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	13
Consensus	nRYGGAARddhhb
GC content	43.75%
Information content (bits; total / per base)	10.554 / 0.812
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	9929

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Mouse	1 (5)	0.578	0.967	0.452	0.946	0.595	0.958	1.583	4.802	4.155	52.387

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.955	0.935	0.886	0.862	0.754	0.753
Overall, 4 experiments	best	1.0	0.999	0.998	0.998	0.901	0.915
Methyl HT-SELEX, 1 experiments	median	0.974	0.962	0.916	0.897	0.775	0.779
Methyl HT-SELEX, 1 experiments	best	0.974	0.962	0.916	0.897	0.775	0.779
Non-Methyl HT-SELEX, 3 experiments	median	0.937	0.909	0.857	0.827	0.733	0.727
Non-Methyl HT-SELEX, 3 experiments	best	1.0	0.999	0.998	0.998	0.901	0.915

rSNP benchmarking, SNP-SELEX	auROC	auPRC	Pearson r	Kendall tau
batch 2	0.678	0.396	0.669	0.486

TF superclass	Immunoglobulin fold {6} (TFClass)
TF class	Rel homology region (RHR) factors {6.1} (TFClass)
TF family	NFAT-related {6.1.3} (TFClass)
TF subfamily	{6.1.3.0} (TFClass)
TFClass ID	TFClass: 6.1.3.0.5
HGNC	HGNC:7774
MGI	MGI:1859333
EntrezGene (human)	GeneID:10725 (SSTAR profile)
EntrezGene (mouse)	GeneID:54446 (SSTAR profile)
UniProt ID (human)	NFAT5_HUMAN
UniProt ID (mouse)	NFAT5_MOUSE
UniProt AC (human)	O94916 (TFClass)
UniProt AC (mouse)	Q9WV30 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	0 human, 1 mouse
HT-SELEX	3
Methyl-HT-SELEX	1

PCM	NFAT5.H12INVITRO.0.SM.B.pcm
PWM	NFAT5.H12INVITRO.0.SM.B.pwm
PFM	NFAT5.H12INVITRO.0.SM.B.pfm
Alignment	NFAT5.H12INVITRO.0.SM.B.words.tsv
Threshold to P-value map	NFAT5.H12INVITRO.0.SM.B.thr
Motif in other formats
JASPAR format	NFAT5.H12INVITRO.0.SM.B_jaspar_format.txt
MEME format	NFAT5.H12INVITRO.0.SM.B_meme_format.meme
Transfac format	NFAT5.H12INVITRO.0.SM.B_transfac_format.txt
Homer format	NFAT5.H12INVITRO.0.SM.B_homer_format_0.001.txt NFAT5.H12INVITRO.0.SM.B_homer_format_0.0005.txt NFAT5.H12INVITRO.0.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	3396.75	2396.75	1866.75	2268.75
02	5769.5	527.5	2906.5	725.5
03	477.0	5248.0	300.0	3904.0
04	0.0	3.0	9925.0	1.0
05	1.0	6.0	9916.0	6.0
06	9895.0	5.0	11.0	18.0
07	9729.0	9.0	148.0	43.0
08	7184.0	304.0	1277.0	1164.0
09	3933.0	1197.0	2825.0	1974.0
10	2074.0	1530.0	2316.0	4009.0
11	1764.0	1976.0	1206.0	4983.0
12	4130.75	2379.75	1362.75	2055.75
13	1423.25	5321.25	1514.25	1670.25

PFM

	A	C	G	T
01	0.342	0.241	0.188	0.228
02	0.581	0.053	0.293	0.073
03	0.048	0.529	0.03	0.393
04	0.0	0.0	1.0	0.0
05	0.0	0.001	0.999	0.001
06	0.997	0.001	0.001	0.002
07	0.98	0.001	0.015	0.004
08	0.724	0.031	0.129	0.117
09	0.396	0.121	0.285	0.199
10	0.209	0.154	0.233	0.404
11	0.178	0.199	0.121	0.502
12	0.416	0.24	0.137	0.207
13	0.143	0.536	0.153	0.168

PWM

	A	C	G	T
01	0.313	-0.035	-0.285	-0.09
02	0.843	-1.545	0.158	-1.228
03	-1.646	0.748	-2.106	0.452
04	-6.985	-6.15	1.385	-6.624
05	-6.624	-5.701	1.384	-5.701
06	1.382	-5.83	-5.23	-4.807
07	1.365	-5.393	-2.805	-4.005
08	1.062	-2.093	-0.664	-0.756
09	0.46	-0.728	0.129	-0.229
10	-0.18	-0.483	-0.069	0.479
11	-0.341	-0.228	-0.721	0.696
12	0.509	-0.042	-0.599	-0.188
13	-0.556	0.762	-0.494	-0.396

Standard thresholds

P-value	Threshold
0.001	4.77431
0.0005	5.82216
0.0001	7.562715