NFAC3.H12CORE.0.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	NFAC3.H12CORE.0.SM.B
Gene (human)	NFATC3 (GeneCards)
Gene synonyms (human)	NFAT4
Gene (mouse)	Nfatc3
Gene synonyms (mouse)	Nfat4
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	14
Consensus	nbnRCGGAAAvWnn
GC content	42.27%
Information content (bits; total / per base)	13.0 / 0.929
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	9710

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	1 (6)	0.607	0.64	0.476	0.514	0.572	0.586	1.501	1.598	15.131	20.432

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 2 experiments	median	0.994	0.99	0.992	0.986	0.985	0.977
Overall, 2 experiments	best	0.997	0.994	0.995	0.992	0.991	0.986
Methyl HT-SELEX, 1 experiments	median	0.997	0.994	0.995	0.992	0.991	0.986
Methyl HT-SELEX, 1 experiments	best	0.997	0.994	0.995	0.992	0.991	0.986
Non-Methyl HT-SELEX, 1 experiments	median	0.992	0.985	0.988	0.98	0.98	0.969
Non-Methyl HT-SELEX, 1 experiments	best	0.992	0.985	0.988	0.98	0.98	0.969

TF superclass	Immunoglobulin fold {6} (TFClass)
TF class	Rel homology region (RHR) factors {6.1} (TFClass)
TF family	NFAT-related {6.1.3} (TFClass)
TF subfamily	{6.1.3.0} (TFClass)
TFClass ID	TFClass: 6.1.3.0.3
HGNC	HGNC:7777
MGI	MGI:103296
EntrezGene (human)	GeneID:4775 (SSTAR profile)
EntrezGene (mouse)
UniProt ID (human)	NFAC3_HUMAN
UniProt ID (mouse)	NFAC3_MOUSE
UniProt AC (human)	Q12968 (TFClass)
UniProt AC (mouse)	P97305 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	1 human, 0 mouse
HT-SELEX	1
Methyl-HT-SELEX	1

PCM	NFAC3.H12CORE.0.SM.B.pcm
PWM	NFAC3.H12CORE.0.SM.B.pwm
PFM	NFAC3.H12CORE.0.SM.B.pfm
Alignment	NFAC3.H12CORE.0.SM.B.words.tsv
Threshold to P-value map	NFAC3.H12CORE.0.SM.B.thr
Motif in other formats
JASPAR format	NFAC3.H12CORE.0.SM.B_jaspar_format.txt
MEME format	NFAC3.H12CORE.0.SM.B_meme_format.meme
Transfac format	NFAC3.H12CORE.0.SM.B_transfac_format.txt
Homer format	NFAC3.H12CORE.0.SM.B_homer_format_0.001.txt NFAC3.H12CORE.0.SM.B_homer_format_0.0005.txt NFAC3.H12CORE.0.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1812.5	2332.5	3085.5	2479.5
02	1246.75	3077.75	3302.75	2082.75
03	3523.0	2006.0	1625.0	2556.0
04	6593.0	30.0	2919.0	168.0
05	0.0	5723.0	0.0	3987.0
06	0.0	0.0	9710.0	0.0
07	0.0	0.0	9710.0	0.0
08	9710.0	0.0	0.0	0.0
09	9710.0	0.0	0.0	0.0
10	9689.0	18.0	0.0	3.0
11	4058.0	3238.0	1583.0	831.0
12	3587.0	524.0	442.0	5157.0
13	3025.5	1277.5	2253.5	3153.5
14	2229.75	2415.75	2194.75	2869.75

PFM

	A	C	G	T
01	0.187	0.24	0.318	0.255
02	0.128	0.317	0.34	0.214
03	0.363	0.207	0.167	0.263
04	0.679	0.003	0.301	0.017
05	0.0	0.589	0.0	0.411
06	0.0	0.0	1.0	0.0
07	0.0	0.0	1.0	0.0
08	1.0	0.0	0.0	0.0
09	1.0	0.0	0.0	0.0
10	0.998	0.002	0.0	0.0
11	0.418	0.333	0.163	0.086
12	0.369	0.054	0.046	0.531
13	0.312	0.132	0.232	0.325
14	0.23	0.249	0.226	0.296

PWM

	A	C	G	T
01	-0.292	-0.04	0.24	0.021
02	-0.665	0.237	0.308	-0.153
03	0.372	-0.191	-0.401	0.052
04	0.999	-4.321	0.184	-2.658
05	-6.965	0.857	-6.965	0.496
06	-6.965	-6.965	1.386	-6.965
07	-6.965	-6.965	1.386	-6.965
08	1.386	-6.965	-6.965	-6.965
09	1.386	-6.965	-6.965	-6.965
10	1.383	-4.785	-6.965	-6.129
11	0.513	0.288	-0.427	-1.07
12	0.39	-1.53	-1.699	0.753
13	0.22	-0.641	-0.074	0.261
14	-0.085	-0.005	-0.101	0.167

Standard thresholds

P-value	Threshold
0.001	0.99611
0.0005	2.30351
0.0001	7.69401