NFAC2.H12INVITRO.1.PS.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	NFAC2.H12INVITRO.1.PS.A
Gene (human)	NFATC2 (GeneCards)
Gene synonyms (human)	NFAT1, NFATP
Gene (mouse)	Nfatc2
Gene synonyms (mouse)	Nfat1, Nfatp
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	A

Motif length	11
Consensus	nRTGGAAMnnn
GC content	44.57%
Information content (bits; total / per base)	10.63 / 0.966
Data sources	ChIP-Seq + HT-SELEX
Aligned words	8563

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	2 (10)	0.741	0.774	0.547	0.628	0.737	0.754	2.097	2.209	73.789	138.174
Mouse	1 (7)	0.817	0.827	0.688	0.711	0.776	0.785	2.193	2.254	122.319	127.62

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.98	0.966	0.973	0.956	0.958	0.937
Overall, 4 experiments	best	0.995	0.992	0.992	0.988	0.985	0.978
Methyl HT-SELEX, 2 experiments	median	0.969	0.949	0.961	0.937	0.942	0.915
Methyl HT-SELEX, 2 experiments	best	0.992	0.987	0.986	0.978	0.977	0.965
Non-Methyl HT-SELEX, 2 experiments	median	0.982	0.969	0.976	0.961	0.962	0.943
Non-Methyl HT-SELEX, 2 experiments	best	0.995	0.992	0.992	0.988	0.985	0.978

TF superclass	Immunoglobulin fold {6} (TFClass)
TF class	Rel homology region (RHR) factors {6.1} (TFClass)
TF family	NFAT-related {6.1.3} (TFClass)
TF subfamily	{6.1.3.0} (TFClass)
TFClass ID	TFClass: 6.1.3.0.2
HGNC	HGNC:7776
MGI	MGI:102463
EntrezGene (human)	GeneID:4773 (SSTAR profile)
EntrezGene (mouse)	GeneID:18019 (SSTAR profile)
UniProt ID (human)	NFAC2_HUMAN
UniProt ID (mouse)	NFAC2_MOUSE
UniProt AC (human)	Q13469 (TFClass)
UniProt AC (mouse)	Q60591 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	2 human, 1 mouse
HT-SELEX	2
Methyl-HT-SELEX	2

PCM	NFAC2.H12INVITRO.1.PS.A.pcm
PWM	NFAC2.H12INVITRO.1.PS.A.pwm
PFM	NFAC2.H12INVITRO.1.PS.A.pfm
Alignment	NFAC2.H12INVITRO.1.PS.A.words.tsv
Threshold to P-value map	NFAC2.H12INVITRO.1.PS.A.thr
Motif in other formats
JASPAR format	NFAC2.H12INVITRO.1.PS.A_jaspar_format.txt
MEME format	NFAC2.H12INVITRO.1.PS.A_meme_format.meme
Transfac format	NFAC2.H12INVITRO.1.PS.A_transfac_format.txt
Homer format	NFAC2.H12INVITRO.1.PS.A_homer_format_0.001.txt NFAC2.H12INVITRO.1.PS.A_homer_format_0.0005.txt NFAC2.H12INVITRO.1.PS.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2183.25	2425.25	2121.25	1833.25
02	4185.5	455.5	3510.5	411.5
03	3.0	2132.0	6.0	6422.0
04	0.0	0.0	8563.0	0.0
05	0.0	0.0	8563.0	0.0
06	8563.0	0.0	0.0	0.0
07	8563.0	0.0	0.0	0.0
08	6183.0	1331.0	247.0	802.0
09	2179.0	1749.0	3027.0	1608.0
10	1917.0	1374.0	1941.0	3331.0
11	1682.0	2121.0	2413.0	2347.0

PFM

	A	C	G	T
01	0.255	0.283	0.248	0.214
02	0.489	0.053	0.41	0.048
03	0.0	0.249	0.001	0.75
04	0.0	0.0	1.0	0.0
05	0.0	0.0	1.0	0.0
06	1.0	0.0	0.0	0.0
07	1.0	0.0	0.0	0.0
08	0.722	0.155	0.029	0.094
09	0.254	0.204	0.353	0.188
10	0.224	0.16	0.227	0.389
11	0.196	0.248	0.282	0.274

PWM

	A	C	G	T
01	0.02	0.125	-0.009	-0.155
02	0.67	-1.544	0.494	-1.645
03	-6.009	-0.004	-5.558	1.098
04	-6.853	-6.853	1.386	-6.853
05	-6.853	-6.853	1.386	-6.853
06	1.386	-6.853	-6.853	-6.853
07	1.386	-6.853	-6.853	-6.853
08	1.06	-0.475	-2.151	-0.98
09	0.018	-0.202	0.346	-0.286
10	-0.11	-0.443	-0.098	0.442
11	-0.241	-0.009	0.12	0.092

Standard thresholds

P-value	Threshold
0.001	4.79323
0.0005	6.04273
0.0001	7.84479