NFAC2.H12INVIVO.4.M.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	NFAC2.H12INVIVO.4.M.B
Gene (human)	NFATC2 (GeneCards)
Gene synonyms (human)	NFAT1, NFATP
Gene (mouse)	Nfatc2
Gene synonyms (mouse)	Nfat1, Nfatp
LOGO
LOGO (reverse complement)
Motif subtype	4
Quality	B

Motif length	19
Consensus	dKWYYvnbhACGGAAAhWn
GC content	39.77%
Information content (bits; total / per base)	16.525 / 0.87
Data sources	Methyl-HT-SELEX
Aligned words	2149

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	2 (10)	0.739	0.764	0.594	0.628	0.703	0.722	1.928	2.08	42.533	89.886
Mouse	1 (7)	0.795	0.808	0.647	0.657	0.731	0.736	1.979	2.021	75.409	85.824

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.992	0.988	0.98	0.971	0.94	0.927
Overall, 4 experiments	best	1.0	1.0	0.999	0.999	0.986	0.985
Methyl HT-SELEX, 2 experiments	median	0.986	0.98	0.972	0.96	0.935	0.922
Methyl HT-SELEX, 2 experiments	best	1.0	1.0	0.999	0.999	0.986	0.985
Non-Methyl HT-SELEX, 2 experiments	median	0.992	0.988	0.98	0.971	0.94	0.927
Non-Methyl HT-SELEX, 2 experiments	best	0.999	0.998	0.988	0.985	0.949	0.941

TF superclass	Immunoglobulin fold {6} (TFClass)
TF class	Rel homology region (RHR) factors {6.1} (TFClass)
TF family	NFAT-related {6.1.3} (TFClass)
TF subfamily	{6.1.3.0} (TFClass)
TFClass ID	TFClass: 6.1.3.0.2
HGNC	HGNC:7776
MGI	MGI:102463
EntrezGene (human)	GeneID:4773 (SSTAR profile)
EntrezGene (mouse)	GeneID:18019 (SSTAR profile)
UniProt ID (human)	NFAC2_HUMAN
UniProt ID (mouse)	NFAC2_MOUSE
UniProt AC (human)	Q13469 (TFClass)
UniProt AC (mouse)	Q60591 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	2 human, 1 mouse
HT-SELEX	2
Methyl-HT-SELEX	2

PCM	NFAC2.H12INVIVO.4.M.B.pcm
PWM	NFAC2.H12INVIVO.4.M.B.pwm
PFM	NFAC2.H12INVIVO.4.M.B.pfm
Alignment	NFAC2.H12INVIVO.4.M.B.words.tsv
Threshold to P-value map	NFAC2.H12INVIVO.4.M.B.thr
Motif in other formats
JASPAR format	NFAC2.H12INVIVO.4.M.B_jaspar_format.txt
MEME format	NFAC2.H12INVIVO.4.M.B_meme_format.meme
Transfac format	NFAC2.H12INVIVO.4.M.B_transfac_format.txt
Homer format	NFAC2.H12INVIVO.4.M.B_homer_format_0.001.txt NFAC2.H12INVIVO.4.M.B_homer_format_0.0005.txt NFAC2.H12INVIVO.4.M.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	377.25	351.25	394.25	1026.25
02	235.5	202.5	303.5	1407.5
03	205.0	119.0	140.0	1685.0
04	175.0	764.0	112.0	1098.0
05	163.0	1578.0	97.0	311.0
06	340.0	1012.0	509.0	288.0
07	440.0	409.0	724.0	576.0
08	281.0	574.0	321.0	973.0
09	1071.0	306.0	104.0	668.0
10	1669.0	4.0	429.0	47.0
11	0.0	1677.0	0.0	472.0
12	0.0	0.0	2149.0	0.0
13	0.0	0.0	2149.0	0.0
14	2149.0	0.0	0.0	0.0
15	2149.0	0.0	0.0	0.0
16	2060.0	67.0	2.0	20.0
17	1054.0	495.0	266.0	334.0
18	706.5	123.5	119.5	1199.5
19	667.25	388.25	349.25	744.25

PFM

	A	C	G	T
01	0.176	0.163	0.183	0.478
02	0.11	0.094	0.141	0.655
03	0.095	0.055	0.065	0.784
04	0.081	0.356	0.052	0.511
05	0.076	0.734	0.045	0.145
06	0.158	0.471	0.237	0.134
07	0.205	0.19	0.337	0.268
08	0.131	0.267	0.149	0.453
09	0.498	0.142	0.048	0.311
10	0.777	0.002	0.2	0.022
11	0.0	0.78	0.0	0.22
12	0.0	0.0	1.0	0.0
13	0.0	0.0	1.0	0.0
14	1.0	0.0	0.0	0.0
15	1.0	0.0	0.0	0.0
16	0.959	0.031	0.001	0.009
17	0.49	0.23	0.124	0.155
18	0.329	0.057	0.056	0.558
19	0.31	0.181	0.163	0.346

PWM

	A	C	G	T
01	-0.352	-0.423	-0.308	0.646
02	-0.82	-0.97	-0.568	0.961
03	-0.958	-1.495	-1.335	1.141
04	-1.114	0.351	-1.555	0.713
05	-1.185	1.075	-1.696	-0.544
06	-0.455	0.632	-0.054	-0.62
07	-0.199	-0.272	0.297	0.069
08	-0.645	0.066	-0.513	0.592
09	0.688	-0.56	-1.627	0.217
10	1.131	-4.512	-0.224	-2.4
11	-5.639	1.136	-5.639	-0.129
12	-5.639	-5.639	1.384	-5.639
13	-5.639	-5.639	1.384	-5.639
14	1.384	-5.639	-5.639	-5.639
15	1.384	-5.639	-5.639	-5.639
16	1.341	-2.057	-4.924	-3.203
17	0.672	-0.082	-0.699	-0.473
18	0.273	-1.458	-1.491	0.801
19	0.216	-0.323	-0.429	0.325

Standard thresholds

P-value	Threshold
0.001	0.97626
0.0005	2.56161
0.0001	5.90161