NFAC2.H12INVITRO.3.M.C motif - HOmo sapiens COmprehensive MOdel COllection

Motif	NFAC2.H12INVITRO.3.M.C
Gene (human)	NFATC2 (GeneCards)
Gene synonyms (human)	NFAT1, NFATP
Gene (mouse)	Nfatc2
Gene synonyms (mouse)	Nfat1, Nfatp
LOGO
LOGO (reverse complement)
Motif subtype	3
Quality	C

Motif length	10
Consensus	nhRCGGAAMn
GC content	45.4%
Information content (bits; total / per base)	10.772 / 1.077
Data sources	Methyl-HT-SELEX
Aligned words	7846

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	2 (10)	0.728	0.764	0.516	0.603	0.732	0.752	2.092	2.172	75.71	133.699
Mouse	1 (7)	0.805	0.815	0.677	0.692	0.761	0.768	2.045	2.081	122.921	136.319

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.981	0.968	0.975	0.959	0.961	0.941
Overall, 4 experiments	best	0.997	0.996	0.994	0.991	0.983	0.978
Methyl HT-SELEX, 2 experiments	median	0.976	0.96	0.968	0.949	0.948	0.926
Methyl HT-SELEX, 2 experiments	best	0.997	0.996	0.994	0.991	0.983	0.978
Non-Methyl HT-SELEX, 2 experiments	median	0.981	0.968	0.975	0.959	0.961	0.941
Non-Methyl HT-SELEX, 2 experiments	best	0.992	0.987	0.988	0.98	0.981	0.971

TF superclass	Immunoglobulin fold {6} (TFClass)
TF class	Rel homology region (RHR) factors {6.1} (TFClass)
TF family	NFAT-related {6.1.3} (TFClass)
TF subfamily	{6.1.3.0} (TFClass)
TFClass ID	TFClass: 6.1.3.0.2
HGNC	HGNC:7776
MGI	MGI:102463
EntrezGene (human)	GeneID:4773 (SSTAR profile)
EntrezGene (mouse)	GeneID:18019 (SSTAR profile)
UniProt ID (human)	NFAC2_HUMAN
UniProt ID (mouse)	NFAC2_MOUSE
UniProt AC (human)	Q13469 (TFClass)
UniProt AC (mouse)	Q60591 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	2 human, 1 mouse
HT-SELEX	2
Methyl-HT-SELEX	2

PCM	NFAC2.H12INVITRO.3.M.C.pcm
PWM	NFAC2.H12INVITRO.3.M.C.pwm
PFM	NFAC2.H12INVITRO.3.M.C.pfm
Alignment	NFAC2.H12INVITRO.3.M.C.words.tsv
Threshold to P-value map	NFAC2.H12INVITRO.3.M.C.thr
Motif in other formats
JASPAR format	NFAC2.H12INVITRO.3.M.C_jaspar_format.txt
MEME format	NFAC2.H12INVITRO.3.M.C_meme_format.meme
Transfac format	NFAC2.H12INVITRO.3.M.C_transfac_format.txt
Homer format	NFAC2.H12INVITRO.3.M.C_homer_format_0.001.txt NFAC2.H12INVITRO.3.M.C_homer_format_0.0005.txt NFAC2.H12INVITRO.3.M.C_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1687.25	2223.25	1909.25	2026.25
02	3085.25	1857.25	956.25	1947.25
03	5379.0	206.0	2071.0	190.0
04	0.0	5016.0	0.0	2830.0
05	0.0	0.0	7846.0	0.0
06	0.0	0.0	7846.0	0.0
07	7846.0	0.0	0.0	0.0
08	7846.0	0.0	0.0	0.0
09	5391.0	1544.0	168.0	743.0
10	2393.75	1856.75	2119.75	1475.75

PFM

	A	C	G	T
01	0.215	0.283	0.243	0.258
02	0.393	0.237	0.122	0.248
03	0.686	0.026	0.264	0.024
04	0.0	0.639	0.0	0.361
05	0.0	0.0	1.0	0.0
06	0.0	0.0	1.0	0.0
07	1.0	0.0	0.0	0.0
08	1.0	0.0	0.0	0.0
09	0.687	0.197	0.021	0.095
10	0.305	0.237	0.27	0.188

PWM

	A	C	G	T
01	-0.15	0.125	-0.027	0.032
02	0.453	-0.055	-0.717	-0.007
03	1.008	-2.244	0.054	-2.324
04	-6.775	0.938	-6.775	0.366
05	-6.775	-6.775	1.385	-6.775
06	-6.775	-6.775	1.385	-6.775
07	1.385	-6.775	-6.775	-6.775
08	1.385	-6.775	-6.775	-6.775
09	1.01	-0.239	-2.445	-0.969
10	0.199	-0.055	0.078	-0.284

Standard thresholds

P-value	Threshold
0.001	4.48209
0.0005	5.95807
0.0001	7.843215