NFAC2.H12INVIVO.1.PS.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	NFAC2.H12INVIVO.1.PS.A
Gene (human)	NFATC2 (GeneCards)
Gene synonyms (human)	NFAT1, NFATP
Gene (mouse)	Nfatc2
Gene synonyms (mouse)	Nfat1, Nfatp
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	A

Motif length	12
Consensus	vvvvWGGAAWvd
GC content	43.06%
Information content (bits; total / per base)	8.436 / 0.703
Data sources	ChIP-Seq + HT-SELEX
Aligned words	1008

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	2 (10)	0.743	0.783	0.54	0.63	0.802	0.823	2.658	2.845	90.941	167.523
Mouse	1 (7)	0.823	0.831	0.669	0.68	0.819	0.824	2.492	2.528	113.921	122.921

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.967	0.947	0.949	0.923	0.917	0.886
Overall, 4 experiments	best	0.993	0.987	0.99	0.982	0.98	0.97
Methyl HT-SELEX, 2 experiments	median	0.954	0.925	0.935	0.902	0.895	0.861
Methyl HT-SELEX, 2 experiments	best	0.984	0.972	0.974	0.958	0.944	0.924
Non-Methyl HT-SELEX, 2 experiments	median	0.972	0.954	0.957	0.935	0.935	0.909
Non-Methyl HT-SELEX, 2 experiments	best	0.993	0.987	0.99	0.982	0.98	0.97

TF superclass	Immunoglobulin fold {6} (TFClass)
TF class	Rel homology region (RHR) factors {6.1} (TFClass)
TF family	NFAT-related {6.1.3} (TFClass)
TF subfamily	{6.1.3.0} (TFClass)
TFClass ID	TFClass: 6.1.3.0.2
HGNC	HGNC:7776
MGI	MGI:102463
EntrezGene (human)	GeneID:4773 (SSTAR profile)
EntrezGene (mouse)	GeneID:18019 (SSTAR profile)
UniProt ID (human)	NFAC2_HUMAN
UniProt ID (mouse)	NFAC2_MOUSE
UniProt AC (human)	Q13469 (TFClass)
UniProt AC (mouse)	Q60591 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	2 human, 1 mouse
HT-SELEX	2
Methyl-HT-SELEX	2

PCM	NFAC2.H12INVIVO.1.PS.A.pcm
PWM	NFAC2.H12INVIVO.1.PS.A.pwm
PFM	NFAC2.H12INVIVO.1.PS.A.pfm
Alignment	NFAC2.H12INVIVO.1.PS.A.words.tsv
Threshold to P-value map	NFAC2.H12INVIVO.1.PS.A.thr
Motif in other formats
JASPAR format	NFAC2.H12INVIVO.1.PS.A_jaspar_format.txt
MEME format	NFAC2.H12INVIVO.1.PS.A_meme_format.meme
Transfac format	NFAC2.H12INVIVO.1.PS.A_transfac_format.txt
Homer format	NFAC2.H12INVIVO.1.PS.A_homer_format_0.001.txt NFAC2.H12INVIVO.1.PS.A_homer_format_0.0005.txt NFAC2.H12INVIVO.1.PS.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	166.0	246.0	440.0	156.0
02	200.0	245.0	412.0	151.0
03	518.0	143.0	243.0	104.0
04	468.0	151.0	298.0	91.0
05	252.0	65.0	48.0	643.0
06	37.0	3.0	954.0	14.0
07	56.0	14.0	927.0	11.0
08	917.0	43.0	33.0	15.0
09	882.0	16.0	101.0	9.0
10	715.0	51.0	113.0	129.0
11	399.0	235.0	238.0	136.0
12	502.0	64.0	125.0	317.0

PFM

	A	C	G	T
01	0.165	0.244	0.437	0.155
02	0.198	0.243	0.409	0.15
03	0.514	0.142	0.241	0.103
04	0.464	0.15	0.296	0.09
05	0.25	0.064	0.048	0.638
06	0.037	0.003	0.946	0.014
07	0.056	0.014	0.92	0.011
08	0.91	0.043	0.033	0.015
09	0.875	0.016	0.1	0.009
10	0.709	0.051	0.112	0.128
11	0.396	0.233	0.236	0.135
12	0.498	0.063	0.124	0.314

PWM

	A	C	G	T
01	-0.414	-0.024	0.554	-0.475
02	-0.229	-0.028	0.489	-0.508
03	0.717	-0.561	-0.036	-0.875
04	0.616	-0.508	0.167	-1.007
05	0.0	-1.336	-1.63	0.933
06	-1.88	-3.983	1.326	-2.781
07	-1.481	-2.781	1.298	-2.992
08	1.287	-1.736	-1.989	-2.719
09	1.248	-2.661	-0.904	-3.163
10	1.038	-1.571	-0.794	-0.663
11	0.457	-0.069	-0.057	-0.611
12	0.686	-1.351	-0.694	0.228

Standard thresholds

P-value	Threshold
0.001	4.999815
0.0005	5.734865
0.0001	7.183435