NFAC1.H12CORE.3.SM.B motif - HOmo sapiens COmprehensive MOdel COllection

Motif	NFAC1.H12CORE.3.SM.B
Gene (human)	NFATC1 (GeneCards)
Gene synonyms (human)	NFAT2, NFATC
Gene (mouse)	Nfatc1
Gene synonyms (mouse)	Nfat2, Nfatc
LOGO
LOGO (reverse complement)
Motif subtype	3
Quality	B

Motif length	14
Consensus	nRCGGAAMdThYvn
GC content	47.39%
Information content (bits; total / per base)	13.129 / 0.938
Data sources	HT-SELEX + Methyl-HT-SELEX
Aligned words	8589

ChIP-Seq benchmarking	Num. of experiments (peaksets)	auROC, median	auROC, best	auPRC, median	auPRC, best	pseudo-auROC, median	pseudo-auROC, best	pseudo-log-auROC, median	pseudo-log-auROC, best	Centrality, median	Centrality, best
Human	3 (16)	0.605	0.713	0.447	0.537	0.564	0.721	1.342	1.92	14.062	43.013
Mouse	3 (18)	0.693	0.785	0.538	0.623	0.647	0.735	1.626	1.942	79.293	151.319

HT-SELEX benchmarking		auROC10	auPRC10	auROC25	auPRC25	auROC50	auPRC50
Overall, 6 experiments	median	0.979	0.968	0.905	0.893	0.76	0.772
Overall, 6 experiments	best	0.997	0.996	0.984	0.974	0.963	0.949
Methyl HT-SELEX, 2 experiments	median	0.993	0.989	0.978	0.971	0.896	0.897
Methyl HT-SELEX, 2 experiments	best	0.997	0.996	0.984	0.974	0.963	0.949
Non-Methyl HT-SELEX, 4 experiments	median	0.953	0.933	0.824	0.823	0.674	0.7
Non-Methyl HT-SELEX, 4 experiments	best	0.986	0.982	0.941	0.917	0.814	0.811

TF superclass	Immunoglobulin fold {6} (TFClass)
TF class	Rel homology region (RHR) factors {6.1} (TFClass)
TF family	NFAT-related {6.1.3} (TFClass)
TF subfamily	{6.1.3.0} (TFClass)
TFClass ID	TFClass: 6.1.3.0.1
HGNC	HGNC:7775
MGI	MGI:102469
EntrezGene (human)	GeneID:4772 (SSTAR profile)
EntrezGene (mouse)
UniProt ID (human)	NFAC1_HUMAN
UniProt ID (mouse)	NFAC1_MOUSE
UniProt AC (human)	O95644 (TFClass)
UniProt AC (mouse)	O88942 (TFClass)
GRECO-DB-TF	yes

ChIP-Seq	3 human, 3 mouse
HT-SELEX	4
Methyl-HT-SELEX	2

PCM	NFAC1.H12CORE.3.SM.B.pcm
PWM	NFAC1.H12CORE.3.SM.B.pwm
PFM	NFAC1.H12CORE.3.SM.B.pfm
Alignment	NFAC1.H12CORE.3.SM.B.words.tsv
Threshold to P-value map	NFAC1.H12CORE.3.SM.B.thr
Motif in other formats
JASPAR format	NFAC1.H12CORE.3.SM.B_jaspar_format.txt
MEME format	NFAC1.H12CORE.3.SM.B_meme_format.meme
Transfac format	NFAC1.H12CORE.3.SM.B_transfac_format.txt
Homer format	NFAC1.H12CORE.3.SM.B_homer_format_0.001.txt NFAC1.H12CORE.3.SM.B_homer_format_0.0005.txt NFAC1.H12CORE.3.SM.B_homer_format_0.0001.txt

PCM

	A	C	G	T
01	2504.5	2476.5	1643.5	1964.5
02	4835.0	179.0	3341.0	234.0
03	3.0	6101.0	0.0	2485.0
04	0.0	0.0	8589.0	0.0
05	0.0	0.0	8589.0	0.0
06	8589.0	0.0	0.0	0.0
07	8589.0	0.0	0.0	0.0
08	5785.0	1787.0	140.0	877.0
09	2393.0	1021.0	1765.0	3410.0
10	915.0	400.0	311.0	6963.0
11	789.0	2641.0	675.0	4484.0
12	784.0	6243.0	640.0	922.0
13	1454.5	4231.5	1990.5	912.5
14	2488.25	1569.25	2653.25	1878.25

PFM

	A	C	G	T
01	0.292	0.288	0.191	0.229
02	0.563	0.021	0.389	0.027
03	0.0	0.71	0.0	0.289
04	0.0	0.0	1.0	0.0
05	0.0	0.0	1.0	0.0
06	1.0	0.0	0.0	0.0
07	1.0	0.0	0.0	0.0
08	0.674	0.208	0.016	0.102
09	0.279	0.119	0.205	0.397
10	0.107	0.047	0.036	0.811
11	0.092	0.307	0.079	0.522
12	0.091	0.727	0.075	0.107
13	0.169	0.493	0.232	0.106
14	0.29	0.183	0.309	0.219

PWM

	A	C	G	T
01	0.154	0.143	-0.267	-0.089
02	0.811	-2.473	0.442	-2.208
03	-6.012	1.044	-6.856	0.146
04	-6.856	-6.856	1.386	-6.856
05	-6.856	-6.856	1.386	-6.856
06	1.386	-6.856	-6.856	-6.856
07	1.386	-6.856	-6.856	-6.856
08	0.99	-0.183	-2.715	-0.894
09	0.108	-0.742	-0.196	0.462
10	-0.852	-1.676	-1.926	1.176
11	-0.999	0.207	-1.155	0.736
12	-1.006	1.067	-1.208	-0.844
13	-0.389	0.678	-0.076	-0.854
14	0.147	-0.313	0.211	-0.134

Standard thresholds

P-value	Threshold
0.001	2.68581
0.0005	4.53451
0.0001	7.29736