NFAC1.H12INVITRO.2.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	NFAC1.H12INVITRO.2.SM.B
Gene (human)	NFATC1 (GeneCards)
Gene synonyms (human)	NFAT2, NFATC
Gene (mouse)	Nfatc1
Gene synonyms (mouse)	Nfat2, Nfatc
LOGO
LOGO (reverse complement)
Motif subtype	2
Quality	B

Motif length	19
Consensus	dWWhYnnbhRCGGAAAMWn
GC content	39.31%
Information content (bits; total / per base)	15.72 / 0.827
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	8933

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	3 (16)	0.601	0.735	0.454	0.605	0.585	0.729	1.503	2.182	14.513	41.276
Mouse	3 (18)	0.715	0.813	0.581	0.668	0.678	0.775	1.926	2.326	110.592	186.678

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 6 experiments	median	0.957	0.939	0.884	0.866	0.737	0.751
Overall, 6 experiments	best	1.0	1.0	0.998	0.997	0.965	0.964
Methyl HT-SELEX, 2 experiments	median	0.991	0.988	0.972	0.964	0.882	0.887
Methyl HT-SELEX, 2 experiments	best	1.0	1.0	0.998	0.997	0.965	0.964
Non-Methyl HT-SELEX, 4 experiments	median	0.896	0.874	0.748	0.747	0.629	0.651
Non-Methyl HT-SELEX, 4 experiments	best	0.994	0.992	0.95	0.943	0.792	0.809

TF superclass	Immunoglobulin fold {6} (TFClass)
TF class	Rel homology region (RHR) factors {6.1} (TFClass)
TF family	NFAT-related {6.1.3} (TFClass)
TF subfamily	{6.1.3.0} (TFClass)
TFClass ID	TFClass: 6.1.3.0.1
HGNC	HGNC:7775
MGI	MGI:102469
EntrezGene (human)	GeneID:4772 (SSTAR profile)
EntrezGene (mouse)
UniProt ID (human)	NFAC1_HUMAN
UniProt ID (mouse)	NFAC1_MOUSE
UniProt AC (human)	O95644 (TFClass)
UniProt AC (mouse)	O88942 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	3 human, 3 mouse
HT-SELEX	4
Methyl-HT-SELEX	2

PCM	NFAC1.H12INVITRO.2.SM.B.pcm
PWM	NFAC1.H12INVITRO.2.SM.B.pwm
PFM	NFAC1.H12INVITRO.2.SM.B.pfm
Alignment	NFAC1.H12INVITRO.2.SM.B.words.tsv
Threshold to P-value map	NFAC1.H12INVITRO.2.SM.B.thr
Motif in other formats
JASPAR format	NFAC1.H12INVITRO.2.SM.B_jaspar_format.txt
MEME format	NFAC1.H12INVITRO.2.SM.B_meme_format.meme
Transfac format	NFAC1.H12INVITRO.2.SM.B_transfac_format.txt
Homer format	NFAC1.H12INVITRO.2.SM.B_homer_format_0.001.txt NFAC1.H12INVITRO.2.SM.B_homer_format_0.0005.txt NFAC1.H12INVITRO.2.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	1680.25	1295.25	1609.25	4348.25
02	1349.75	968.75	977.75	5636.75
03	1178.0	749.0	718.0	6288.0
04	889.0	3237.0	719.0	4088.0
05	648.0	5252.0	530.0	2503.0
06	1514.0	3022.0	2233.0	2164.0
07	1545.0	1989.0	2050.0	3349.0
08	1335.0	3321.0	1379.0	2898.0
09	3464.0	2274.0	879.0	2316.0
10	6424.0	25.0	2250.0	234.0
11	2.0	6516.0	0.0	2415.0
12	0.0	0.0	8933.0	0.0
13	0.0	0.0	8933.0	0.0
14	8933.0	0.0	0.0	0.0
15	8933.0	0.0	0.0	0.0
16	8801.0	109.0	1.0	22.0
17	5587.0	1738.0	940.0	668.0
18	3032.5	480.5	327.5	5092.5
19	2662.5	1466.5	1796.5	3007.5

PFM

	A	C	G	T
01	0.188	0.145	0.18	0.487
02	0.151	0.108	0.109	0.631
03	0.132	0.084	0.08	0.704
04	0.1	0.362	0.08	0.458
05	0.073	0.588	0.059	0.28
06	0.169	0.338	0.25	0.242
07	0.173	0.223	0.229	0.375
08	0.149	0.372	0.154	0.324
09	0.388	0.255	0.098	0.259
10	0.719	0.003	0.252	0.026
11	0.0	0.729	0.0	0.27
12	0.0	0.0	1.0	0.0
13	0.0	0.0	1.0	0.0
14	1.0	0.0	0.0	0.0
15	1.0	0.0	0.0	0.0
16	0.985	0.012	0.0	0.002
17	0.625	0.195	0.105	0.075
18	0.339	0.054	0.037	0.57
19	0.298	0.164	0.201	0.337

PWM

	A	C	G	T
01	-0.284	-0.544	-0.327	0.666
02	-0.503	-0.834	-0.825	0.925
03	-0.639	-1.09	-1.133	1.035
04	-0.92	0.371	-1.131	0.604
05	-1.235	0.855	-1.435	0.114
06	-0.388	0.302	-0.0	-0.031
07	-0.368	-0.116	-0.086	0.405
08	-0.514	0.396	-0.481	0.26
09	0.439	0.018	-0.931	0.036
10	1.056	-4.406	0.007	-2.247
11	-6.26	1.07	-6.891	0.078
12	-6.891	-6.891	1.386	-6.891
13	-6.891	-6.891	1.386	-6.891
14	1.386	-6.891	-6.891	-6.891
15	1.386	-6.891	-6.891	-6.891
16	1.371	-3.0	-6.526	-4.523
17	0.916	-0.25	-0.864	-1.205
18	0.306	-1.533	-1.914	0.824
19	0.176	-0.42	-0.217	0.297

Standard thresholds

P-value	Threshold
0.001	0.35276
0.0005	2.14256
0.0001	6.14891