NFAC2.H12INVITRO.4.M.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	NFAC2.H12INVITRO.4.M.B
Gene (human)	NFATC2 (GeneCards)
Gene synonyms (human)	NFAT1, NFATP
Gene (mouse)	Nfatc2
Gene synonyms (mouse)	Nfat1, Nfatp
LOGO
LOGO (reverse complement)
Motif subtype	4
Quality	B

Motif length	19
Consensus	dWTYYvnhhACGGAAAhWn
GC content	39.42%
Information content (bits; total / per base)	16.744 / 0.881
Data sources	Methyl-HT-SELEX
Aligned words	8781

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	2 (10)	0.737	0.762	0.591	0.623	0.706	0.723	1.92	2.065	42.227	83.161
Mouse	1 (7)	0.794	0.806	0.645	0.654	0.738	0.742	2.0	2.036	71.051	81.824

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.993	0.99	0.98	0.971	0.939	0.926
Overall, 4 experiments	best	1.0	1.0	1.0	0.999	0.986	0.984
Methyl HT-SELEX, 2 experiments	median	0.986	0.98	0.972	0.96	0.935	0.921
Methyl HT-SELEX, 2 experiments	best	1.0	1.0	1.0	0.999	0.986	0.984
Non-Methyl HT-SELEX, 2 experiments	median	0.993	0.99	0.98	0.971	0.939	0.926
Non-Methyl HT-SELEX, 2 experiments	best	0.999	0.999	0.988	0.984	0.948	0.94

TF superclass	Immunoglobulin fold {6} (TFClass)
TF class	Rel homology region (RHR) factors {6.1} (TFClass)
TF family	NFAT-related {6.1.3} (TFClass)
TF subfamily	{6.1.3.0} (TFClass)
TFClass ID	TFClass: 6.1.3.0.2
HGNC	HGNC:7776
MGI	MGI:102463
EntrezGene (human)	GeneID:4773 (SSTAR profile)
EntrezGene (mouse)	GeneID:18019 (SSTAR profile)
UniProt ID (human)	NFAC2_HUMAN
UniProt ID (mouse)	NFAC2_MOUSE
UniProt AC (human)	Q13469 (TFClass)
UniProt AC (mouse)	Q60591 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	2 human, 1 mouse
HT-SELEX	2
Methyl-HT-SELEX	2

PCM	NFAC2.H12INVITRO.4.M.B.pcm
PWM	NFAC2.H12INVITRO.4.M.B.pwm
PFM	NFAC2.H12INVITRO.4.M.B.pfm
Alignment	NFAC2.H12INVITRO.4.M.B.words.tsv
Threshold to P-value map	NFAC2.H12INVITRO.4.M.B.thr
Motif in other formats
JASPAR format	NFAC2.H12INVITRO.4.M.B_jaspar_format.txt
MEME format	NFAC2.H12INVITRO.4.M.B_meme_format.meme
Transfac format	NFAC2.H12INVITRO.4.M.B_transfac_format.txt
Homer format	NFAC2.H12INVITRO.4.M.B_homer_format_0.001.txt NFAC2.H12INVITRO.4.M.B_homer_format_0.0005.txt NFAC2.H12INVITRO.4.M.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1483.25	1383.25	1624.25	4290.25
02	984.5	750.5	940.5	6105.5
03	709.0	418.0	511.0	7143.0
04	591.0	3317.0	419.0	4454.0
05	502.0	6699.0	360.0	1220.0
06	1535.0	3961.0	2198.0	1087.0
07	2007.0	1647.0	2584.0	2543.0
08	1202.0	2442.0	1087.0	4050.0
09	4179.0	1359.0	595.0	2648.0
10	6775.0	17.0	1858.0	131.0
11	0.0	6606.0	0.0	2175.0
12	0.0	0.0	8781.0	0.0
13	0.0	0.0	8781.0	0.0
14	8781.0	0.0	0.0	0.0
15	8781.0	0.0	0.0	0.0
16	8224.0	444.0	9.0	104.0
17	4457.0	2020.0	1132.0	1172.0
18	3249.75	432.75	380.75	4717.75
19	2528.75	1593.75	1422.75	3235.75

PFM

	A	C	G	T
01	0.169	0.158	0.185	0.489
02	0.112	0.085	0.107	0.695
03	0.081	0.048	0.058	0.813
04	0.067	0.378	0.048	0.507
05	0.057	0.763	0.041	0.139
06	0.175	0.451	0.25	0.124
07	0.229	0.188	0.294	0.29
08	0.137	0.278	0.124	0.461
09	0.476	0.155	0.068	0.302
10	0.772	0.002	0.212	0.015
11	0.0	0.752	0.0	0.248
12	0.0	0.0	1.0	0.0
13	0.0	0.0	1.0	0.0
14	1.0	0.0	0.0	0.0
15	1.0	0.0	0.0	0.0
16	0.937	0.051	0.001	0.012
17	0.508	0.23	0.129	0.133
18	0.37	0.049	0.043	0.537
19	0.288	0.181	0.162	0.368

PWM

	A	C	G	T
01	-0.392	-0.461	-0.301	0.67
02	-0.801	-1.071	-0.846	1.022
03	-1.128	-1.654	-1.454	1.179
04	-1.309	0.412	-1.652	0.707
05	-1.472	1.115	-1.803	-0.587
06	-0.357	0.59	0.001	-0.702
07	-0.09	-0.287	0.163	0.147
08	-0.601	0.106	-0.702	0.612
09	0.643	-0.479	-1.303	0.187
10	1.126	-4.737	-0.167	-2.803
11	-6.875	1.101	-6.875	-0.009
12	-6.875	-6.875	1.386	-6.875
13	-6.875	-6.875	1.386	-6.875
14	1.386	-6.875	-6.875	-6.875
15	1.386	-6.875	-6.875	-6.875
16	1.32	-1.594	-5.273	-3.029
17	0.708	-0.083	-0.661	-0.627
18	0.392	-1.62	-1.747	0.764
19	0.141	-0.32	-0.433	0.388

Standard thresholds

P-value	Threshold
0.001	0.08426
0.0005	1.94301
0.0001	5.70231