| Motif | NFAC1.H12CORE.2.SM.B |
| Gene (human) | NFATC1 (GeneCards) |
| Gene synonyms (human) | NFAT2, NFATC |
| Gene (mouse) | Nfatc1 |
| Gene synonyms (mouse) | Nfat2, Nfatc |
| LOGO |  |
| LOGO (reverse complement) |  |
| Motif subtype | 2 |
| Quality | B |
| Motif | NFAC1.H12CORE.2.SM.B |
| Gene (human) | NFATC1 (GeneCards) |
| Gene synonyms (human) | NFAT2, NFATC |
| Gene (mouse) | Nfatc1 |
| Gene synonyms (mouse) | Nfat2, Nfatc |
| LOGO | |
| LOGO (reverse complement) | |
| Motif subtype | 2 |
| Quality | B |
| Motif length | 20 |
| Consensus | dWWhYbnbhACGGAAAMWdn |
| GC content | 38.31% |
| Information content (bits; total / per base) | 16.419 / 0.821 |
| Data sources | HT-SELEX + Methyl-HT-SELEX |
| Aligned words | 9292 |
| ChIP-Seq benchmarking | Num. of experiments (peaksets) | auROC, median | auROC, best | auPRC, median | auPRC, best | pseudo-auROC, median | pseudo-auROC, best | pseudo-log-auROC, median | pseudo-log-auROC, best | Centrality, median | Centrality, best |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Human | 3 (16) | 0.601 | 0.733 | 0.456 | 0.605 | 0.588 | 0.726 | 1.515 | 2.198 | 16.234 | 39.444 |
| Mouse | 3 (18) | 0.713 | 0.812 | 0.582 | 0.674 | 0.678 | 0.778 | 1.963 | 2.378 | 110.838 | 189.229 |
| HT-SELEX benchmarking | auROC10 | auPRC10 | auROC25 | auPRC25 | auROC50 | auPRC50 | |
|---|---|---|---|---|---|---|---|
| Overall, 6 experiments | median | 0.956 | 0.938 | 0.881 | 0.863 | 0.735 | 0.749 |
| best | 1.0 | 1.0 | 0.998 | 0.997 | 0.963 | 0.962 | |
| Methyl HT-SELEX, 2 experiments | median | 0.991 | 0.988 | 0.97 | 0.963 | 0.881 | 0.885 |
| best | 1.0 | 1.0 | 0.998 | 0.997 | 0.963 | 0.962 | |
| Non-Methyl HT-SELEX, 4 experiments | median | 0.894 | 0.872 | 0.745 | 0.744 | 0.626 | 0.648 |
| best | 0.994 | 0.993 | 0.949 | 0.942 | 0.789 | 0.807 | |
| TF superclass | Immunoglobulin fold {6} (TFClass) |
| TF class | Rel homology region (RHR) factors {6.1} (TFClass) |
| TF family | NFAT-related {6.1.3} (TFClass) |
| TF subfamily | {6.1.3.0} (TFClass) |
| TFClass ID | TFClass: 6.1.3.0.1 |
| HGNC | HGNC:7775 |
| MGI | MGI:102469 |
| EntrezGene (human) | GeneID:4772 (SSTAR profile) |
| EntrezGene (mouse) | |
| UniProt ID (human) | NFAC1_HUMAN |
| UniProt ID (mouse) | NFAC1_MOUSE |
| UniProt AC (human) | O95644 (TFClass) |
| UniProt AC (mouse) | O88942 (TFClass) |
| GRECO-DB-TF | yes |
| ChIP-Seq | 3 human, 3 mouse |
| HT-SELEX | 4 |
| Methyl-HT-SELEX | 2 |
| PCM | NFAC1.H12CORE.2.SM.B.pcm |
| PWM | NFAC1.H12CORE.2.SM.B.pwm |
| PFM | NFAC1.H12CORE.2.SM.B.pfm |
| Alignment | NFAC1.H12CORE.2.SM.B.words.tsv |
| Threshold to P-value map | NFAC1.H12CORE.2.SM.B.thr |
| Motif in other formats | |
| JASPAR format | NFAC1.H12CORE.2.SM.B_jaspar_format.txt |
