NFAC2.H12CORE.1.PS.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	NFAC2.H12CORE.1.PS.A
Gene (human)	NFATC2 (GeneCards)
Gene synonyms (human)	NFAT1, NFATP
Gene (mouse)	Nfatc2
Gene synonyms (mouse)	Nfat1, Nfatp
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	A

Motif length	11
Consensus	nvRWGGAAWvd
GC content	38.46%
Information content (bits; total / per base)	10.379 / 0.944
Data sources	ChIP-Seq + HT-SELEX
Aligned words	1010

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	2 (10)	0.745	0.785	0.541	0.629	0.788	0.811	2.546	2.723	87.112	164.056
Mouse	1 (7)	0.829	0.834	0.672	0.683	0.814	0.823	2.403	2.454	128.149	137.921

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 4 experiments	median	0.978	0.962	0.963	0.943	0.935	0.91
Overall, 4 experiments	best	0.993	0.988	0.991	0.985	0.985	0.976
Methyl HT-SELEX, 2 experiments	median	0.961	0.936	0.943	0.914	0.909	0.877
Methyl HT-SELEX, 2 experiments	best	0.988	0.979	0.977	0.965	0.951	0.934
Non-Methyl HT-SELEX, 2 experiments	median	0.98	0.966	0.97	0.953	0.952	0.931
Non-Methyl HT-SELEX, 2 experiments	best	0.993	0.988	0.991	0.985	0.985	0.976

TF superclass	Immunoglobulin fold {6} (TFClass)
TF class	Rel homology region (RHR) factors {6.1} (TFClass)
TF family	NFAT-related {6.1.3} (TFClass)
TF subfamily	{6.1.3.0} (TFClass)
TFClass ID	TFClass: 6.1.3.0.2
HGNC	HGNC:7776
MGI	MGI:102463
EntrezGene (human)	GeneID:4773 (SSTAR profile)
EntrezGene (mouse)	GeneID:18019 (SSTAR profile)
UniProt ID (human)	NFAC2_HUMAN
UniProt ID (mouse)	NFAC2_MOUSE
UniProt AC (human)	Q13469 (TFClass)
UniProt AC (mouse)	Q60591 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	2 human, 1 mouse
HT-SELEX	2
Methyl-HT-SELEX	2

PCM	NFAC2.H12CORE.1.PS.A.pcm
PWM	NFAC2.H12CORE.1.PS.A.pwm
PFM	NFAC2.H12CORE.1.PS.A.pfm
Alignment	NFAC2.H12CORE.1.PS.A.words.tsv
Threshold to P-value map	NFAC2.H12CORE.1.PS.A.thr
Motif in other formats
JASPAR format	NFAC2.H12CORE.1.PS.A_jaspar_format.txt
MEME format	NFAC2.H12CORE.1.PS.A_meme_format.meme
Transfac format	NFAC2.H12CORE.1.PS.A_transfac_format.txt
Homer format	NFAC2.H12CORE.1.PS.A_homer_format_0.001.txt NFAC2.H12CORE.1.PS.A_homer_format_0.0005.txt NFAC2.H12CORE.1.PS.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	219.0	239.0	393.0	159.0
02	570.0	158.0	197.0	85.0
03	552.0	87.0	310.0	61.0
04	166.0	38.0	57.0	749.0
05	7.0	0.0	1001.0	2.0
06	7.0	13.0	986.0	4.0
07	990.0	8.0	8.0	4.0
08	970.0	9.0	29.0	2.0
09	787.0	57.0	42.0	124.0
10	414.0	238.0	213.0	145.0
11	472.0	47.0	143.0	348.0

PFM

	A	C	G	T
01	0.217	0.237	0.389	0.157
02	0.564	0.156	0.195	0.084
03	0.547	0.086	0.307	0.06
04	0.164	0.038	0.056	0.742
05	0.007	0.0	0.991	0.002
06	0.007	0.013	0.976	0.004
07	0.98	0.008	0.008	0.004
08	0.96	0.009	0.029	0.002
09	0.779	0.056	0.042	0.123
10	0.41	0.236	0.211	0.144
11	0.467	0.047	0.142	0.345

PWM

	A	C	G	T
01	-0.141	-0.055	0.44	-0.459
02	0.81	-0.465	-0.246	-1.075
03	0.778	-1.053	0.204	-1.399
04	-0.416	-1.856	-1.465	1.083
05	-3.372	-4.99	1.372	-4.222
06	-3.372	-2.848	1.357	-3.793
07	1.361	-3.263	-3.263	-3.793
08	1.341	-3.165	-2.113	-4.222
09	1.132	-1.465	-1.76	-0.704
10	0.492	-0.059	-0.169	-0.55
11	0.622	-1.652	-0.563	0.319

Standard thresholds

P-value	Threshold
0.001	4.68438
0.0005	5.63614
0.0001	7.450495