NFAC1.H12INVIVO.0.P.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	NFAC1.H12INVIVO.0.P.B
Gene (human)	NFATC1 (GeneCards)
Gene synonyms (human)	NFAT2, NFATC
Gene (mouse)	Nfatc1
Gene synonyms (mouse)	Nfat2, Nfatc
LOGO
LOGO (reverse complement)
Motif subtype	0
Quality	B

Motif length	16
Consensus	WGGAARvdnTKWvhMW
GC content	39.55%
Information content (bits; total / per base)	14.203 / 0.888
Data sources	ChIP-Seq
Aligned words	928

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	3 (16)	0.579	0.789	0.478	0.725	0.597	0.792	1.791	2.99	23.992	83.658
Mouse	3 (18)	0.861	0.93	0.831	0.892	0.865	0.933	4.188	4.632	348.626	505.699

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 6 experiments	median	0.807	0.749	0.732	0.682	0.667	0.633
Overall, 6 experiments	best	0.944	0.907	0.917	0.876	0.852	0.816
Methyl HT-SELEX, 2 experiments	median	0.881	0.829	0.841	0.791	0.775	0.737
Methyl HT-SELEX, 2 experiments	best	0.944	0.907	0.917	0.876	0.852	0.816
Non-Methyl HT-SELEX, 4 experiments	median	0.773	0.722	0.687	0.652	0.612	0.601
Non-Methyl HT-SELEX, 4 experiments	best	0.903	0.856	0.833	0.79	0.724	0.707

TF superclass	Immunoglobulin fold {6} (TFClass)
TF class	Rel homology region (RHR) factors {6.1} (TFClass)
TF family	NFAT-related {6.1.3} (TFClass)
TF subfamily	{6.1.3.0} (TFClass)
TFClass ID	TFClass: 6.1.3.0.1
HGNC	HGNC:7775
MGI	MGI:102469
EntrezGene (human)	GeneID:4772 (SSTAR profile)
EntrezGene (mouse)
UniProt ID (human)	NFAC1_HUMAN
UniProt ID (mouse)	NFAC1_MOUSE
UniProt AC (human)	O95644 (TFClass)
UniProt AC (mouse)	O88942 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	3 human, 3 mouse
HT-SELEX	4
Methyl-HT-SELEX	2

PCM	NFAC1.H12INVIVO.0.P.B.pcm
PWM	NFAC1.H12INVIVO.0.P.B.pwm
PFM	NFAC1.H12INVIVO.0.P.B.pfm
Alignment	NFAC1.H12INVIVO.0.P.B.words.tsv
Threshold to P-value map	NFAC1.H12INVIVO.0.P.B.thr
Motif in other formats
JASPAR format	NFAC1.H12INVIVO.0.P.B_jaspar_format.txt
MEME format	NFAC1.H12INVIVO.0.P.B_meme_format.meme
Transfac format	NFAC1.H12INVIVO.0.P.B_transfac_format.txt
Homer format	NFAC1.H12INVIVO.0.P.B_homer_format_0.001.txt NFAC1.H12INVIVO.0.P.B_homer_format_0.0005.txt NFAC1.H12INVIVO.0.P.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	178.0	48.0	65.0	637.0
02	10.0	1.0	915.0	2.0
03	1.0	1.0	925.0	1.0
04	879.0	19.0	29.0	1.0
05	879.0	2.0	36.0	11.0
06	734.0	53.0	87.0	54.0
07	462.0	171.0	210.0	85.0
08	382.0	65.0	103.0	378.0
09	321.0	230.0	230.0	147.0
10	56.0	45.0	43.0	784.0
11	46.0	64.0	659.0	159.0
12	709.0	49.0	72.0	98.0
13	122.0	307.0	424.0	75.0
14	95.0	95.0	71.0	667.0
15	163.0	587.0	91.0	87.0
16	646.0	76.0	99.0	107.0

PFM

	A	C	G	T
01	0.192	0.052	0.07	0.686
02	0.011	0.001	0.986	0.002
03	0.001	0.001	0.997	0.001
04	0.947	0.02	0.031	0.001
05	0.947	0.002	0.039	0.012
06	0.791	0.057	0.094	0.058
07	0.498	0.184	0.226	0.092
08	0.412	0.07	0.111	0.407
09	0.346	0.248	0.248	0.158
10	0.06	0.048	0.046	0.845
11	0.05	0.069	0.71	0.171
12	0.764	0.053	0.078	0.106
13	0.131	0.331	0.457	0.081
14	0.102	0.102	0.077	0.719
15	0.176	0.633	0.098	0.094
16	0.696	0.082	0.107	0.115

PWM

	A	C	G	T
01	-0.263	-1.548	-1.254	1.005
02	-2.994	-4.458	1.367	-4.144
03	-4.458	-4.458	1.378	-4.458
04	1.327	-2.424	-2.03	-4.458
05	1.327	-4.144	-1.824	-2.912
06	1.147	-1.452	-0.969	-1.434
07	0.685	-0.302	-0.099	-0.992
08	0.496	-1.254	-0.803	0.485
09	0.323	-0.009	-0.009	-0.452
10	-1.399	-1.61	-1.654	1.213
11	-1.589	-1.269	1.039	-0.374
12	1.112	-1.528	-1.154	-0.852
13	-0.636	0.278	0.6	-1.114
14	-0.882	-0.882	-1.168	1.051
15	-0.35	0.924	-0.925	-0.969
16	1.019	-1.101	-0.842	-0.765

Standard thresholds

P-value	Threshold
0.001	3.48336
0.0005	4.56926
0.0001	6.80936