| MEME format | NFAC1.H12CORE.2.SM.B_meme_format.meme |
| Transfac format | NFAC1.H12CORE.2.SM.B_transfac_format.txt |
| Homer format | |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 1615.0 | 1298.0 | 1638.0 | 4741.0 |
| 02 | 1150.0 | 985.0 | 984.0 | 6173.0 |
| 03 | 1015.0 | 610.0 | 746.0 | 6921.0 |
| 04 | 764.0 | 3334.0 | 620.0 | 4574.0 |
| 05 | 656.0 | 5879.0 | 500.0 | 2257.0 |
| 06 | 1655.0 | 3692.0 | 2225.0 | 1720.0 |
| 07 | 1706.0 | 2194.0 | 2410.0 | 2982.0 |
| 08 | 1282.0 | 3357.0 | 1298.0 | 3355.0 |
| 09 | 3513.0 | 1756.0 | 793.0 | 3230.0 |
| 10 | 6997.0 | 19.0 | 2136.0 | 140.0 |
| 11 | 1.0 | 6046.0 | 0.0 | 3245.0 |
| 12 | 0.0 | 0.0 | 9292.0 | 0.0 |
| 13 | 0.0 | 0.0 | 9292.0 | 0.0 |
| 14 | 9292.0 | 0.0 | 0.0 | 0.0 |
| 15 | 9291.0 | 1.0 | 0.0 | 0.0 |
| 16 | 9111.0 | 164.0 | 1.0 | 16.0 |
| 17 | 5803.0 | 1952.0 | 924.0 | 613.0 |
| 18 | 3199.0 | 390.0 | 179.0 | 5524.0 |
| 19 | 3272.75 | 1054.75 | 1732.75 | 3231.75 |
| 20 | 2394.0 | 1946.0 | 1749.0 | 3203.0 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | 0.174 | 0.14 | 0.176 | 0.51 |
| 02 | 0.124 | 0.106 | 0.106 | 0.664 |
| 03 | 0.109 | 0.066 | 0.08 | 0.745 |
| 04 | 0.082 | 0.359 | 0.067 | 0.492 |
| 05 | 0.071 | 0.633 | 0.054 | 0.243 |
| 06 | 0.178 | 0.397 | 0.239 | 0.185 |
| 07 | 0.184 | 0.236 | 0.259 | 0.321 |
| 08 | 0.138 | 0.361 | 0.14 | 0.361 |
| 09 | 0.378 | 0.189 | 0.085 | 0.348 |
| 10 | 0.753 | 0.002 | 0.23 | 0.015 |
| 11 | 0.0 | 0.651 | 0.0 | 0.349 |
| 12 | 0.0 | 0.0 | 1.0 | 0.0 |
| 13 | 0.0 | 0.0 | 1.0 | 0.0 |
| 14 | 1.0 | 0.0 | 0.0 | 0.0 |
| 15 | 1.0 | 0.0 | 0.0 | 0.0 |
| 16 | 0.981 | 0.018 | 0.0 | 0.002 |
| 17 | 0.625 | 0.21 | 0.099 | 0.066 |
| 18 | 0.344 | 0.042 | 0.019 | 0.594 |
| 19 | 0.352 | 0.114 | 0.186 | 0.348 |
| 20 | 0.258 | 0.209 | 0.188 | 0.345 |
| A | C | G | T | |
|---|---|---|---|---|
| 01 | -0.363 | -0.581 | -0.349 | 0.713 |
| 02 | -0.702 | -0.857 | -0.858 | 0.977 |
| 03 | -0.827 | -1.334 | -1.134 | 1.091 |
| 04 | -1.11 | 0.361 | -1.318 | 0.677 |
| 05 | -1.262 | 0.928 | -1.532 | -0.029 |
| 06 | -0.339 | 0.463 | -0.043 | -0.3 |
| 07 | -0.308 | -0.057 | 0.037 | 0.25 |
| 08 | -0.594 | 0.368 | -0.581 | 0.367 |
| 09 | 0.413 | -0.28 | -1.073 | 0.329 |
| 10 | 1.102 | -4.694 | -0.084 | -2.794 |
| 11 | -6.562 | 0.956 | -6.926 | 0.334 |
| 12 | -6.926 | -6.926 | 1.386 | -6.926 |
| 13 | -6.926 | -6.926 | 1.386 | -6.926 |
| 14 | 1.386 | -6.926 | -6.926 | -6.926 |
| 15 | 1.385 | -6.562 | -6.926 | -6.926 |
| 16 | 1.366 | -2.638 | -6.562 | -4.846 |
| 17 | 0.915 | -0.174 | -0.92 | -1.33 |
| 18 | 0.32 | -1.78 | -2.552 | 0.866 |
| 19 | 0.342 | -0.788 | -0.293 | 0.33 |
| 20 | 0.03 | -0.177 | -0.283 | 0.321 |
| P-value | Threshold |
|---|---|
| 0.001 | -0.08944 |
| 0.0005 | 1.72521 |
| 0.0001 | 5.72481 |