NFAC2.H12INVIVO.3.M.C motif - HOmo sapiens COmprehensive MOdel COllection

Motif	NFAC2.H12INVIVO.3.M.C
Gene (human)	NFATC2 (GeneCards)
Gene synonyms (human)	NFAT1, NFATP
Gene (mouse)	Nfatc2
Gene synonyms (mouse)	Nfat1, Nfatp
LOGO
LOGO (reverse complement)
Motif subtype	3
Quality	C

Motif length	11
Consensus	nhACGGAAAvn
GC content	44.94%
Information content (bits; total / per base)	11.718 / 1.065
Data sources	Methyl-HT-SELEX
Aligned words	1801

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	2 (10)	0.736	0.768	0.552	0.63	0.74	0.763	2.135	2.234	74.634	136.745
Mouse	1 (7)	0.802	0.814	0.672	0.685	0.768	0.774	2.101	2.134	118.481	126.119

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.981	0.966	0.975	0.957	0.96	0.94
Overall, 4 experiments	best	0.996	0.994	0.993	0.989	0.982	0.976
Methyl HT-SELEX, 2 experiments	median	0.975	0.957	0.967	0.947	0.948	0.925
Methyl HT-SELEX, 2 experiments	best	0.996	0.994	0.993	0.989	0.982	0.976
Non-Methyl HT-SELEX, 2 experiments	median	0.981	0.966	0.975	0.957	0.96	0.94
Non-Methyl HT-SELEX, 2 experiments	best	0.99	0.983	0.987	0.978	0.98	0.969

TF superclass	Immunoglobulin fold {6} (TFClass)
TF class	Rel homology region (RHR) factors {6.1} (TFClass)
TF family	NFAT-related {6.1.3} (TFClass)
TF subfamily	{6.1.3.0} (TFClass)
TFClass ID	TFClass: 6.1.3.0.2
HGNC	HGNC:7776
MGI	MGI:102463
EntrezGene (human)	GeneID:4773 (SSTAR profile)
EntrezGene (mouse)	GeneID:18019 (SSTAR profile)
UniProt ID (human)	NFAC2_HUMAN
UniProt ID (mouse)	NFAC2_MOUSE
UniProt AC (human)	Q13469 (TFClass)
UniProt AC (mouse)	Q60591 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	2 human, 1 mouse
HT-SELEX	2
Methyl-HT-SELEX	2

PCM	NFAC2.H12INVIVO.3.M.C.pcm
PWM	NFAC2.H12INVIVO.3.M.C.pwm
PFM	NFAC2.H12INVIVO.3.M.C.pfm
Alignment	NFAC2.H12INVIVO.3.M.C.words.tsv
Threshold to P-value map	NFAC2.H12INVIVO.3.M.C.thr
Motif in other formats
JASPAR format	NFAC2.H12INVIVO.3.M.C_jaspar_format.txt
MEME format	NFAC2.H12INVIVO.3.M.C_meme_format.meme
Transfac format	NFAC2.H12INVIVO.3.M.C_transfac_format.txt
Homer format	NFAC2.H12INVIVO.3.M.C_homer_format_0.001.txt NFAC2.H12INVIVO.3.M.C_homer_format_0.0005.txt NFAC2.H12INVIVO.3.M.C_homer_format_0.0001.txt

PCM

	A	C	G	T
01	344.75	568.75	433.75	453.75
02	751.5	484.5	124.5	440.5
03	1320.0	14.0	457.0	10.0
04	0.0	1236.0	0.0	565.0
05	0.0	0.0	1801.0	0.0
06	0.0	0.0	1801.0	0.0
07	1801.0	0.0	0.0	0.0
08	1801.0	0.0	0.0	0.0
09	1490.0	216.0	2.0	93.0
10	543.75	452.75	603.75	200.75
11	447.0	344.0	365.0	645.0

PFM

	A	C	G	T
01	0.191	0.316	0.241	0.252
02	0.417	0.269	0.069	0.245
03	0.733	0.008	0.254	0.006
04	0.0	0.686	0.0	0.314
05	0.0	0.0	1.0	0.0
06	0.0	0.0	1.0	0.0
07	1.0	0.0	0.0	0.0
08	1.0	0.0	0.0	0.0
09	0.827	0.12	0.001	0.052
10	0.302	0.251	0.335	0.111
11	0.248	0.191	0.203	0.358

PWM

	A	C	G	T
01	-0.266	0.233	-0.037	0.008
02	0.511	0.073	-1.275	-0.022
03	1.073	-3.349	0.015	-3.64
04	-5.486	1.007	-5.486	0.226
05	-5.486	-5.486	1.383	-5.486
06	-5.486	-5.486	1.383	-5.486
07	1.383	-5.486	-5.486	-5.486
08	1.383	-5.486	-5.486	-5.486
09	1.194	-0.73	-4.76	-1.561
10	0.188	0.006	0.292	-0.803
11	-0.007	-0.268	-0.209	0.358

Standard thresholds

P-value	Threshold
0.001	2.886325
0.0005	5.215535
0.0001	7.9101