NFAC4.H12INVIVO.1.SM.D motif - HOmo sapiens COmprehensive MOdel COllection

Motif	NFAC4.H12INVIVO.1.SM.D
Gene (human)	NFATC4 (GeneCards)
Gene synonyms (human)	NFAT3
Gene (mouse)	Nfatc4
Gene synonyms (mouse)	Nfat3
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	D

Motif length	12
Consensus	nhACGGAAAvdn
GC content	40.46%
Information content (bits; total / per base)	12.444 / 1.037
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	9555

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	1 (4)	0.527	0.53	0.343	0.35	0.539	0.546	1.11	1.136	0.0	0

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.984	0.972	0.978	0.964	0.963	0.946
Overall, 4 experiments	best	0.995	0.991	0.991	0.985	0.985	0.977
Methyl HT-SELEX, 2 experiments	median	0.985	0.974	0.978	0.965	0.963	0.946
Methyl HT-SELEX, 2 experiments	best	0.995	0.991	0.991	0.985	0.982	0.973
Non-Methyl HT-SELEX, 2 experiments	median	0.965	0.942	0.95	0.924	0.907	0.886
Non-Methyl HT-SELEX, 2 experiments	best	0.993	0.988	0.991	0.984	0.985	0.977

TF superclass	Immunoglobulin fold {6} (TFClass)
TF class	Rel homology region (RHR) factors {6.1} (TFClass)
TF family	NFAT-related {6.1.3} (TFClass)
TF subfamily	{6.1.3.0} (TFClass)
TFClass ID	TFClass: 6.1.3.0.4
HGNC	HGNC:7778
MGI	MGI:1920431
EntrezGene (human)	GeneID:4776 (SSTAR profile)
EntrezGene (mouse)	GeneID:73181 (SSTAR profile)
UniProt ID (human)	NFAC4_HUMAN
UniProt ID (mouse)	NFAC4_MOUSE
UniProt AC (human)	Q14934 (TFClass)
UniProt AC (mouse)	Q8K120 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	1 human, 0 mouse
HT-SELEX	2
Methyl-HT-SELEX	2

PCM	NFAC4.H12INVIVO.1.SM.D.pcm
PWM	NFAC4.H12INVIVO.1.SM.D.pwm
PFM	NFAC4.H12INVIVO.1.SM.D.pfm
Alignment	NFAC4.H12INVIVO.1.SM.D.words.tsv
Threshold to P-value map	NFAC4.H12INVIVO.1.SM.D.thr
Motif in other formats
JASPAR format	NFAC4.H12INVIVO.1.SM.D_jaspar_format.txt
MEME format	NFAC4.H12INVIVO.1.SM.D_meme_format.meme
Transfac format	NFAC4.H12INVIVO.1.SM.D_transfac_format.txt
Homer format	NFAC4.H12INVIVO.1.SM.D_homer_format_0.001.txt NFAC4.H12INVIVO.1.SM.D_homer_format_0.0005.txt NFAC4.H12INVIVO.1.SM.D_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1966.75	2532.75	2582.75	2472.75
02	3973.75	2207.75	1211.75	2161.75
03	7206.0	99.0	1997.0	253.0
04	1.0	5993.0	0.0	3561.0
05	0.0	0.0	9555.0	0.0
06	0.0	0.0	9555.0	0.0
07	9555.0	0.0	0.0	0.0
08	9555.0	0.0	0.0	0.0
09	9253.0	218.0	2.0	82.0
10	3565.0	3194.0	1579.0	1217.0
11	3505.25	851.25	952.25	4246.25
12	2415.5	1613.5	2248.5	3277.5

PFM

	A	C	G	T
01	0.206	0.265	0.27	0.259
02	0.416	0.231	0.127	0.226
03	0.754	0.01	0.209	0.026
04	0.0	0.627	0.0	0.373
05	0.0	0.0	1.0	0.0
06	0.0	0.0	1.0	0.0
07	1.0	0.0	0.0	0.0
08	1.0	0.0	0.0	0.0
09	0.968	0.023	0.0	0.009
10	0.373	0.334	0.165	0.127
11	0.367	0.089	0.1	0.444
12	0.253	0.169	0.235	0.343

PWM

	A	C	G	T
01	-0.194	0.058	0.078	0.035
02	0.509	-0.079	-0.678	-0.1
03	1.104	-3.161	-0.179	-2.237
04	-6.588	0.919	-6.95	0.399
05	-6.95	-6.95	1.386	-6.95
06	-6.95	-6.95	1.386	-6.95
07	1.386	-6.95	-6.95	-6.95
08	1.386	-6.95	-6.95	-6.95
09	1.353	-2.385	-6.323	-3.345
10	0.4	0.29	-0.413	-0.673
11	0.383	-1.03	-0.918	0.575
12	0.011	-0.392	-0.06	0.316

Standard thresholds

P-value	Threshold
0.001	1.90392
0.0005	4.238375
0.0001	7.844875