NFAC1.H12INVITRO.1.PS.A motif - HOmo sapiens COmprehensive MOdel COllection

Motif	NFAC1.H12INVITRO.1.PS.A
Gene (human)	NFATC1 (GeneCards)
Gene synonyms (human)	NFAT2, NFATC
Gene (mouse)	Nfatc1
Gene synonyms (mouse)	Nfat2, Nfatc
LOGO
LOGO (reverse complement)
Motif subtype	1
Quality	A

Motif length	11
Consensus	hRTGGAAAdhh
GC content	33.92%
Information content (bits; total / per base)	12.195 / 1.109
Data sources	ChIP-Seq + HT-SELEX
Aligned words	6892

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	3 (16)	0.601	0.741	0.466	0.608	0.585	0.769	1.597	2.535	21.906	60.387
Mouse	3 (18)	0.73	0.825	0.615	0.708	0.733	0.829	2.272	2.801	169.428	283.854

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 6 experiments	median	0.966	0.95	0.905	0.88	0.764	0.77
Overall, 6 experiments	best	0.995	0.991	0.992	0.987	0.971	0.964
Methyl HT-SELEX, 2 experiments	median	0.983	0.972	0.971	0.956	0.898	0.894
Methyl HT-SELEX, 2 experiments	best	0.995	0.991	0.992	0.987	0.971	0.964
Non-Methyl HT-SELEX, 4 experiments	median	0.952	0.931	0.828	0.818	0.675	0.698
Non-Methyl HT-SELEX, 4 experiments	best	0.99	0.983	0.959	0.948	0.822	0.83

TF superclass	Immunoglobulin fold {6} (TFClass)
TF class	Rel homology region (RHR) factors {6.1} (TFClass)
TF family	NFAT-related {6.1.3} (TFClass)
TF subfamily	{6.1.3.0} (TFClass)
TFClass ID	TFClass: 6.1.3.0.1
HGNC	HGNC:7775
MGI	MGI:102469
EntrezGene (human)	GeneID:4772 (SSTAR profile)
EntrezGene (mouse)
UniProt ID (human)	NFAC1_HUMAN
UniProt ID (mouse)	NFAC1_MOUSE
UniProt AC (human)	O95644 (TFClass)
UniProt AC (mouse)	O88942 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	3 human, 3 mouse
HT-SELEX	4
Methyl-HT-SELEX	2

PCM	NFAC1.H12INVITRO.1.PS.A.pcm
PWM	NFAC1.H12INVITRO.1.PS.A.pwm
PFM	NFAC1.H12INVITRO.1.PS.A.pfm
Alignment	NFAC1.H12INVITRO.1.PS.A.words.tsv
Threshold to P-value map	NFAC1.H12INVITRO.1.PS.A.thr
Motif in other formats
JASPAR format	NFAC1.H12INVITRO.1.PS.A_jaspar_format.txt
MEME format	NFAC1.H12INVITRO.1.PS.A_meme_format.meme
Transfac format	NFAC1.H12INVITRO.1.PS.A_transfac_format.txt
Homer format	NFAC1.H12INVITRO.1.PS.A_homer_format_0.001.txt NFAC1.H12INVITRO.1.PS.A_homer_format_0.0005.txt NFAC1.H12INVITRO.1.PS.A_homer_format_0.0001.txt

PCM

	A	C	G	T
01	3171.0	1218.0	1145.0	1358.0
02	4423.0	383.0	1463.0	623.0
03	67.0	1906.0	0.0	4919.0
04	0.0	0.0	6892.0	0.0
05	0.0	0.0	6892.0	0.0
06	6892.0	0.0	0.0	0.0
07	6892.0	0.0	0.0	0.0
08	6553.0	176.0	44.0	119.0
09	3604.0	1038.0	1130.0	1120.0
10	2183.0	582.0	526.0	3601.0
11	1750.5	1167.5	1150.5	2823.5

PFM

	A	C	G	T
01	0.46	0.177	0.166	0.197
02	0.642	0.056	0.212	0.09
03	0.01	0.277	0.0	0.714
04	0.0	0.0	1.0	0.0
05	0.0	0.0	1.0	0.0
06	1.0	0.0	0.0	0.0
07	1.0	0.0	0.0	0.0
08	0.951	0.026	0.006	0.017
09	0.523	0.151	0.164	0.163
10	0.317	0.084	0.076	0.522
11	0.254	0.169	0.167	0.41

PWM

	A	C	G	T
01	0.609	-0.346	-0.408	-0.238
02	0.942	-1.499	-0.163	-1.015
03	-3.216	0.101	-6.66	1.048
04	-6.66	-6.66	1.385	-6.66
05	-6.66	-6.66	1.385	-6.66
06	1.385	-6.66	-6.66	-6.66
07	1.385	-6.66	-6.66	-6.66
08	1.335	-2.27	-3.62	-2.656
09	0.737	-0.506	-0.421	-0.43
10	0.236	-1.083	-1.184	0.736
11	0.016	-0.389	-0.403	0.493

Standard thresholds

P-value	Threshold
0.001	3.113025
0.0005	4.867315
0.0001	7.66608